scholarly journals Method Development by Use of Capillary Electrophoresis and Applications in Pharmaceutical, Biological and Natural Samples

10.5772/45834 ◽  
2012 ◽  
Author(s):  
Constantina P.
Keyword(s):  
Capillary Electrophoresis ◽  
Method Development

scholarly journals Method development for on-line species-specific sulfur isotopic analysis by means of capillary electrophoresis/multicollector ICP-mass spectrometry

2020 ◽  
Vol 412 (23) ◽  
pp. 5637-5646
Author(s):  
Sebastian Faßbender ◽  
Katerina Rodiouchkina ◽  
Frank Vanhaecke ◽  
Björn Meermann
Keyword(s):  
Mass Spectrometry ◽  
Capillary Electrophoresis ◽  
Method Development ◽  
Isotopic Analysis ◽  
On Line ◽  
Species Specific ◽  
Icp Mass Spectrometry

Enantioseparation of citalopram enantiomers by capillary electrophoresis: Method development through experimental design and computational modeling

Chirality ◽  
2020 ◽  
Vol 32 (8) ◽  
pp. 1119-1128
Author(s):  
Monica Budău ◽  
Gabriel Hancu ◽  
Daniela Lucia Muntean ◽  
Lajos Attila Papp ◽  
Anca Gabriela Cârje ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Experimental Design ◽  
Computational Modeling ◽  
Method Development ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method

Fast analysis of glibenclamide and its impurities: quality by design framework in capillary electrophoresis method development

2015 ◽  
Vol 407 (25) ◽  
pp. 7637-7646 ◽  
Author(s):  
Sandra Furlanetto ◽  
Serena Orlandini ◽  
Benedetta Pasquini ◽  
Claudia Caprini ◽  
Paola Mura ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Method Development ◽  
Quality By Design ◽  
Design Framework ◽  
Fast Analysis ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method

Use of capillary electrophoresis as a method development tool for classical gel electrophoresis

The Analyst ◽  
1998 ◽  
Vol 123 (7) ◽  
pp. 1477-1480 ◽  
Author(s):  
Richard M. C. Sutton
Keyword(s):  
Capillary Electrophoresis ◽  
Gel Electrophoresis ◽  
Method Development ◽  
Development Tool

Systematic approach to cost- and time-effective method development with a starter kit for chiral separations by capillary electrophoresis

1997 ◽  
Vol 782 (2) ◽  
pp. 257-269 ◽  
Author(s):  
Natascha Roos ◽  
Katalin Ganzler ◽  
Julianna Szemán ◽  
Salvatore Fanali
Keyword(s):  
Capillary Electrophoresis ◽  
Method Development ◽  
Systematic Approach ◽  
Chiral Separations

scholarly journals Study of interaction between polyphenolic compounds and protein using computational and capillary electrophoresis techniques

2013 ◽  
Author(s):  
◽  
Myalowenkosi Innocent Sabela
Keyword(s):  
Capillary Electrophoresis ◽  
Molecular Docking ◽  
Protein Interactions ◽  
Method Development ◽  
Docking Studies ◽  
Chiral Selector ◽  
Chiral Compounds ◽  
Multiple Binding Sites ◽  
Important Regulator ◽  
Inorganic Molecules

The present work involves the interaction studies of chiral compounds with the Human Serum Albumin (HSA) protein using computational and experimental methods. The HSA protein has multiple binding sites that forms the basis for its exceptional ability to interact with many organic and inorganic molecules, which makes this protein an important regulator of intercellular fluxes and the pharmacokinetic behaviour of many drugs. This study was undertaken to evaluate the related pharmacokinetic and enantioselective binding parameters of the racemic catechin enantiomers with the HSA. Accordingly, this work involved a method development for the chiral separation of a racemic compound, by capillary electrophoresis-electrokinetic chromatography (CE-EKC) with a highly sulphated beta-cyclodextrin (HS--CD) as a chiral selector. The experimental work was supported by two molecular docking studies. The first included the mimicking of the host-guest interactions between a chiral selector and an enantiomeric compound. The second study included the estimation of the pseudo enantioselective (ES) binding of catechin to HSA. Overall, it was found that CE-EKC is the preferred method for the(±)-catechin binding to HSA protein evaluation. Moreover, the technique used in this work is not restricted to HSA or polyphenols, but can also be applied to other proteins and ligands that possess chirality. Furthermore, the molecular docking approaches also proved to be very useful for the evaluation of chiral recognition systems and for elucidation of the ligand-protein interactions.

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