scholarly journals The Mechanisms of Epigenetic Modifications During DNA Replication

10.5772/51592 ◽  
2013 ◽  
Author(s):  
Takeo Kubota ◽  
Kunio Miyake ◽  
Takae Hirasaw
Keyword(s):  
Dna Replication ◽  
Epigenetic Modifications

scholarly journals Replication Stress and Consequential Instability of the Genome and Epigenome

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3870 ◽  
Author(s):  
Pawlos S. Tsegay ◽  
Yanhao Lai ◽  
Yuan Liu
Keyword(s):  
Dna Damage ◽  
Dna Replication ◽  
Oxidative Dna Damage ◽  
Replication Stress ◽  
Cellular Responses ◽  
Epigenetic Modifications ◽  
Daughter Cells ◽  
Dna Replication Stress ◽  
Dna Secondary Structures ◽  
The One

Cells must faithfully duplicate their DNA in the genome to pass their genetic information to the daughter cells. To maintain genomic stability and integrity, double-strand DNA has to be replicated in a strictly regulated manner, ensuring the accuracy of its copy number, integrity and epigenetic modifications. However, DNA is constantly under the attack of DNA damage, among which oxidative DNA damage is the one that most frequently occurs, and can alter the accuracy of DNA replication, integrity and epigenetic features, resulting in DNA replication stress and subsequent genome and epigenome instability. In this review, we summarize DNA damage-induced replication stress, the formation of DNA secondary structures, peculiar epigenetic modifications and cellular responses to the stress and their impact on the instability of the genome and epigenome mainly in eukaryotic cells.

Replication of Bacteriophage 186 DNA

1972 ◽  
Vol 30 ◽  
pp. 194-195
Author(s):  
Dhruba K. Chattoraj ◽  
Ross B. Inman
Keyword(s):  
Electron Microscopy ◽  
Dna Replication ◽  
Frame Of Reference ◽  
Dna Molecules ◽  
E Coli ◽  
Phage Dna ◽  
Partial Denaturation

Electron microscopy of replicating intermediates has been quite useful in understanding the mechanism of DNA replication in DNA molecules of bacteriophage, mitochondria and plasmids. The use of partial denaturation mapping has made the tool more powerful by providing a frame of reference by which the position of the replicating forks in bacteriophage DNA can be determined on the circular replicating molecules. This provided an easy means to find the origin and direction of replication in λ and P2 phage DNA molecules. DNA of temperate E. coli phage 186 was found to have an unique denaturation map and encouraged us to look into its mode of replication.

Molecular Themes in DNA Replication

2009 ◽  
Keyword(s):  
Dna Replication

The infection and viral DNA replication ofBocavirusminute virus of canine in permissive cells and non-permissive cells

2010 ◽  
Vol 34 (8) ◽  
pp. S60-S60
Author(s):  
Yuning Sun ◽  
Fang Li ◽  
Jianming Qiu ◽  
Xiaohong Lu
Keyword(s):  
Dna Replication ◽  
Viral Dna ◽  
Viral Dna Replication

DNA replication and the development of preprophase bands in soybean protoplast cultures

1991 ◽  
Vol 82 (2) ◽  
pp. 150-156 ◽  
Author(s):  
Hong Wang ◽  
Adrian J. Cutler ◽  
Larry C. Fowke
Keyword(s):  
Dna Replication ◽  
Preprophase Bands

The Control of Mammalian DNA Replication A Brief History of Space and Timing

Cell ◽  
2001 ◽  
Vol 104 (5) ◽  
pp. 643-646 ◽  
Author(s):  
D Cimbora
Keyword(s):  
Dna Replication ◽  
History Of

Non-canonical functions of Cyclin E1 for control of hepatic DNA replication and liver regeneration in mice

2012 ◽  
Vol 50 (01) ◽  
Author(s):  
W Hu ◽  
YA Nevzorova ◽  
U Haas ◽  
P Sicinski ◽  
M Barbacid ◽  
...  
Keyword(s):  
Dna Replication ◽  
Liver Regeneration ◽  
Cyclin E1

DNA Replication Licensing Factor MCM6

2020 ◽  
Author(s):  
Keyword(s):  
Dna Replication ◽  
Licensing Factor
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