scholarly journals Usefulness of Hybrid Surgery Combining CEA and CAS for Carotid Artery Stenosis with a Large Amount of Vulnerable Plaque

2021 ◽  
Author(s):  
Yoshinobu Sekihara ◽  
Yuzo Saito ◽  
Yoshiyuki Takada ◽  
Norihiro Ishii
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Vulnerable Plaque ◽  
Artery Stenosis ◽  
Hybrid Surgery

scholarly journals Therapeutic Outcome for Symptomatic Low-grade Carotid Artery Stenosis with Vulnerable Plaque

2015 ◽  
Vol 43 (2) ◽  
pp. 98-102 ◽  
Author(s):  
Yoshitaka KUROSAKI ◽  
Kazumichi YOSHIDA ◽  
Hitoshi FUKUDA ◽  
Nobutake SADAMASA ◽  
Akira HANDA ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Vulnerable Plaque ◽  
Therapeutic Outcome ◽  
Artery Stenosis ◽  
Low Grade

Abstract 2352: 18F-fluorodeoxyglucose PET Can Identify The Inflamed and Vulnerable Carotid Plaque - A Prospective Study in Japan

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
Satoshi Kuroda ◽  
Hisayasu Saito ◽  
Katsuhiko Maruichi ◽  
Naoki Nakayama ◽  
Kenji Hirata ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Prospective Study ◽  
Carotid Artery Stenosis ◽  
Fdg Pet ◽  
Vulnerable Plaque ◽  
Japanese Patients ◽  
Artery Stenosis ◽  
Fdg Uptake ◽  
Standardized Uptake Values ◽  
18F Fdg

Objective - There are few studies that denote the validity of 8F-fluorodeoxyglucose (FDG) PET to detect the inflammation of severe (>70%) carotid artery stenosis in Asian populations. This study was aimed to clarify whether 18F-FDG PET can identify inflamed and vulnerable plaque at higher risk for subsequent ischemic stroke in Japanese patients with severe carotid artery stenosis. Methods - This prospective study included 33 patients with severe carotid artery stenosis between 2006 and 2011. Of these, 12 patients were symptomatic and other 21 were asymptomatic. There were 28 males and 5 females. Their mean age was 71.1 ± 8.2 years, ranging from 48 to 85. Their clinical data were precisely collected. All 33 patients underwent 18F-FDG PET and ultrasound sonography (US) to evaluate the plaque composition prior to carotid endarterectomy (CEA). FDG uptake was quantified by maximum standardized uptake values (SUV). Following surgery, the specimens were stained with the antibodies against CD68 and MMP-9. Results - High FDG uptake (SUV>2.0) was observed in 15 (45%) of 33 operated plaques. High FDG uptake significantly correlated with the other vascular disorders (P=0.048), echolucent plaque (P=0.041), lipid-rich plaque (P<0.001), CD68 expression (P<0.001), and MMP-9 expression (P=0.002). 18F-FDG PET showed significantly higher sensitivity and specificity to identify lipid-rich and CD68-positive plaque than US. However, high FDG uptake was not related to patients’ gender, age, and the degree of stenosis. There was no significant correlation between FDG uptake and symptomatic or asymptomatic patients. Conclusion - These findings strongly suggest that 18F-FDG PET would provide more valuable information to identify the inflamed, vulnerable plaque than conventional ultrasound in Japanese patients with severe carotid artery stenosis.

scholarly journals Soluble ST2 levels are not associated with secondary cardiovascular events and vulnerable plaque phenotype in patients with carotid artery stenosis

2013 ◽  
Vol 231 (1) ◽  
pp. 48-53 ◽  
Author(s):  
Sanne Willems ◽  
Paul H.A. Quax ◽  
Gert Jan de Borst ◽  
Jean-Paul P.M. de Vries ◽  
Frans L. Moll ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Vulnerable Plaque ◽  
Cardiovascular Events ◽  
Artery Stenosis ◽  
Soluble St2 ◽  
Plaque Phenotype

Novel serum biomarkers in carotid artery stenosis: Useful to identify the vulnerable plaque?

2011 ◽  
Vol 44 (16) ◽  
pp. 1292-1298 ◽  
Author(s):  
Linda Hermus ◽  
Joost H.N. Schuitemaker ◽  
Rene A. Tio ◽  
Jan Cees Breek ◽  
Riemer H.J.A. Slart ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Vulnerable Plaque ◽  
Serum Biomarkers ◽  
Artery Stenosis

scholarly journals Circulating Immunoglobulins Are Not Associated with Intraplaque Mast Cell Number and Other Vulnerable Plaque Characteristics in Patients with Carotid Artery Stenosis

PLoS ONE ◽  
2014 ◽  
Vol 9 (2) ◽  
pp. e88984 ◽  
Author(s):  
Sanne Willems ◽  
Daniël van der Velden ◽  
Paul H. A. Quax ◽  
Gert Jan de Borst ◽  
Jean-Paul P. M. de Vries ◽  
...  
Keyword(s):  
Mast Cell ◽  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Vulnerable Plaque ◽  
Cell Number ◽  
Artery Stenosis ◽  
Mast Cell Number

Oxidative injury associated with stenting of asymptomatic carotid artery stenosis

VASA ◽  
2017 ◽  
Vol 46 (4) ◽  
pp. 268-274
Author(s):  
Erhan Saraçoğlu ◽  
Ertan Vuruşkan ◽  
Yusuf Çekici ◽  
Salih Kiliç ◽  
Halil Ay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carotid Artery ◽  
Oxidative Damage ◽  
Carotid Artery Stenosis ◽  
Artery Stenosis ◽  
Oxidative Stress Marker ◽  
Asymptomatic Carotid ◽  
Imaging Methods ◽  
Neurological Findings ◽  
Asymptomatic Carotid Artery Stenosis

Abstract. Background: After carotid artery stenting (CAS), neurological complications that cannot be explained with imaging methods may develop. In our study we aimed to show, using oxidative stress markers, isolated oxidative damage and resulting neurological findings following CAS in patients with asymptomatic carotid artery stenosis. Patients and methods: We included 131 neurologically asymptomatic patients requiring CAS. The neurological findings were evaluated using the modified Rankin Scale (mRS) prior to the procedure, one hour post-procedure, and two days after. Patients with elevated mRS scores but with or without typical hyperintense lesions observed on an MRI and with changes of oxidative stress marker levels at the time (Δtotal-thiol, Δtotal antioxidative status [TAS], and Δtotal oxidant status [TOS]) were evaluated. Results: In the neurological examination carried out one hour prior to the procedure, there were 92 patients with mRS = 0, 20 with mRS = 1, and 12 with mRS = 2. When Δtotal-thiol, ΔTAS, and ΔTOS values and the mRS were compared, it was observed that as the difference in oxidative parameters increased, clinical deterioration also increased proportionally (p = 0.001). Conclusions: We demonstrate a possible correlation between oxidative damage and neurological findings after CAS which could not be explained by routine imaging methods.

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