The Relationship Between Emotional Functioning of the EORTC QLQ-C30 and A Measure of Anxiety and Depression (HADS) in Cancer Patients

Abstract Purpose Cancer is of increasing prevalence in less-developed countries. However, research on the patients’ quality of life (QoL) in these countries is very limited. The aim of this study was to examine QoL of cancer patients in Africa. Method A sample of 256 cancer patients treated in an Ethiopian hospital was examined with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire EORTC QLQ-C30, the Multidimensional Fatigue Inventory, and the Hospital Anxiety and Depression Scale. A group of 1664 German cancer patients served as a comparison group. Results Most of the scales of the EORTC QLQ-C30 showed acceptable reliability in the Ethiopian sample. Compared with the German cancer patients, the Ethiopian patients showed lower QoL in most dimensions, especially in financial difficulties, physical functioning, pain, and appetite loss (effect sizes between 0.52 and 0.75). Illiteracy, tumor stage, and treatment (surgery and chemotherapy) were associated with QoL in the Ethiopian sample. QoL was strongly correlated with fatigue, anxiety, and depression. Conclusion The EORTC QLQ-C30 is a suitable instrument for measuring QoL in Ethiopia. The detriments in QoL in the Ethiopian patients indicate specific cancer care needs for the patients in a developing country.

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The relationship between global and specific components of quality of life, assessed with the EORTC QLQ-C30 in a sample of 2019 cancer patients

European Journal of Cancer Care ◽

10.1111/ecc.12416 ◽

2015 ◽

Vol 26 (2) ◽

pp. e12416 ◽

Cited By ~ 12

Author(s):

A. Hinz ◽

A. Mehnert ◽

C. Dégi ◽

D.R. Reissmann ◽

D. Schotte ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Eortc Qlq C30 ◽

Eortc Qlq ◽

The Relationship

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Spanish General Population Normative Data Analysis for the EORTC QLQ-C30 and Relationships Between Sex, Age, and Health Conditions

10.21203/rs.3.rs-325320/v1 ◽

2021 ◽

Author(s):

Juan Ignacio Arraras ◽

Sandra Nolte ◽

Gregor Liegl ◽

Matthias Rose ◽

Ana Manterola ◽

...

Keyword(s):

General Population ◽

Cancer Patients ◽

Normative Data ◽

Population Distribution ◽

Emotional Functioning ◽

Health Condition ◽

Health Conditions ◽

European Organization ◽

Eortc Qlq C30 ◽

Eortc Qlq

Abstract PurposeGeneral population normative data for the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aimed to present normative data of the Spanish general population.Methods/Patients Data were obtained from a prior larger study collecting EORTC QLQ-C30 norm data across 15 countries. Data were stratified by sex and age groups (18–39, 40–49, 50–59, 60–69 and >70 years). Sex and age distribution were weighted according to population distribution statistics. Sex- and age-specific normative values were analysed separately, as were participants with versus those without health conditions. Multiple linear regression was used to estimate the association of each of the EORTC QLQ-C30 scales with the determinants age, sex, sex-by-age interaction term, and health condition. Results 1165 Spanish individuals participated in the study. Differences were found by sex and age. The largest sex-related differences were seen in fatigue, emotional functioning, and global QoL (Quality of Life), favouring men. Largest age differences were seen in emotional functioning, insomnia, and pain, with middle-aged groups having the worst scores. Those >60 years scored better than those <60 years on all scales except for physical functioning. Participants with no health conditions scored better in all QLQ-C30 domains.ConclusionsThe present study highlights differences in HRQoL between specific sex/age strata and especially between persons with and without a health condition in the Spanish general population. These factors must be considered when comparing general population HRQoL data with that of cancer patients.

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The Hospital Anxiety and Depression Scale (HADS) applied to Ethiopian cancer patients

PLoS ONE ◽

10.1371/journal.pone.0243357 ◽

2020 ◽

Vol 15 (12) ◽

pp. e0243357

Author(s):

Yemataw Wondie ◽

Anja Mehnert ◽

Andreas Hinz

Keyword(s):

Cancer Patients ◽

Depression Scale ◽

Psychosocial Care ◽

Tumor Stage ◽

Anxiety And Depression ◽

Life Questionnaire ◽

Hospital Anxiety ◽

European Organization ◽

Eortc Qlq C30 ◽

Eortc Qlq

Psychological distress is a common problem associated with cancer. The main objective of the present study was to test the Hospital Anxiety and Depression Scale (HADS) in a sample of Ethiopian cancer patients and to compare the results with those obtained from a sample in Germany. Data were collected from 256 cancer patients who visited the University of Gondar Hospital between January 2019 and June 2019 using the HADS, the European Organization for Research and Treatment of Cancer Quality of Life questionnaire (EORTC QLQ-C30), and the Multidimensional Fatigue Inventory MFI-20. The reliability of the HADS was good, with Cronbach’s α coefficients of 0.86 (anxiety), 0.85 (depression), and 0.91 (total scale). The Ethiopian cancer patients were more anxious (M = 7.9) and more depressed (M = 9.3) than the German patients (M = 6.8 for anxiety and M = 5.5 for depression). Only a weak level of measurement invariance was detected between the Ethiopian and the German sample. In the Ethiopian sample, anxiety and depression were associated with tumor stage (high levels in stage 4) and treatment (high levels for patients not receiving surgery and chemotherapy). Both anxiety and depression were significantly associated with all of the EORTC QLQ-C30 and MFI-20 scales. The HADS proved to be applicable for use with Ethiopian cancer patients. The high level of anxiety and depression present in that group indicates a need for psychosocial care.

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General Spanish population normative data analysis for the EORTC QLQ-C30 by sex, age, and health condition

Health and Quality of Life Outcomes ◽

10.1186/s12955-021-01820-x ◽

2021 ◽

Vol 19 (1) ◽

Author(s):

Juan Ignacio Arraras ◽

Sandra Nolte ◽

Gregor Liegl ◽

Matthias Rose ◽

Ana Manterola ◽

...

Keyword(s):

General Population ◽

Cancer Patients ◽

Normative Data ◽

Population Distribution ◽

Emotional Functioning ◽

Health Condition ◽

Spanish Population ◽

Health Conditions ◽

Eortc Qlq C30 ◽

Eortc Qlq

Abstract Purpose General population normative data for the European Organisation for Research and Treatment of Cancer (EORTC) QLQ-C30 questionnaire facilitates interpretation of data assessed from cancer patients. This study aims to present normative data of the general Spanish population. Methods/patients Data were obtained from a prior larger study collecting EORTC QLQ-C30 norm data across 15 countries. Data were stratified by sex and age groups (18–39, 40–49, 50–59, 60–69 and > 70 years). Sex and age distribution were weighted according to population distribution statistics. Sex- and age-specific normative values were analysed separately, as were participants with versus those without health conditions. Multiple linear regression was used to estimate the association of each of the EORTC QLQ-C30 scales with the determinants age, sex, sex-by-age interaction term, and health condition. Results In total, 1,165 Spanish individuals participated in the study. Differences were found by sex and age. The largest sex-related differences were seen in fatigue, emotional functioning, and global QOL (Quality of Life), favouring men. The largest age differences were seen in emotional functioning, insomnia, and pain, with middle-aged groups having the worst scores. Those > 60 years old scored better than those < 60 years old on all scales except for physical functioning. Participants with no health conditions scored better in all QLQ-C30 domains. Conclusions The present study highlights differences in HRQOL between specific sex/age strata and especially between people with and without a health condition in the general Spanish population. These factors must be considered when comparing general population HRQOL data with that of cancer patients.

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POS0291 THE IMPACT OF DRUG INDUCED AND OTHER RHEUMATIC MUSCULOSKELETAL DISORDERS (MD) ON THE QUALITY OF LIFE (QOL) OF CANCER PATIENTS RECEIVED ANTICANCER DRUG TREATMENT

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.2286 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 371.1-371

Author(s):

A. Koltakova ◽

A. Lila ◽

L. P. Ananyeva ◽

A. Fedenko

Keyword(s):

Drug Treatment ◽

Cancer Patients ◽

Anticancer Drug ◽

Physical Functioning ◽

Role Functioning ◽

Drug Induced ◽

Significant Difference ◽

Eortc Qlq C30 ◽

Eortc Qlq ◽

The Impact

Background:Pts with cancer may have MD that can be caused by neoplastic/paraneoplastic disease, rheumatic diseases or be induced by anticancer drug treatment. There is no data about MD influence on the QoL of cancer patients. The EORTC QoL questionnaire (QLQ)-C30 is a valid questionnaire designed to assess different aspects (Global health (GH), Functional (FS) and symptoms (SS) scales) that define the QoL of cancer patients [1].Objectives:The objective of the study was to assess the impact of drug induced and other types of MD on the QoL of cancer patients that received anticancer drug treatment by using of EORTC QLQ-C30 v3.0.Methods:The sampling of 123 pts (M/F – 40/83; mean age 54.4±12.8) with breast (32,5%), gastrointestinal (17%), ovary (8%), lung (7%) and other cancer was observed by rheumatologist in the oncology outpatient clinic. All pts received anticancer drug treatment: chemotherapy (104 pts), target therapy (16 pts) checkpoint-inhibitors (14 pts), hormone therapy (13 pts) in different combinations. 102(82.9%) of 123pts had MD include arthritis (12 pts), synovitis (5 pts), arthralgia (66 pts), periarthritis (34 pts), osteodynia (13 pts). There were 58 pts (group 1; M/F – 14/44; mean age 52.5±12.2) with anticancer drug treatment induced MD and 44 pts (group 2; M/F – 16/27; mean age 57.6±13.5) with other type of MD include 26 pts with skeletal metastasis. The were 21 pts (group 3; M/F – 10/11; mean age 52.9±11.1) without MD. All pts fulfilled EORTC QLQ-C30 v3.0 (tab.1).Table 1.The median [Q1;Q3] of results of GH, SS and SS of EORTC QLQ-C30ScaleSubscaleGroup1Group2Group3GH58.3[50;58]58.3[41.7;83.3]50[50;66.7]FS*Physical functioning73.3[60;86.7]73.3[66.7;86.7]86.7[80;93]Role functioning66.7[66.7;100]83.3[50;100]100[83;100]Emotional functioning83.3[66.7;100]75[66.7;91.7]91.6[83.3;100]Social functioning83.3[66.7;100]83.3[50;100]100[83.3;100]SS*Pain33.3[0;50]16.7[0;33.3]0[0;16.7]*There are only the scores that had got a statistical difference between the groups.Kruskal-Wallis H and post-hoc (Dwass-Steel-Critchlow-Fligner (DSCF) pairwise comparisons) tests for data analysis were performed.Results:A Kruskal-Wallis H test has shown a statistically significant difference in physical (χ2(2)=7.54; p=0.023), role (χ2(2)=9.87; p=0.007), emotion (χ2(2)=7.69; p=0.021) functioning and pain (χ2(2)=8.44; p=0.015) scores between the different groups. A post-hoc test with DSCF pairwise comparisons of median has shown a statistically significant difference between 1 and 3 groups (W=3.904; p=0.016) for physical functioning, between 2 and 3 groups (W=3.35; p=0.004) for role functioning, between 2 and 3 groups (W=4.03; p=0.012) for emotional functioning, between 1 and 3 groups (W=-3.97; p=0.014) for pain scale.Conclusion:The study has shown that MD associated with anticancer drug treatment adversely affected the QoL of cancer patients received anticancer drug treatment by reducing a physical functioning and by increasing pain scores. Presence of other types of MD adversely affect the QoL by reducing emotional and role functioning.References:[1]Aaronson NK,et al.The European Organization for Research and Treatment of Cancer QLQ-C30: a quality-of-life instrument for use in international clinical trials in oncology. J Natl Cancer Inst.1993;85(5):365-376. doi:10.1093/jnci/85.5.365Disclosure of Interests:None declared

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United States Utility Algorithm for the EORTC QLU-C10D, a Multiattribute Utility Instrument Based on a Cancer-Specific Quality-of-Life Instrument

Medical Decision Making ◽

10.1177/0272989x211003569 ◽

2021 ◽

pp. 0272989X2110035

Author(s):

Dennis A. Revicki ◽

Madeleine T. King ◽

Rosalie Viney ◽

A. Simon Pickard ◽

Rebecca Mercieca-Bebber ◽

...

Keyword(s):

Quality Of Life ◽

United States ◽

Emotional Functioning ◽

Health State ◽

Life Questionnaire ◽

Multiattribute Utility ◽

Value Set ◽

Eortc Qlq C30 ◽

Eortc Qlq

Background The EORTC QLU-C10D is a multiattribute utility measure derived from the cancer-specific quality-of-life questionnaire, the EORTC QLQ-C30. The QLU-C10D contains 10 dimensions (physical, role, social and emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems). The objective of this study was to develop a United States value set for the QLU-C10D. Methods A US online panel was quota recruited to achieve a representative sample for sex, age (≥18 y), race, and ethnicity. Respondents undertook a discrete choice experiment, each completing 16 choice-pairs, randomly assigned from a total of 960 choice-pairs. Each pair included 2 QLU-C10D health states and duration. Data were analyzed using conditional logistic regression, parameterized to fit the quality-adjusted life-year framework. Utility weights were calculated as the ratio of each dimension-level coefficient to the coefficient for life expectancy. Results A total of 2480 panel members opted in, 2333 (94%) completed at least 1 choice-pair, and 2273 (92%) completed all choice-pairs. Within dimensions, weights were generally monotonic. Physical functioning, role functioning, and pain were associated with the largest utility weights. Cancer-specific dimensions, such as nausea and bowel problems, were associated with moderate utility decrements, as were general issues such as problems with emotional functioning and social functioning. Sleep problems and fatigue were associated with smaller utility decrements. The value of the worst health state was 0.032, which was slightly greater than 0 (equivalent to being dead). Conclusions This study provides the US-specific value set for the QLU-C10D. These estimated health state scores, based on responses to the EORTC QLQ-C30 questionnaire, can be used to evaluate the cost-utility of oncology treatments.

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Predictive factors of overall quality of life in advanced cancer patients using EORTC QLQ-C30

Expert Review of Pharmacoeconomics & Outcomes Research ◽

10.1586/14737167.2014.864560 ◽

2013 ◽

Vol 14 (1) ◽

pp. 139-146 ◽

Cited By ~ 4

Author(s):

Gemma Cramarossa ◽

Liang Zeng ◽

Liying Zhang ◽

Ling-Ming Tseng ◽

Ming-Feng Hou ◽

...

Keyword(s):

Quality Of Life ◽

Cancer Patients ◽

Advanced Cancer ◽

Predictive Factors ◽

Advanced Cancer Patients ◽

Eortc Qlq C30 ◽

Eortc Qlq

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Understanding the reliability and validity of the EORTC QLQ-C30 in Turkish cancer patients

European Journal of Cancer Care ◽

10.1111/j.1365-2354.2007.00827.x ◽

2007 ◽

Vol 0 (0) ◽

pp. 071108171341007-??? ◽

Cited By ~ 5

Author(s):

E.S. CANKURTARAN ◽

E. OZALP ◽

H. SOYGUR ◽

S. OZER ◽

D.I. AKBIYIK ◽

...

Keyword(s):

Cancer Patients ◽

Reliability And Validity ◽

Eortc Qlq C30 ◽

Eortc Qlq

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Psychometric properties of the EORTC Quality of Life Questionnaire in inpatient cancer rehabilitation in Germany

Palliative & Supportive Care ◽

10.1017/s1478951504040179 ◽

2004 ◽

Vol 2 (2) ◽

pp. 115-124 ◽

Cited By ~ 6

Author(s):

JÖRG DIRMAIER ◽

SILKE ZAUN ◽

UWE KOCH ◽

TIMO HARFST ◽

HOLGER SCHULZ

Keyword(s):

Quality Of Life ◽

Psychometric Properties ◽

Cancer Patients ◽

Scale Structure ◽

Cancer Rehabilitation ◽

Life Questionnaire ◽

European Organization ◽

Eortc Qlq C30 ◽

Eortc Qlq

Objective: Recent years have shown an increase in the use of questionnaires measuring health-related quality of life to verify the quality of treatment in the field of oncology. An often used cancer-specific questionnaire is the “Quality of Life Core Questionnaire of the European Organization for the Research and Treatment of Cancer” (EORTC QLQ-C30). The purpose of this study is to analyze the psychometric properties of the EORTC QLQ-C30 (version 1) in order to determine the feasibility and appropriateness for its use in inpatient cancer rehabilitation in Germany with heterogeneous diagnoses.Methods: The questionnaire was administrated to a sample of 972 cancer patients at the beginning of treatment and to 892 patients after treatment. Besides descriptive analysis, the statistical analyses include confirmatory analysis and the multitrait/multimethod approach to test the questionnaire's postulated scale structure (factorial validity) and its reliability (internal consistencies). The analysis also includes a comparison of responsiveness indices (effect size, reliable change index) to test the sensitivity of the instrument.Results: The EORTC QLQ-C30 showed satisfactory levels of reliability and sensitivity, but the postulated scale structure could not be confirmed. The results illustrate that the varimax-rotated solution of a principal component analysis does not confirm the scale structure postulated by the authors. Correspondingly, the selected fit indices within the scope of the confirmatory factor analysis do not show satisfactory results either.Significance of results: We therefore consider version 1 of the EORTC QLQ-C30 to be only limitedly useful for the routine assessment of changes in the quality of life of cancer patients in inpatient rehabilitation in Germany, especially because of the instrument's length and possible redundancies. For this reason, a scoring procedure limited to a subset of items is suggested, revealing satisfactory to good psychometric indices. However, further psychometric tests are necessary, especially with regard to validity and sensitivity.

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