scholarly journals ABO Blood Group Antigens as a Model of Studying Protein-Protein Interactions

Blood Groups ◽  
2019 ◽  
Author(s):  
Frida N. Gylmiyarova ◽  
Elena Ryskina ◽  
Nataliya Kolotyeva ◽  
Valeriia Kuzmicheva ◽  
Oksana Gusyakova
Keyword(s):  
Blood Group ◽  
Protein Interactions ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Protein Protein Interactions

scholarly journals NMR Experiments Shed New Light on Glycan Recognition by Human and Murine Norovirus Capsid Proteins

Viruses ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 416
Author(s):  
Robert Creutznacher ◽  
Thorben Maass ◽  
Patrick Ogrissek ◽  
Georg Wallmann ◽  
Clara Feldmann ◽  
...  
Keyword(s):  
Blood Group ◽  
Protein Interactions ◽  
Capsid Proteins ◽  
Blood Group Antigens ◽  
Biological Processes ◽  
Murine Norovirus ◽  
Human Norovirus ◽  
Head Groups ◽  
Significant Difference

Glycan–protein interactions are highly specific yet transient, rendering glycans ideal recognition signals in a variety of biological processes. In human norovirus (HuNoV) infection, histo-blood group antigens (HBGAs) play an essential but poorly understood role. For murine norovirus infection (MNV), sialylated glycolipids or glycoproteins appear to be important. It has also been suggested that HuNoV capsid proteins bind to sialylated ganglioside head groups. Here, we study the binding of HBGAs and sialoglycans to HuNoV and MNV capsid proteins using NMR experiments. Surprisingly, the experiments show that none of the norovirus P-domains bind to sialoglycans. Notably, MNV P-domains do not bind to any of the glycans studied, and MNV-1 infection of cells deficient in surface sialoglycans shows no significant difference compared to cells expressing respective glycans. These findings redefine glycan recognition by noroviruses, challenging present models of infection.

scholarly journals ABO Blood Group Antigens on HeLa-S3 Cell Shown by Elution Method

1971 ◽  
Vol 104 (1) ◽  
pp. 93-98 ◽  
Author(s):  
TAKUSABURO EBINA ◽  
MORIO HOMMA ◽  
NAKAO ISHIDA ◽  
TOSHIYUKI KUDO
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Hela S3 ◽  
Elution Method

Study of Tolerance to the ABO Blood Group Antigens

Vox Sanguinis ◽  
1966 ◽  
Vol 11 (1) ◽  
pp. 33-37 ◽  
Author(s):  
K. Mayeda
Keyword(s):  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group Antigens

scholarly journals ABO blood group antigens of human spermatozoa.

1985 ◽  
Vol 147 (3) ◽  
pp. 267-272 ◽  
Author(s):  
KATSUHIRO TAKEDA ◽  
KOUICHI KIRAIWA
Keyword(s):  
Blood Group ◽  
Human Spermatozoa ◽  
Abo Blood Group ◽  
Blood Group Antigens

ABO Blood Group Antigens on Human Plasma von Willebrand Factor After ABO-Mismatched Bone Marrow Transplantation

Blood ◽  
1999 ◽  
Vol 94 (8) ◽  
pp. 2895-2900 ◽  
Author(s):  
Taei Matsui ◽  
Taketo Shimoyama ◽  
Masanori Matsumoto ◽  
Yoshihiro Fujimura ◽  
Yoshinobu Takemoto ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Endothelial Cells ◽  
Stem Cell ◽  
Bone Marrow Transplantation ◽  
Stem Cell Transplantation ◽  
Blood Group ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Von Willebrand ◽  
Willebrand Factor

von Willebrand factor (vWF) is synthesized exclusively by endothelial cells and megakaryocytes, and stored in the intracellular granules or constitutively secreted into plasma. ABO blood group antigens are covalently associated with asparagine-linked sugar chains of plasma vWF. The effect of ABO-mismatched bone marrow transplantation (BMT) or blood stem cell transplantation (BSCT) on the expression of ABO blood group antigens on the vWF was examined to obtain information on the origin of these antigens. In ABO-mismatched (HLA-matched) groups, 8 cases of BMT and 4 cases of BSCT were examined. In all cases, the ABO blood groups on red blood cells were gradually converted to the donor’s type within 80 to 90 days after the transplantation. The blood group antigens on the vWF were consistent with the recipient’s blood group for the period monitored by enzyme-linked immunosorbent assay (ELISA). When vWF was isolated from normal platelets and examined for the blood group antigens using ELISA or immunoblotting, it showed few antigens. However, vWF extracted from veins expressed blood group antigens. These findings indicate that platelet (megakaryocyte)-derived vWF does not contain blood group antigens and that these antigens may be specifically associated with vWF synthesized in endothelial cells and secreted into plasma. Furthermore, it is possible that the persistence of the recipient’s blood group antigens on plasma glycoproteins such as vWF, independent of the donor-derived erythrocytes, after ABO-mismatched stem cell transplantation, may influence the immunological system in the production of anti-blood group antibodies resulting in the establishment of immunological tolerance in the recipient plasma.

scholarly journals Non-secretion of ABO blood group antigens as a host susceptibility factor in the spondyloarthropathies.

BMJ ◽  
1987 ◽  
Vol 294 (6566) ◽  
pp. 208-210 ◽  
Author(s):  
R Shinebaum ◽  
C C Blackwell ◽  
P J Forster ◽  
N P Hurst ◽  
D M Weir ◽  
...  
Keyword(s):  
Blood Group ◽  
Host Susceptibility ◽  
Abo Blood Group ◽  
Blood Group Antigens ◽  
Susceptibility Factor
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