scholarly journals The Experimental Bioengineering of Complete Spinal Cord Injury in Adult Rats

2020 ◽  
Author(s):  
I.N. Bolshakov ◽  
A.V. Svetlakov ◽  
A.V. Eremeev ◽  
Yu.I. Sheina
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adult Rats ◽  
Cord Injury ◽  
Complete Spinal Cord Injury

scholarly journals Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats

eLife ◽  
2017 ◽  
Vol 6 ◽  
Author(s):  
Anitha Manohar ◽  
Guglielmo Foffani ◽  
Patrick D Ganzer ◽  
John R Bethea ◽  
Karen A Moxon
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cortical Reorganization ◽  
Sensory Cortex ◽  
Adult Rats ◽  
Weight Support ◽  
Cord Injury ◽  
Recovery Strategies ◽  
Physical Therapies ◽  
Complete Spinal Cord Injury

After paralyzing spinal cord injury the adult nervous system has little ability to ‘heal’ spinal connections, and it is assumed to be unable to develop extra-spinal recovery strategies to bypass the lesion. We challenge this assumption, showing that completely spinalized adult rats can recover unassisted hindlimb weight support and locomotion without explicit spinal transmission of motor commands through the lesion. This is achieved with combinations of pharmacological and physical therapies that maximize cortical reorganization, inducing an expansion of trunk motor cortex and forepaw sensory cortex into the deafferented hindlimb cortex, associated with sprouting of corticospinal axons. Lesioning the reorganized cortex reverses the recovery. Adult rats can thus develop a novel cortical sensorimotor circuit that bypasses the lesion, probably through biomechanical coupling, to partly recover unassisted hindlimb locomotion after complete spinal cord injury.

scholarly journals Author response: Cortex-dependent recovery of unassisted hindlimb locomotion after complete spinal cord injury in adult rats

2017 ◽  
Author(s):  
Anitha Manohar ◽  
Guglielmo Foffani ◽  
Patrick D Ganzer ◽  
John R Bethea ◽  
Karen A Moxon
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Author Response ◽  
Adult Rats ◽  
Cord Injury ◽  
Complete Spinal Cord Injury

scholarly journals Exploring daily blood pressure fluctuations and cardiovascular risk among individuals with motor complete spinal cord injury: a pilot study

2016 ◽  
Vol 40 (4) ◽  
pp. 405-414 ◽  
Author(s):  
Derry L. Dance ◽  
Amit Chopra ◽  
Kent Campbell ◽  
David S. Ditor ◽  
Magdy Hassouna ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Cardiovascular Risk ◽  
Pilot Study ◽  
Pressure Fluctuations ◽  
Cord Injury ◽  
Complete Spinal Cord Injury
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