scholarly journals Human Placenta-Derived Mesenchymal Stromal Cells: A Review from Basic Research to Clinical Applications

2019 ◽  
Author(s):  
Paz de la Torre ◽  
María Jesús Pérez-Lorenzo ◽  
Ana I. Flores
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Human Placenta ◽  
Stromal Cells ◽  
Basic Research ◽  
Clinical Applications

Production via good manufacturing practice of exofucosylated human mesenchymal stromal cells for clinical applications

Cytotherapy ◽  
2018 ◽  
Vol 20 (9) ◽  
pp. 1110-1123 ◽  
Author(s):  
MARÍA DOLORES LÓPEZ-LUCAS ◽  
GISELA PACHÓN-PEÑA ◽  
ANA MARÍA GARCÍA-HERNÁNDEZ ◽  
ANTONIO PARRADO ◽  
DARÍO SÁNCHEZ-SALINAS ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Good Manufacturing Practice ◽  
Clinical Applications ◽  
Human Mesenchymal Stromal Cells

Human placenta derived mesenchymal stromal cells alleviate GVHD by promoting the generation of GSH and GST in PD-1+T cells

2020 ◽  
Vol 352 ◽  
pp. 104083
Author(s):  
Wang Zhuoya ◽  
Zhao Nannan ◽  
Zhang Aiping ◽  
Wang Guoyan ◽  
Dong Menghua ◽  
...  
Keyword(s):  
T Cells ◽  
Mesenchymal Stromal Cells ◽  
Human Placenta ◽  
Stromal Cells

In Vitro Characterization of Multipotent Mesenchymal Stromal Cells Isolated from Palatal Subepithelial Tissue Grafts

2013 ◽  
Vol 19 (2) ◽  
pp. 370-380 ◽  
Author(s):  
Alexandra Roman ◽  
Andrada Şoancă ◽  
Adrian Florea ◽  
Emőke Páll
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Embryoid Body ◽  
Basic Research ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Positive Staining ◽  
Basic Characteristics ◽  
Tissue Grafts

AbstractThe aim of this study was to analyze whether the mesenchymal stromal cells (MSCs) isolated from palatal tissue grafts harvested in order to cover gingival recessions have the basic characteristics of stem cells. The palatal tissue cells were processed using a special culture medium that stimulated the development of only undifferentiated cellular lines. Cells at passage 4 were evaluated by flow cytometry to examine the expression of specific surface markers and were tested for multilineage differentiation capacity. These cells collected at passage 4 were also investigated for the capacity to cluster into embryoid body aggregates. Palatal MSCs displayed positive staining for the mesenchymal markers CD29, CD73, CD105, CD 49e, and CD44, but did not express hematopoietic markers CD34/45. The palatal MSCs successfully differentiated into osteogenic, adipogenic, and chondrogenic lineages. When seeded in special conditions, palatal MSCs propagated into unattached spheres resembling embryoid body aggregates consisting both of differentiated and undifferentiated cells as revealed at the ultrastructural evaluation. It is concluded that the isolated palatal MSCs fulfilled the basic criteria defining the stem cells. This new source of stem cells characterized here for the first time opens new perspectives on possible applications in basic research and in regenerative medicine.

A critical appraisal of humanized alternatives to fetal bovine serum for clinical applications of umbilical cord derived mesenchymal stromal cells

2021 ◽  
Author(s):  
Suneel Rallapalli ◽  
Soma Guhathakurta ◽  
Dillip Kumar Bishi ◽  
Rajasekaran Subbarayan ◽  
Santosh Mathapati ◽  
...  
Keyword(s):  
Umbilical Cord ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Bovine Serum ◽  
Critical Appraisal ◽  
Fetal Bovine Serum ◽  
Clinical Applications ◽  
Fetal Bovine
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