Left Ventricular Regional Wall Motion Abnormality in the Setting of Acute Loperamide Overdose

Loperamide is an inexpensive, over-the-counter antidiarrheal agent with emerging reports of overdose due to its opioid properties. Although it is considered by many patients to be safe, cardiotoxicity has been reported, prompting the United States Food and Drug Administration to release a warning regarding the arrhythmogenic potential of loperamide. We present a case of a 32-year-old male presenting in acute loperamide overdose and subsequent cardiac dysrhythmia with focal wall motion abnormalities on echocardiogram. This finding has not been previously reported in the literature and is unique in this clinical presentation. We also highlight the potential mechanisms for loperamide cardiotoxicity and its challenging management.

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Takotsubo Cardiomyopathy in a Squash Player

Cardiology Research and Practice ◽

10.4061/2009/351621 ◽

2009 ◽

Vol 2009 ◽

pp. 1-4 ◽

Cited By ~ 2

Author(s):

Mathieu Berry ◽

Jerome Roncalli ◽

Olivier Lairez ◽

Meyer Elbaz ◽

Didier Carrié ◽

...

Keyword(s):

Takotsubo Cardiomyopathy ◽

Wall Motion ◽

Ventricular Dysfunction ◽

Apical Ballooning ◽

Regional Wall Motion ◽

Left Ventricular ◽

The Body ◽

Coronary Syndrome ◽

Regional Wall Motion Abnormalities ◽

Wall Motion Abnormalities

Takotsubo cardiomyopathy is usually described following acute emotional stress. We report here the case of a 48-year-old woman admitted for acute coronary syndrome after an intensive squash match. Diagnosis of Takotsubo cardiomyopathy due to acute physical stress was suspected in presence of normal coronary arteries and transitory left ventricular dysfunction with typical apical ballooning. Cardiac magnetic resonance imaging confirmed regional wall-motion abnormalities and was helpful in excluding myocardial infarction diagnosis. During squash the body is subject to sudden and vigorous demands inducing a prolonged and severe workload on the myocardium.

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166 Importance of left ventricular remodelling and regional wall motion abnormalities in the occurrence of functional ischemic mitral regurgitation

Archives of Cardiovascular Diseases Supplements ◽

10.1016/s1878-6480(12)70562-1 ◽

2012 ◽

Vol 4 (1) ◽

pp. 52-53

Author(s):

Leila Bezdah ◽

Emna Allouche ◽

Chadia Chourabi ◽

Wafa Falah ◽

W. Ouechtati ◽

...

Keyword(s):

Mitral Regurgitation ◽

Wall Motion ◽

Regional Wall Motion ◽

Left Ventricular ◽

Ischemic Mitral Regurgitation ◽

Ventricular Remodelling ◽

Left Ventricular Remodelling ◽

Regional Wall ◽

Regional Wall Motion Abnormalities ◽

Wall Motion Abnormalities

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105: Left ventricular remodelling and regional wall motion abnormalities as determinants of functional ischemic mitral regurgitation

Archives of Cardiovascular Diseases Supplements ◽

10.1016/s1878-6480(13)71035-8 ◽

2013 ◽

Vol 5 (1) ◽

pp. 34-35

Author(s):

Leila Bazdah ◽

Emna Allouche ◽

Hédi Baccar ◽

Wejdène Ouechtati ◽

Slim Sidhom ◽

...

Keyword(s):

Mitral Regurgitation ◽

Wall Motion ◽

Regional Wall Motion ◽

Left Ventricular ◽

Ischemic Mitral Regurgitation ◽

Ventricular Remodelling ◽

Left Ventricular Remodelling ◽

Regional Wall ◽

Regional Wall Motion Abnormalities ◽

Wall Motion Abnormalities

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Echocardiographic assessment of left ventricular function in patients of acute myocardial infarction

International Journal of Advances in Medicine ◽

10.18203/2349-3933.ijam20173070 ◽

2017 ◽

Vol 4 (4) ◽

pp. 926

Author(s):

Anjali V. Shivpuje ◽

Shrikant Page

Keyword(s):

Myocardial Infarction ◽

Acute Myocardial Infarction ◽

Wall Motion ◽

Health Centre ◽

Regional Wall Motion ◽

Left Ventricular ◽

Lv Function ◽

Regional Wall ◽

Wall Motion Abnormalities ◽

Echocardiographic Assessment

Background:2D Echo can evaluate LV anatomy, function and diagnose post AMI complications in early stages, thus help in management and determining the prognosis. The present study was undertaken to evaluate LV function in patient following AMI and also to find out the incidence of various echocardiographically detectable complications of following AMI.Methods: The present study was conducted on patients visiting our tertiary health centre during study duration. 50 patients were included in the study. Patients with prior history of acute myocardial infarction, pericarditis and early repolarisation syndrome, and primary myocardial disease diagnosed by serum enzyme levels were not included in the study. Patients were classified as per Killip classification and 2D echo study was performed in all patients.Results: Maximum incidence of AMI was found in 51-60 years of age, with male predominance (64%). Anterior wall AMI (58%) was more common. 94% of patients had wall motion abnormalities. Incidence of LV thrombus was found to be 24%. In present study, as the extent and severity of wall motion abnormalities increased, the incidence of LV thrombus also increased. Thus, 2DE study of LV regional wall motion can predict the incidence of LV thrombus.Conclusions: The echocardiographic assessment of LV function in patients of AMI is important as, it detects the regional wall motion abnormality, LVEF and also the complications like LV thrombus, pericardial effusion and LV aneurysm. These observations are of great value in the management of AMI.

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Editor’s Choice- Pathophysiology, diagnosis and management of MINOCA: an update

European Heart Journal Acute Cardiovascular Care ◽

10.1177/2048872618782414 ◽

2018 ◽

Vol 8 (1) ◽

pp. 54-62 ◽

Cited By ~ 36

Author(s):

Giancarla Scalone ◽

Giampaolo Niccoli ◽

Filippo Crea

Keyword(s):

Myocardial Infarction ◽

Coronary Artery ◽

Coronary Arteries ◽

Wall Motion ◽

Regional Wall Motion ◽

Left Ventricular ◽

Regional Wall ◽

Diagnosis And Management ◽

Regional Wall Motion Abnormalities ◽

Wall Motion Abnormalities

Myocardial infarction with non-obstructive coronary arteries (MINOCA) is a syndrome with different causes, characterised by clinical evidence of myocardial infarction with normal or near-normal coronary arteries on angiography. Its prevalence ranges between 5% and 25% of all myocardial infarction. The prognosis is extremely variable, depending on the cause of MINOCA. The key principle in the management of this syndrome is to clarify the underlying individual mechanisms to achieve patient-specific treatments. Clinical history, electrocardiogram, cardiac enzymes, echocardiography, coronary angiography and left ventricular angiography represent the first level diagnostic investigations to identify the causes of MINOCA. Regional wall motion abnormalities at left ventricular angiography limited to a single epicardial coronary artery territory identify an ‘epicardial pattern’whereas regional wall motion abnormalities extended beyond a single epicardial coronary artery territory identify a ‘microvascular pattern’. The most common causes of MINOCA are represented by coronary plaque disease, coronary dissection, coronary artery spasm, coronary microvascular spasm, Takotsubo cardiomyopathy, myocarditis, coronary thromboembolism, other forms of type 2 myocardial infarction and MINOCA of uncertain aetiology. This review aims at summarising the diagnosis and management of MINOCA, according to the underlying physiopathology.

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