<p><strong>Objective:</strong> To evaluate the clinical effect of the treatment of exudative tuberculous pleurisy with central venous catheter drainage. <strong>Methods:</strong> 60 cases of exudative tuberculous pleurisy were divided into two groups. The treatment group was treatedwith central venous catheter drainage, while the control group was treated with multipleconventional thoracentesis. <strong>Results:</strong> The clinical effect of the treatment group was significantlyhigher in comparison to the control group (<em>p</em> < 0.01). The adverse reaction of the treatment group was significantly lower in contrast to the control group (<em>p</em> < 0.01). <strong>Conclusion:</strong> Application of central venous catheter drainage in the treatment of exudativetuberculous pleurisy revealed a positive effect, by showing less adverse reaction.Therefore, the treatment is worth to be promoted for clinical application.</p>