Discussion on the Effect of Introducing Clinical Pharmacists to Guide Clinical Medication in ICU

<p>Objective: to investigate the effect of clinical pharmacists in ICU. Methods: 108 ICU patients from January 2018 to March 2020 were divided into the control group and the observation group, with 54 cases in each group. The control group used the previous medication route, while the observation group introduced clinical pharmacists to guide clinical medication. The infection rate and adverse reaction rate of the two groups were compared. Results: the infection rate of the observation group was 3.70%, and that of the control group was 14.81%, which was significantly lower than that of the control group (P&lt;0.05). The adverse reaction rate of the observation group was 5.56%, and that of the control group was 18.52%, which was significantly lower than that of the control group (P&lt;0.05). Conclusion: the introduction of clinical pharmacists to guide clinical medication in ICU can effectively control the infection, and reduce various adverse reactions during drug use, so as to realize the scientific and standardized use of drugs, and improve the efficiency and safety of drug use.</p>

Relationship between Ambulatory Pulse Pressure, Pulse Pressure Index and Coronary Artery Disease in Patients with Hypertension

<p>Objective: To analyze the relationship between ambulatory pulse pressure, pulse pressure index, and coronary artery disease in patients with hypertension. Methods: From February 2018 to February 2019, a group of 100 patients with hypertension (control group) and a group of 100 patients with hypertension and coronary artery disease (experimental group) were selected to monitor and analyze dynamic pulse pressure and pulse pressure indicators. Results: In terms of clinical indicators, values of NPPI, 24hPP and 24hPPI in the experimental group were significantly higher than those in the control group. P &lt; 0.05 indicates that there is statistical value in the data difference. Conclusion: In the clinical diagnosis of hypertension patients, ambulatory pulse pressure, pulse pressure index are highly correlated with the risk of coronary artery disease. Therefore, researchers should actively pay attention to the relevant indicators of patients to lay a solid foundation for the effective protection of patients’ health.</p>

Development of NCOVID-19 Colloidal Gold Immunochromatographic Test Strip

<div><p>Purpose: To establish a fast, simple and accurate method and immunoassay test card for the detection of new coronavirus (nCOVID-19) antigen. Methods: In this study, colloidal gold immunochromatography technology was used to detect nCOVID-19 virus antigens through the sandwich method. At the same time, the preparation plan of colloidal gold was improved, and the application of rapid immune-diagnosis technology in other fields was developed. In this study, purified recombinant nCOVID-19 nucleocapsid protein is used as the antigen to prepare murine monoclonal antibodies. The BN02 antibody produced by the mouse is used as the detection antibody to couple with colloidal gold, forming a gold-labeled complex probe. BN9m1 is used as the coating antibody for the C-line, and ProA is used for the T-line. The polymerization of colloidal gold particles enables us to detect the new coronavirus antigen’s appearance. Thus an in vitro rapid detection kit for virus detection can be made. Results: The positive detection rate of the antigen quality control serum with this colloidal gold reagent was 100%. The specificity was 100%, and the sensitivity was 1ng/ml. Conclusion: The nCOVID-19 antigen detection reagent (colloidal gold method) developed in this research has high specificity and sensitivity, and can be used in conjunction with nucleic acid detection. As a means of detecting nCOVID-19, it can achieve qualitative and rapid screening of samples with advantage such as accuracy, repeatability, and low cost.</p></div>

Application Effect of Limited Fluid Resuscitation in Emergency Patients with Multiple Trauma Complicated with Shock

<p>This article explores the methods and effects of limited fluid resuscitation in the treatment of hemorrhagic shock caused by multiple trauma, which is common in clinic. 80 patients with multiple trauma complicated with shock were randomly selected from the emergency department of our hospital and divided into the observation group and the control group, with 40 members in each group. Patients in the observation group were treated with limited fluid resuscitation, while those in the control group were treated with aggressive fluid resuscitation. By comparing the therapeutic effects of the two groups, it is concluded that the therapeutic effect of the observation group is significantly better than that of the control group. Therefore, adopting limited fluid resuscitation in the clinical treatment of patients with multiple trauma complicated with shock can realize faster recovery, as well as protect patients’ coagulation function, effectively reducing complications and mortality. Moreover, it can also reduce the injury of trauma perfusion to the body, ensuring the recovery of patients.</p>

Efficacy Assessment of Emergency Percutaneous Coronary Intervention (PCI) for Acute Myocardial Infarction (AMI)

<p>Objective: To assess the clinic effect of percutaneous coronary intervention in the treatment of acute myocardial infarction. Methods: 90 patients with acute myocardial infarction in our hospital were chosen to be research objects and they were divided into two groups: control group and research group. Patients in control group were only treated by thrombolytic therapy while those in research group were further treated by percutaneous coronary intervention on the basis of this treatment. Result: The efficacy of research group was higher than that in control group. The incidence of adverse events was 4.44%, which is lower than that in control group. Conclusion: We should effectively apply percutaneous coronary intervention in treating acute myocardial infarction so as to improve the cardiac function of the patients. In addition, this treatment is safer and will lower the incidence of heart and renal failure.</p>

Effect of Cefazolin Sodium on Perioperative Prophylactic Anti-Infection in Patients Undergoing Gynecological Surgery

<p>Purpose: The purpose is to investigate the effect of cefazolin sodium on perioperative prophylactic anti-infection in patients undergoing gynecological surgery. Methods: 112 cases of gynecological surgery from January 2019 to April 2020 were divided into the control group and the observation group, with 56 cases in each group. They were given cefazolin sodium + metronidazole and cefazolin sodium monotherapy respectively. The perioperative white blood cells and the incidence of adverse reactions of the two groups were compared. Results: There was no difference in the normal rate of white blood cell count between the observation group and the control group (P &gt; 0.05), and no adverse reaction in the observation group, which was significantly lower than 7.14% in the control group (P &lt; 0.05). Conclusion: the use of cefazolin sodium in perioperative period of gynecological surgery can prevent infection, with advanced security, less adverse reactions and high value.</p>

Application of Microscrew Implant Anchorage in Orthodontics

Objective: To study the value of microscrew implant anchorage in orthodontic treatment. Methods: A total of 80 cases received orthodontic treatment in recent two years were selected and divided into experimental group and control group based on their received orthodontic measures, each group contains 40 cases. The control group was treated with general orthodontic treatment plan, while the study group received microscrew implant anchorage for the treatment. The clinical conditions of the two groups were counted and observed. Results: After different treatments, the effect of the study group was significantly better than that of the control group. All the indicators (including the improvement of molar displacement, incisor inclination angle and incisor convex distance) were available. In addition, there are obvious differences between the two groups in the occurrence of adverse reactions including inflammatory reaction, soft tissue edema and discomfort. Conclusion: In oral clinic, microscrew implant anchorage can achieve ideal curative effect for those who need orthodontics. Besides, its safety is relatively high, which is worth popularizing widely.

Application Value of Coagulation Function Test in Prognosis of Patients with Cardiovascular and Cerebrovascular Diseases

<p><span lang="EN-US">Objective: to explore the application value of coagulation function test in the prognosis of patients with cardiovascular and cerebrovascular diseases. Methods: from December 2018 to December 2019, 100 patients with cardiovascular and cerebrovascular diseases were randomly selected as the study group. According to the follow-up results of patients, they were divided into study group A (good prognosis, n = 64) and study group B (disability or death, n = 36) 100 subjects served as the control group. The test results of coagulation function of the two groups were analyzed retrospectively. The test results of the study group before and after treatment were compared with those of the control group, and the test results of the study group A and study group B after treatment were compared. Results: the coagulation function of the study group after treatment was significantly improved compared with that before treatment (P &lt; 0.05), and there was a significant difference between the two groups before treatment (P &lt; 0.05), and there was no difference after treatment (P &gt; 0.05); after treatment, the coagulation function of study group A and study B was significantly different (P &lt; 0.05). Conclusion: coagulation function test has a certain application value for the prognosis of patients with cardiovascular and cerebrovascular diseases, and can be used as an index to judge the patient’s condition and treatment effect, which has good application value in clinical practice.</span></p>

Development Predicament and Countermeasures of Anti-tumor Bio-similar Industry in China

<p><span lang="EN-US">Biosimilar has the advantages of precise efficacy, high safety and stable quality, and occupy an important position in the field of anti-tumor therapy. In order to reduce the expenditure of drugs, the research and development of biosimilar drugs has attracted much attention. Compared with European and American countries in the development of the anti-tumor biosimilar industry, there are still some shortcomings and parts that need improvement in China. According to the current development status of China, analyzed the reasons for the development dilemma of my country’s anti-tumor biosimilar industry, and put forward suggestions for the development of this industry.</span></p>

Research on the Training Method of Clinical Thinking in Human Anatomy Teaching

<p><span lang="EN-US">Human anatomy is a science to study the normal human body shape and structure. It is an important basic medical course, and closely related to various medical disciplines, especially to clinical medicine. Under the concept of comprehensive quality education, anatomy teachers should not only impart theoretical knowledge and professional skills, but also pay attention to the cultivation of students’ clinical thinking ability, so as to lay a solid foundation for students’ subsequent professional study and clinical practice. This paper focuses on the training of clinical thinking in human anatomy teaching.</span></p>