scholarly journals Vascular Tissue Development and Regeneration in the Model Plant Arabidopsis

2017 ◽  
Author(s):  
Ewa Mazur ◽  
Jiří Friml
Keyword(s):  
Vascular Tissue ◽  
Tissue Development ◽  
Model Plant

Production and transplantation of bioengineered lung into a large-animal model

2018 ◽  
Vol 10 (452) ◽  
pp. eaao3926 ◽  
Author(s):  
Joan E. Nichols ◽  
Saverio La Francesca ◽  
Jean A. Niles ◽  
Stephanie P. Vega ◽  
Lissenya B. Argueta ◽  
...  
Keyword(s):  
Vascular Tissue ◽  
Fundamental Problem ◽  
Transplant Rejection ◽  
Systemic Circulation ◽  
Large Animal Model ◽  
Large Animal ◽  
Bioreactor Culture ◽  
Tissue Development ◽  
Alveolar Tissue ◽  
Vessel Development

The inability to produce perfusable microvasculature networks capable of supporting tissue survival and of withstanding physiological pressures without leakage is a fundamental problem facing the field of tissue engineering. Microvasculature is critically important for production of bioengineered lung (BEL), which requires systemic circulation to support tissue survival and coordination of circulatory and respiratory systems to ensure proper gas exchange. To advance our understanding of vascularization after bioengineered organ transplantation, we produced and transplanted BEL without creation of a pulmonary artery anastomosis in a porcine model. A single pneumonectomy, performed 1 month before BEL implantation, provided the source of autologous cells used to bioengineer the organ on an acellular lung scaffold. During 30 days of bioreactor culture, we facilitated systemic vessel development using growth factor–loaded microparticles. We evaluated recipient survival, autograft (BEL) vascular and parenchymal tissue development, graft rejection, and microbiome reestablishment in autografted animals 10 hours, 2 weeks, 1 month, and 2 months after transplant. BEL became well vascularized as early as 2 weeks after transplant, and formation of alveolar tissue was observed in all animals (n= 4). There was no indication of transplant rejection. BEL continued to develop after transplant and did not require addition of exogenous growth factors to drive cell proliferation or lung and vascular tissue development. The sterile BEL was seeded and colonized by the bacterial community of the native lung.

scholarly journals The Histidine Kinases CYTOKININ-INDEPENDENT1 and ARABIDOPSIS HISTIDINE KINASE2 and 3 Regulate Vascular Tissue Development in Arabidopsis Shoots

2009 ◽  
Vol 21 (7) ◽  
pp. 2008-2021 ◽  
Author(s):  
Jan Hejátko ◽  
Hojin Ryu ◽  
Gyung-Tae Kim ◽  
Romana Dobešová ◽  
Sunhwa Choi ◽  
...  
Keyword(s):  
Vascular Tissue ◽  
Tissue Development ◽  
Histidine Kinases

scholarly journals A CLE–WOX signalling module regulates root meristem maintenance and vascular tissue development in rice

2013 ◽  
Vol 64 (17) ◽  
pp. 5359-5369 ◽  
Author(s):  
Huangwei Chu ◽  
Wanqi Liang ◽  
Juan Li ◽  
Fan Hong ◽  
Yunfei Wu ◽  
...  
Keyword(s):  
Vascular Tissue ◽  
Root Meristem ◽  
Tissue Development ◽  
Meristem Maintenance
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