scholarly journals DETERMINATION OF CEA IN THE DIAGNOSIS OF RECTAL CANCER AND THE RECURRENCE

1980 ◽  
Vol 13 (1) ◽  
pp. 58-62
Author(s):  
Akira OHASHI ◽  
Kiyoshi NISHIYAMA ◽  
Yoshihiro OMI ◽  
Hitoshi KANEKO ◽  
Shunsuke KOBAYASHI ◽  
...  
Keyword(s):  
Rectal Cancer

scholarly journals Comparison of MRI and colonoscopy in determining tumor height in rectal cancer

2017 ◽  
Vol 6 (1) ◽  
pp. 131-137 ◽  
Author(s):  
Lotte Jacobs ◽  
David B Meek ◽  
Joost van Heukelom ◽  
Thomas L Bollen ◽  
Peter D Siersema ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Intraclass Correlation ◽  
Rectal Tumor ◽  
Height Measurement ◽  
Treatment Allocation ◽  
Large Variability ◽  
Magnetic Resonance Imaging Mri ◽  
Preoperative Work Up ◽  
Work Up

Background and aim Endoscopy and magnetic resonance imaging (MRI) are used routinely in the diagnostic and preoperative work-up of rectal cancer. We aimed to compare colonoscopy and MRI in determining rectal tumor height. Methods Between 2002 and 2012, all patients with rectal cancer with available MRIs and endoscopy reports were included. All MRIs were reassessed for tumor height by two abdominal radiologists. To obtain insight in techniques used for endoscopic determination of tumor height, a survey among regional endoscopists was conducted. Results A total of 211 patients with rectal cancer were included. Tumor height was significantly lower when assessed by MRI than by endoscopy with a mean difference of 2.5 cm (95% CI: 2.1–2.8). Although the agreement between tumor height as measured by MRI and endoscopy was good (intraclass correlation coefficient (ICC) 0.7 (95% CI: 0.7–0.8)), the 95% limits of agreement varied from –3.0 cm to 8.0 cm. In 45 patients (21.3%), tumors were regarded as low by MRI and middle–high by endoscopy. MRI inter- and intraobserver agreements were excellent with an ICC of 0.8 (95% CI: 0.7–0.9) and 0.9 (95% CI: 0.9–1.0), respectively. The survey showed no consensus among endoscopists as to how to technically measure tumor height. Conclusion This study showed large variability in rectal tumor height as measured by colonoscopy and MRI. Since MRI measurements showed excellent inter- and intraobserver agreement, we suggest using tumor height measurement by MRI for diagnostic purposes and treatment allocation.

scholarly journals Determination of Operative Procedure Based on Preoperative Examination of Rectal Cancer.

1992 ◽  
Vol 25 (4) ◽  
pp. 1161-1165
Author(s):  
Hiroharu Isomoto ◽  
Kazuo Shirouzu ◽  
Tatsuhisa Morodomi ◽  
Yuichi Yamashita ◽  
Teruo Kakegawa
Keyword(s):  
Rectal Cancer ◽  
Operative Procedure ◽  
Preoperative Examination

scholarly journals Histological processing variability in the determination of lateral resection margins in rectal cancer

2007 ◽  
Vol 60 (6) ◽  
pp. 593-595 ◽  
Author(s):  
I Eid ◽  
M S El-Muhtaseb ◽  
R Mukherjee ◽  
R Renwick ◽  
D S Gardiner ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Resection Margins ◽  
Histological Processing

scholarly journals Complications Associated With Postoperative Adjuvant Radiation Therapy for Advanced Rectal Cancer

2014 ◽  
Vol 99 (2) ◽  
pp. 100-105 ◽  
Author(s):  
Koji Komori ◽  
Kenya Kimura ◽  
Takashi Kinoshita ◽  
Tsuyoshi Sano ◽  
Seiji Ito ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Therapy ◽  
Late Onset ◽  
Advanced Rectal Cancer ◽  
Late Complications ◽  
Adjuvant Radiation ◽  
Curative Surgery ◽  
Adjuvant Radiation Therapy ◽  
Pelvic Radiation

Abstract Preoperative management of advanced rectal cancer often includes chemoradiotherapy, but little is known about the late complications of radiotherapy. However, these are usually serious, making determination of the characteristics of late complications after radiation therapy critical. Accordingly, we investigated the complications occurring after adjuvant pelvic radiation therapy in patients with advanced rectal cancer. We enrolled 34 consecutive patients with TNM stage III rectal cancer who had undergone curative surgery with adjuvant pelvic radiation therapy. Data on the type of complication/organ involved, the number of complications, the phase of onset, and the treatments used were reviewed. Patients who experienced gut complications or edema were less likely to have their complications resolved than those with complications due to infection. Similarly, patients with multiple complications and late-onset complications were also less likely to have their complications resolved than those with single complications and those with early-onset complications, respectively. Adjuvant radiation therapy in patients with resected advanced rectal cancer was associated with various complications, characterized by late onset and impaired resolution. Therefore, patients indicated for radiation therapy should be selected with great caution.

scholarly journals Better prognostic determination of cT3 rectal cancer through measurement of distance to mesorectal fascia: A multicenter study

2021 ◽  
Vol 33 (5) ◽  
pp. 606-615
Author(s):  
Xiaoyan Zhang ◽  
◽  
Qiaoyuan Lu ◽  
Xiangjie Guo ◽  
Wuteng Cao ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Multicenter Study ◽  
Mesorectal Fascia

scholarly journals Role of Imaging in Rectal Cancer

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 4-6
Author(s):  
Ajaz Ahmad Malik
Keyword(s):  
Rectal Cancer ◽  
Rectal Wall ◽  
Preoperative Staging ◽  
Positron Emission ◽  
Adjacent Structures ◽  
Tumor Involvement ◽  
Magnetic Resonance Imaging Mri ◽  
Optimal Treatment Strategy

THIS ARTICLE HAS NO ABSTRACT (FIRST 100 WORDS OF THE ARTICLE ARE DISPLAYED): Staging of rectal cancer is necessary to provide the optimal treatment strategy although proctoscopy or sigmoidoscopy with biopsy are diagnostic. This is achieved by locoregional assessment of the disease by various available radiological investigations. Staging information includes extent of tumor involvement of the rectal wall and adjacent structures, presence or absence of adjacent lymphadenopathy, and determination of distant metastasis. Several modalities exist for the preoperative staging of rectal cancer, like computed tomography (CT); magnetic resonance imaging (MRI) with traditional body, endorectal, or phasedarray coils; endorectal ultrasonography (ERUS) with rigid or flexible probes; and positron emission tomography (PET) with and without. JMS 2012;15(1):4-6.

Determination of protein synthesis in human rectal cancer in situ by continuous [1-13C]leucine infusion

1997 ◽  
Vol 272 (5) ◽  
pp. E796-E802 ◽  
Author(s):  
W. H. Hartl ◽  
H. Demmelmair ◽  
K. W. Jauch ◽  
H. L. Schmidt ◽  
B. Koletzko ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Rectal Cancer ◽  
Protein Synthesis ◽  
Tumor Tissue ◽  
Normal Mucosa ◽  
Constant Infusion ◽  
Precursor Pool ◽  
Arterial Blood

Previous studies on human colorectal tumor protein synthesis in situ relied on techniques that required intra- or perioperative sampling to obtain a sufficient biopsy size. The purpose of the present study was to develop a new technique by use of new mass spectrometry equipment [capillary gas chromatography (GC)-combustion isotope ratio mass spectrometry (IRMS)], which allows reduction of the necessary sampling size. Thereby, tumor sampling could be done via conventional rectosigmoidoscopy, excluding the need for further disturbing invasive measures. Fifteen postabsorptive patients with localized rectal cancer received a primed-constant infusion of [1-13C]leucine (0.16 mumol.kg-1.min-1 constant, 9.6 mumol/kg prime). Forceps biopsies were taken after 3 and 6 h. In five subjects, tumor tissue and normal mucosa were studied simultaneously. Determination of protein-bound leucine enrichment was done by GC-IRMS, and GC-quadrupole MS was used to determine tracer-to-tracee ratios (tracer/tracee) for free intracellular leucine. GC-MS data demonstrated achievement of a steady state in the precursor pool enrichment after 3 h of isotope infusion (tracer/tracee at 3 h: 6.34 +/- 0.46%, at 6 h: 6.58 +/- 0.38%). Calculation of tumor protein synthesis yielded a fractional synthetic rate (FSR) of 1.06 +/- 0.11%/h or 25.5 +/- 2.6%/day (range 12.0-37.1%/day). At any time, protein-bound leucine enrichment was significantly higher in tumor tissue than in normal mucosa of the same subject. However, protein synthetic rates were comparable (tumor: 1.09 +/- 0.20%/h, mucosa: 1.29 +/- 0.28%/h). Thus combined GC-combustion IRMS and GC-/quadrupole MS provide a simple, reliable, and minimally invasive method to determine tumor FSR in situ, thereby excluding interferences common to previous methods. Tumor and mucosa tissues are similar with respect to protein synthesis, but they apparently differ with respect to leucine extraction from the arterial blood.

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