scholarly journals Androgens and Cardiovascular Risk Factors in Polycystic Ovary Syndrome

2021 ◽  
Author(s):  
Licy L. Yanes Cardozo ◽  
Alexandra M. Huffman ◽  
Jacob E. Pruett ◽  
Damian G. Romero
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Receptor Activation ◽  
Ovary Syndrome ◽  
Androgen Synthesis

Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder in reproductive-aged women. Clinical or biochemical signs of androgen excess is a cardinal feature of the syndrome and are present in approximately 80% of women with PCOS. Increased blood pressure and insulin resistance, two major cardiovascular risk factors, are frequently present in women with PCOS. This chapter aims to highlight the fundamental role of androgens in mediating the increased blood pressure and insulin resistance in women with PCOS. This chapter is also a call for action to develop new pharmacological therapies that target the androgen synthesis and androgen receptor activation dysregulation present in women with PCOS. These novel therapies will allow to prevent or mitigate the excess androgen-mediated cardiovascular risk factors that affect women with PCOS.

scholarly journals Age and body mass related changes of cardiovascular risk factors in women with polycystic ovary syndrome

2002 ◽  
Vol 59 (6) ◽  
pp. 593-599 ◽  
Author(s):  
Djuro Macut ◽  
Dragan Micic ◽  
Biljana Parapid ◽  
Goran Cvijovic ◽  
Mirjana Sumarac-Dumanovic ◽  
...  
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Blood Pressure ◽  
Cardiovascular Risk ◽  
Glucose Metabolism ◽  
Polycystic Ovary Syndrome ◽  
Lipid Profile ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Ovary Syndrome

Polycystic ovary syndrome (PCOS) is considered a metabolic disorder closely related to obesity, insulin resistance (IR), hyperinsulinemia and unfavorable lipid profile, all increasing the risk for the occurrence of cardiovascular diseases. The aim of this study was to assess age and body mass index (BMI) related changes of cardiovascular risk factors in 90 women with PCOS. The cut-off age point was 30 years and for BMI 27.8 kg/m2. In all patients systolic and diastolic blood pressure (BP), metabolic parameters comprising values of glucose and insulin during oral glucose tolerance test (OGTT), and basal lipid values were determined. Significant increase in blood pressure (BP) indices, basal insulin values and insulin resistance (IR) assessed by HOMA model were observed with aging and the increase of BMI, while the parameters of glucose metabolism, total cholesterol and triglycerides were significantly elevated only with aging. However, the correlation between the indices of arterial blood pressure, and lipid and glucose metabolism parameters occurred only in patients over 30 years of age, pointing to the causative relation and the consequent deterioration of IR and lipid profile with aging, influencing cardiovascular function in women with PCOS.

Relative impact of insulin resistance and obesity on cardiovascular risk factors in polycystic ovary syndrome

Metabolism ◽  
2003 ◽  
Vol 52 (6) ◽  
pp. 713-719 ◽  
Author(s):  
Mark O Goodarzi ◽  
Stephen Erickson ◽  
Sidney C Port ◽  
Robert I Jennrich ◽  
Stanley G Korenman
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Relative Impact ◽  
Ovary Syndrome

Vascular abnormalities and low-grade chronic inflammation in women with polycystic ovary syndrome: Relationships with insulin resistance, obesity and hyperandrogenemia

Open Medicine ◽  
2008 ◽  
Vol 3 (3) ◽  
pp. 257-270 ◽  
Author(s):  
Ioana Ilie ◽  
Carmen Pepene ◽  
Ileana Duncea ◽  
Razvan Ilie
Keyword(s):  
Risk Factors ◽  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Low Grade ◽  
Ovary Syndrome ◽  
The Metabolic Syndrome

AbstractPolycystic ovary syndrome (PCOS) is possibly the most common endocrinopathy of reproductive age, characterized by hyperandrogenism and oligomenorrhea. Additionally, approximately one-third to one-half of all women and adolescent girls with PCOS tend to fulfill many of the metabolic syndrome criteria, and many view PCOS as a premetabolic syndrome condition, predisposing to a high risk for cardiovascular disease. Endothelial dysfunction, impaired arterial structure, or proinflammatory markers are early features of atherosclerosis, and can be used as surrogate indicators of future coronary artery disease in women with PCOS. However, as the latest studies show, these symptoms are the result of deleterious effects that cardiovascular risk factors, in particular insulin resistance and obesity, produce on the vascular wall, rather than to the presence of PCOS per se. The relationship between hyperandrogenemia and the risk of cardiovascular disease is controversial and needs to be clarified. Further research is warranted to understand the pathogenesis of cardiovascular disease in PCOS, and to identify subtypes of PCOS in which the presence of cardiovascular risk factors may result in increased cardiovascular events, leading to high morbidity or mortality rates caused by cardiovascular disease.

Cardiovascular risk factors in polycystic ovary syndrome

2005 ◽  
Vol 113 (S 1) ◽  
Author(s):  
S Tan ◽  
S Hahn ◽  
K Pleger ◽  
S Sack ◽  
BL Herrmann ◽  
...  
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Polycystic Ovary Syndrome ◽  
Cardiovascular Risk Factors ◽  
Polycystic Ovary ◽  
Ovary Syndrome
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