scholarly journals The Potential Contribution of Nanoparticles in the Treatment of Inflammatory Diseases

2020 ◽  
Author(s):  
Mona A. Elsayed ◽  
Ayman Norredin
Keyword(s):  
Inflammatory Diseases ◽  
Potential Contribution

scholarly journals Transcriptional Profiling and Functional Analysis of N1/N2 Neutrophils Reveal an Immunomodulatory Effect of S100A9-Blockade on the Pro-Inflammatory N1 Subpopulation

2021 ◽  
Vol 12 ◽  
Author(s):  
Andreea C. Mihaila ◽  
Letitia Ciortan ◽  
Razvan D. Macarie ◽  
Mihaela Vadana ◽  
Sergiu Cecoltan ◽  
...  
Keyword(s):  
Inflammatory Diseases ◽  
Transcriptional Profiling ◽  
Innate Immune ◽  
Potential Contribution ◽  
Functional Differences ◽  
Elevated Expression ◽  
Pharmacological Blockade ◽  
Novel Target ◽  
Increased Activity ◽  
Homogenous Population

Neutrophils have been classically viewed as a homogenous population. Recently, neutrophils were phenotypically classified into pro-inflammatory N1 and anti-inflammatory N2 sub-populations, but the functional differences between the two subtypes are not completely understood. We aimed to investigate the phenotypic and functional differences between N1 and N2 neutrophils, and to identify the potential contribution of the S100A9 alarmin in neutrophil polarization. We describe distinct transcriptomic profiles and functional differences between N1 and N2 neutrophils. Compared to N2, the N1 neutrophils exhibited: i) higher levels of ROS and oxidative burst, ii) increased activity of MPO and MMP-9, and iii) enhanced chemotactic response. N1 neutrophils were also characterized by elevated expression of NADPH oxidase subunits, as well as activation of the signaling molecules ERK and the p65 subunit of NF-kB. Moreover, we found that the S100A9 alarmin promotes the chemotactic and enzymatic activity of N1 neutrophils. S100A9 inhibition with a specific small-molecule blocker, reduced CCL2, CCL3 and CCL5 chemokine expression and decreased MPO and MMP-9 activity, by interfering with the NF-kB signaling pathway. Together, these findings reveal that N1 neutrophils are pro-inflammatory effectors of the innate immune response. Pharmacological blockade of S100A9 dampens the function of the pro-inflammatory N1 phenotype, promoting the alarmin as a novel target for therapeutic intervention in inflammatory diseases.

scholarly journals The Potential Interplay of Adipokines with Toll-Like Receptors in the Development of Hepatocellular Carcinoma

2011 ◽  
Vol 2011 ◽  
pp. 1-10 ◽  
Author(s):  
Shen-Nien Wang ◽  
Sen-Te Wang ◽  
King Teh Lee
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chronic Inflammation ◽  
Metabolic Diseases ◽  
Viral Infections ◽  
Inflammatory Diseases ◽  
Epidemiological Data ◽  
Potential Interaction ◽  
Potential Contribution ◽  
Toll Like Receptors

Toll-like receptors (TLRs) are not only crucial to the initiation of the immune system, but also play a key role in several human inflammatory diseases. Hepatocellular carcinoma (HCC) is among those human cancers, which arise from sites of chronic inflammation. Therefore, a number of studies have explored the potential contribution of TLRs to HCC occurrence, which is initiated by exposure to chronic hepatic inflammation of different etiologies (including ethanol, and chronic B and C viral infections). Recent epidemiological data have shown the association of obesity and HCC development. Given the fact that adipose tissues can produce a variety of inflammation-related adipokines, obesity has been characterized as a state of chronic inflammation. Adipokines are therefore considered as important mediators linking inflammation to several metabolic diseases, including cancers. More recently, many experts have also shown the bridging role of TLRs between inflammation and metabolism. Hopefully, to retrieve the potential interaction between TLRs and adipokines in carcinogenesis of HCC will shed a new light on the therapeutic alternative for HCC. In this paper, the authors first review the respective roles of TLRs and adipokines, discuss their mutual interaction in chronic inflammation, and finally anticipate further investigations of this interaction in HCC development.

scholarly journals Purinergic Signaling in Neutrophils During Inflammatory Diseases

2020 ◽  
Author(s):  
Hui Sun ◽  
Gang Xu ◽  
Pingsong Li ◽  
Yumei Li ◽  
Bingwei Sun
Keyword(s):  
Immune System ◽  
Immune Cells ◽  
Inflammatory Disease ◽  
Inflammatory Diseases ◽  
Purinergic Signaling ◽  
Regulatory Function ◽  
Potential Contribution ◽  
Complex Events ◽  
Inflammatory Molecules

Purinergic signaling is that nucleotides (especially ATP) and adenosine are utilized as transmitter molecules, which play an important role in the immune system. In the extracellular ventricle, ATP plays a significant role of pro-inflammatory molecules mainly through activating P2 receptors, while adenosine plays the role of anti-inflammatory molecules mainly through activating P1 receptors. As we know，neutrophils are the most abundant immune cells in our circulation and have become an essential part of coordinating a series of complex events during inflammatory diseases. However, due to the destruction of inflammatory substances from neutrophils, the activation of neutrophils is fine-tuned, and purinergic signaling is associated with this process. As a matter of fact, altering the balance between P2 and P1 signals is of great importance for neutrophils to exert immune activities properly. Here, we review the role of purinergic signaling in regulatory function of neutrophils during inflammatory disease, and then discuss the potential contribution of targeted purinergic signals in the treatment of the neutrophil during inflammatory diseases.

Complications of Inflammatory Diseases of the Sinuses

1993 ◽  
Vol 26 (4) ◽  
pp. 639-655 ◽  
Author(s):  
James A. Stankiewicz ◽  
David J. Newell ◽  
Albert H. Park
Keyword(s):  
Inflammatory Diseases

Nutritional modification of inflammatory diseases

1997 ◽  
Vol 12 (3) ◽  
pp. 212-222 ◽  
Author(s):  
W.D. Schoenherr ◽  
Dennis E. Jewell
Keyword(s):  
Inflammatory Diseases

The potential contribution of psychology to nuclear war issues.

1988 ◽  
Vol 43 (4) ◽  
pp. 318-321 ◽  
Author(s):  
Michael D. Intriligator ◽  
Dagobert L. Brito
Keyword(s):  
Potential Contribution ◽  
Nuclear War

Psychology: Its potential contribution to research on food and nutrition problems

1976 ◽  
Author(s):  
Nancy Felipe Russo ◽  
James R. Richards
Keyword(s):  
Potential Contribution ◽  
Food And Nutrition

Gene expression linked to inflammatory diseases

2013 ◽  
Author(s):  
Sara Osman
Keyword(s):  
Gene Expression ◽  
Inflammatory Diseases

Alzheimerʼs disease, Parkinsonʼs disease and schizophrenia are not inflammatory diseases while inflammation is recognizable beyond organ borders

2015 ◽  
Vol 48 (06) ◽  
Author(s):  
M Filiou ◽  
A Arefin ◽  
P Moscato ◽  
M Graeber
Keyword(s):  
Inflammatory Diseases
Sign in / Sign up

Export Citation Format

Share Document