scholarly journals SOX Genes and Cancer

2018 ◽  
Author(s):  
Li Cui ◽  
Xinyuan Zhao ◽  
Shen Hu
Keyword(s):  
Sox Genes

Molecular evolution of Sry and Sox genes

2000 ◽  
Vol 28 (5) ◽  
pp. A186-A186
Author(s):  
K. Nagai
Keyword(s):  
Molecular Evolution ◽  
Sox Genes

scholarly journals Differential Expression of Members of SOX Family of Transcription Factors in Failing Human Hearts

2020 ◽  
Author(s):  
Chia-Feng Liu ◽  
Ying Ng ◽  
Varun Thachil ◽  
Michael Morley ◽  
Christine S Moravec ◽  
...  
Keyword(s):  
Transcription Factors ◽  
Differential Expression ◽  
Cardiac Fibrosis ◽  
Meta Analysis ◽  
High Mobility ◽  
Human Myocardium ◽  
Cardiac Tissues ◽  
Protein Levels ◽  
Sox Genes ◽  
Rna Levels

Abstract Background: The Sry-related high-mobility-group box (SOX) gene family, with 20 known transcription factors in humans, plays essential roles during development and in many disease processes. Several SOX proteins, e.g., SOX4, SOX11, and SOX9, are required for normal heart morphogenesis. SOX9 was shown to contribute to cardiac fibrosis in animal models. However, differential expression of other SOX transcription factors and their functional roles in the failing human myocardium have not been explored.Methods and Findings: All 20 SOX genes from RNA-seq data were extracted, and their RNA levels were compared to the NF, DCM, and hypertrophic cardiomyopathy (HCM) groups. The protein levels of the differential expressed SOX genes were confirmed by Western blot. Four SOX genes whose RNA levels were significantly upregulated in DCM or HCM compared to NF. However, only SOX4 and SOX8 proteins were markedly increased in the heart failure groups. Gene co-expression network analysis identified genes associated and respond similarly to perturbations with SOX4 in cardiac tissues. Using a meta-analysis combining epigenetics and genome-wide association data, we reported several genomic variants associated with HF phenotype linked to SOX4 or SOX8.Conclusions: Elevation of SOX8 and SOX4 are observed in the failing human myocardium. The molecular mechanism associated with them in HF warrants further investigation.

scholarly journals Isolation and sequencing of seven Sox genes from the lacertid lizard Eremias breuchleyi

2006 ◽  
Vol 29 (3) ◽  
pp. 576-579 ◽  
Author(s):  
Li Jie ◽  
Ping-Ping Zheng ◽  
Jiao-Lian Song ◽  
Jin-Long Rui ◽  
Liu-Wang Nie
Keyword(s):  
Lacertid Lizard ◽  
Sox Genes

SOX genes and neural progenitor identity

2005 ◽  
Vol 15 (1) ◽  
pp. 7-13 ◽  
Author(s):  
Larysa Pevny ◽  
Marysia Placzek
Keyword(s):  
Neural Progenitor ◽  
Sox Genes

scholarly journals Multiple Sox genes are expressed in stem cells or in differentiating neuro-sensory cells in the hydrozoan Clytia hemisphaerica

EvoDevo ◽  
2011 ◽  
Vol 2 (1) ◽  
pp. 12 ◽  
Author(s):  
Muriel Jager ◽  
Eric Quéinnec ◽  
Hervé Le Guyader ◽  
Michaël Manuel
Keyword(s):  
Stem Cells ◽  
Sensory Cells ◽  
Sox Genes

scholarly journals Differential expression and prognostic significance of SOX genes in pediatric medulloblastoma and ependymoma identified by microarray analysis

2008 ◽  
Vol 10 (5) ◽  
pp. 648-660 ◽  
Author(s):  
Judith M. de Bont ◽  
Johan M. Kros ◽  
Monique M.C.J. Passier ◽  
Roel E. Reddingius ◽  
Peter A.E. Sillevis Smitt ◽  
...  
Keyword(s):  
Differential Expression ◽  
Microarray Analysis ◽  
Prognostic Significance ◽  
Pediatric Medulloblastoma ◽  
Sox Genes

scholarly journals Embryonic expression patterns and phylogenetic analysis of panarthropod sox genes: insight into nervous system development, segmentation and gonadogenesis

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Ralf Janssen ◽  
Emil Andersson ◽  
Ellinor Betnér ◽  
Sifra Bijl ◽  
Will Fowler ◽  
...  
Keyword(s):  
Phylogenetic Analysis ◽  
Nervous System ◽  
System Development ◽  
Expression Patterns ◽  
Nervous System Development ◽  
Insight Into ◽  
Sox Genes

scholarly journals Genome-wide analysis of Sox genes in Drosophila melanogaster

2001 ◽  
Vol 109 (2) ◽  
pp. 371-375 ◽  
Author(s):  
Frédéric Crémazy ◽  
Philippe Berta ◽  
Franck Girard
Keyword(s):  
Drosophila Melanogaster ◽  
Genome Wide Analysis ◽  
Genome Wide ◽  
Sox Genes

scholarly journals Isolation and sequencing of the HMG domain of ten Sox genes from Odorrana schmackeri (Amphibia: Anura)

2009 ◽  
Vol 26 (1) ◽  
pp. 109-117
Author(s):  
Ning Wang ◽  
Jing J. Wang ◽  
Rui Jia ◽  
Jin W. Xu ◽  
Liu W. Nie
Keyword(s):  
Sox Genes

scholarly journals The evolution of Sox gene repertoires and regulation of segmentation in arachnids

2020 ◽  
Author(s):  
Luis Baudouin-Gonzalez ◽  
Anna Schoenauer ◽  
Amber Harper ◽  
Grace Blakeley ◽  
Michael Seiter ◽  
...  
Keyword(s):  
Regulatory Networks ◽  
Close Relative ◽  
System Specification ◽  
Germline Development ◽  
Simultaneous Formation ◽  
Parasteatoda Tepidariorum ◽  
Stem Cell Maintenance ◽  
Arthropod Species ◽  
Anterior Segments ◽  
Sox Genes

AbstractThe Sox family of transcription factors regulate many different processes during metazoan development, including stem cell maintenance, nervous system specification and germline development. In addition, it has recently become apparent that SoxB genes are involved in embryonic segmentation in several arthropod species. Segmentation in arthropods occurs in two main ways: long germ animals form all segments at once, best exemplified in the well-studied Drosophila melanogaster system, and short germ animals form anterior segments simultaneously, with posterior segments added sequentially from a segment addition zone. In both D. melanogaster and the short germ beetle Tribolium castaneum, the SoxB gene Dichaete is required for correct segmentation and, more recently, we showed that a close relative of Dichaete, Sox21b-1, is required for the simultaneous formation of prosomal segments and sequential addition of opisthosomal segments in the spider Parasteatoda tepidariorum. Here we further analysed the function and expression of Sox21b-1 in P. tepidariorum. We found that while this gene regulates the generation of both prosomal and opisthosomal segments, it plays different roles in the formation of these tagma reflecting their contrasting modes of segmentation and deployment of gene regulatory networks with different architectures. To further investigate the evolution of Sox genes and their roles we characterised the repertoire of the gene family across several arachnid species with and without an ancestral whole genome duplication, and compared Sox expression between P. tepidariorum and the harvestman Phalangium opilio. The results suggest that Sox21b-1 was likely involved in segmentation ancestrally in arachnids, but that other Sox genes could also regulate this process in these animals. We also found that most Sox families have been retained as duplicates or ohnologs after WGD and evidence for potential subfunctionalisation and/or neofunctionalization events.

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