scholarly journals Effects of Alpha-Lipoic Acid Supplementation on Oxidative Stress Status in Patients with Non-Alcoholic Fatty Liver Disease: A Randomized, Double Blind, Placebo-Controlled Clinical Trial

2018 ◽  
Vol 20 (9) ◽  
Author(s):  
Farshad Amirkhizi ◽  
Soudabeh Hamedi-Shahraki ◽  
Sonya Hosseinpour-Arjmand ◽  
Elnaz Vaghef-Mehrabany ◽  
Mehrangiz Ebrahimi-Mameghani
Keyword(s):  
Oxidative Stress ◽  
Clinical Trial ◽  
Fatty Liver Disease ◽  
Controlled Clinical Trial ◽  
Alpha Lipoic Acid ◽  
Double Blind ◽  
Alcoholic Fatty Liver ◽  
Double Blind Placebo ◽  
Oxidative Stress Status ◽  
Alcoholic Fatty Liver Disease

scholarly journals Synbiotic supplementation in lean patients with non-alcoholic fatty liver disease: a pilot, randomised, double-blind, placebo-controlled, clinical trial

2017 ◽  
Vol 117 (5) ◽  
pp. 662-668 ◽  
Author(s):  
Fatemeh Mofidi ◽  
Hossein Poustchi ◽  
Zahra Yari ◽  
Babak Nourinayyer ◽  
Shahin Merat ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Placebo Group ◽  
Fatty Liver Disease ◽  
Controlled Clinical Trial ◽  
Double Blind ◽  
Alcoholic Fatty Liver ◽  
Double Blind Placebo ◽  
Low Bmi ◽  
Synbiotic Supplementation ◽  
Alcoholic Fatty Liver Disease

AbstractAlthough non-alcoholic fatty liver disease (NAFLD) is the leading aetiology of liver disorders in the world, there is no proven treatment for NAFLD patients with normal or low BMI. The aim of this study was to evaluate the efficacy of synbiotics supplementation in NAFLD patients with normal or low BMI. In this randomised, double-blind, placebo-controlled, clinical trial, fifty patients with NAFLD were assigned to take either a synbiotic supplement or a placebo capsule for 28 weeks. Both groups were advised to follow a healthy lifestyle. At the end of the study, hepatic steatosis and fibrosis reduced in both groups; however, the mean reduction was significantly greater in the synbiotic group rather than in the placebo group (P<0·001). Furthermore, serum levels of fasting blood sugar, TAG and most of the inflammatory mediators reduced in the synbiotic group significantly compared with the placebo group (P<0·05). Our results provide evidence that synbiotic supplementation improves the main features of NAFLD in patients with normal and low BMI, at least partially through reduction in inflammatory indices. Further studies are needed to address the exact mechanism of action of these effects.

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