scholarly journals Strain-Specific Allele Loss: An Important Clue to Tumor Suppressors Involved in Tumor Susceptibility

10.5772/55159 ◽  
2013 ◽  
Author(s):  
Nobuko Mori ◽  
Yoshiki Ok
Keyword(s):  
Tumor Suppressors ◽  
Tumor Susceptibility ◽  
Allele Loss ◽  
Important Clue ◽  
Specific Allele

scholarly journals TSG101 Associates with PARP1 and is Essential for PARylation and DNA Damage-induced NF-κB Activation

2021 ◽  
Author(s):  
Ahmet Bugra Tufan ◽  
Katina Lazarow ◽  
Marina Kolesnichenko ◽  
Anje Sporbert ◽  
Jens Peter von Kries ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Dna Damage ◽  
Tumor Suppressors ◽  
Breast Cancer Cells ◽  
Synthetic Lethality ◽  
Parp Inhibition ◽  
Endosomal Sorting ◽  
Tumor Susceptibility ◽  
Genome Wide ◽  
A Genome

SUMMARYIn a genome-wide screening for components of the dsDNA-break-induced IKK-NF-κB pathway we identified scores of regulators, including tumor susceptibility protein TSG101. TSG101 is essential for DNA damage-induced formation of cellular poly(ADP-ribose) (PAR). TSG101 directly binds to PARP1 and is required for PARP1 activation. This function of TSG101 is independent of its role in the ESCRT-I endosomal sorting complex. In the absence of TSG101, the PAR-dependent formation of a nuclear PARP1-IKKγ signalosome, which triggers IKK activation, is impaired. According to its requirement for PARP1 and NF-κB activation, TSG101 deficient cells are defective in DNA repair and apoptosis protection. Loss of TSG101 results in PARP1 trapping at damage sites and mimics the effect of pharmacological PARP-inhibition. We also show that loss of TSG101 in connection with inactivated tumor suppressors BRCA1/2 in breast cancer cells is lethal. Our results imply TSG101 as a therapeutic target to achieve synthetic lethality in cancer treatment.

Synergistic antitumor effect of ING4/PTEN double tumor suppressors mediated by adenovirus modified with arginine-glycine-aspartate on glioma

2020 ◽  
Vol 64 (2) ◽  
Author(s):  
Yaodong Zhao ◽  
Jiarong Wang ◽  
Jicheng Yang ◽  
Jingcheng Miao
Keyword(s):  
Tumor Suppressors ◽  
Antitumor Effect ◽  
Synergistic Antitumor Effect

Tumor susceptibility gene 101 protein

2007 ◽  
Author(s):  
Thomas Slagsvold
Keyword(s):  
Susceptibility Gene ◽  
Tumor Susceptibility ◽  
Tumor Susceptibility Gene

The Prognostic and Predictive Value of microRNAs in Patients with H. pylori-positive Gastric Cancer

2019 ◽  
Vol 24 (39) ◽  
pp. 4639-4645 ◽  
Author(s):  
Seyed Mostafa Parizadeh ◽  
Reza Jafarzadeh-Esfehani ◽  
Amir Avan ◽  
Maryam Ghandehari ◽  
Fatemeh Goldani ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Tumor Suppressors ◽  
Ectopic Expression ◽  
Noncoding Rnas ◽  
World Population ◽  
Normal Flora ◽  
Small Noncoding Rnas ◽  
Control Gene Expression ◽  
The World ◽  
H Pylori

Gastric cancer (GC) has a high mortality rate with a poor 5-year survival. Helicobacter pylori (H. pylori) is present as part of the normal flora of stomach. It is found in the gastric mucosa of more than half of the world population. This bacterium is involved in developing H. pylori-induced GC due to the regulation of different micro ribonucleic acid (miRNA or miR). miRNAs are small noncoding RNAs and are recognized as prognostic biomarkers for GC that may control gene expression. miRNAs may function as tumor suppressors, or oncogenes. In this review, we evaluated studies that investigated the ectopic expression of miRNAs in the prognosis of H. pylori positive and negative GC.

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