Spherulosis of the Breast

1999 ◽  
Vol 123 (7) ◽  
pp. 626-630 ◽  
Author(s):  
Eoghan E. Mooney ◽  
Naila Kayani ◽  
Fattaneh A. Tavassoli
Keyword(s):  
Basement Membrane ◽  
Invasive Carcinoma ◽  
Armed Forces ◽  
Membrane Material ◽  
Material Deposition ◽  
Immunohistochemical Profile

Abstract Objective.—Collagenous spherulosis of the breast is an uncommon localized pattern of basement membrane material deposition that may be mistaken for atypical proliferations or carcinoma. This report describes 9 cases in which the predominant or exclusive appearance of the spherules was basophilic instead of eosinophilic. Design.—The files of all cases of collagenous spherulosis diagnosed at the Armed Forces Institute of Pathology were reviewed to ascertain the frequency of diagnosis. Results.—Spherulosis with a predominantly basophilic pattern had a histochemical and immunohistochemical profile similar to collagenous spherulosis and was associated with more collagenous-appearing forms in 7 of 9 cases. Review of 81 cases showed that collagenous spherulosis was correctly diagnosed in 15% of referrals and was mistaken for intraductal or invasive carcinoma in 11% of cases. Conclusions.—Mucinous and collagenous patterns appear to be related forms of spherulosis. They are underrecognized by pathologists and maybe mistaken for atypia or malignancy.

scholarly journals Age-related changes in glomerular volume and hydroxyproline content in rat and human.

1992 ◽  
Vol 2 (12) ◽  
pp. 1716-1725
Author(s):  
P Cortes ◽  
X Zhao ◽  
F Dumler ◽  
B C Tilley ◽  
J Atherton
Keyword(s):  
Basement Membrane ◽  
Computer Assisted ◽  
Membrane Material ◽  
Hydroxyproline Content ◽  
Outer Cortex ◽  
Material Content ◽  
Glomerular Volume ◽  
Material Deposition ◽  
Age Related ◽  
Glomerular Size

Total 4-hydroxyproline content and volume were measured in the same sample of microdissected glomeruli obtained fro rat and human outer or inner cortex. Glomerular volume was determined by computer-assisted image analysis, and 4-hydroxyproline was measured by a highly sensitive gas-liquid chromatographic method. Results were expressed as weight of basement membrane material by comparison with the amount of 4-hydroxyproline in purified basement membrane/mesangial matrix preparations. Microanalyses were possible in samples containing as few as eight human glomeruli. Rat glomerular size increased sevenfold between 5 wk and 2 yr of age, with volume being consistently 36 to 45% greater in inner than in outer cortex glomeruli. Basement membrane material content per glomerulus markedly increased with age (12-fold); however, when expressed per unit volume, this change was greatly reduced (2-fold). Expressed per volume, inner and outer cortex glomerular content of basement membrane material was always similar, regardless of age. Therefore, a greater glomerular size, in itself, does not accelerate the rate of basement membrane material deposition. Glomerular size distributions (measured by skewness and kurtosis) did not change, indicating that, although glomerular volume increases with age, aging does not appear to cause the emergence of distinct glomerular populations within an age group. Basement membrane material accumulation is probably a generalized change. Human glomeruli increased sevenfold in size from infancy to adulthood and then declined during senescence. Contrary to that in the rat, glomerular basement membrane material content appeared to closely follow size changes, thus, varying little from infancy to senescence if expressed per unit of glomerular volume.

Ultrastructural evidence of transplacental transport of immunoglobulin G in bitches

Reproduction ◽  
2000 ◽  
pp. 315-326 ◽  
Author(s):  
MH Stoffel ◽  
AE Friess ◽  
SH Hartmann
Keyword(s):  
Mammary Gland ◽  
Basement Membrane ◽  
Immunoglobulin G ◽  
Passive Immunity ◽  
Morphological Evidence ◽  
Membrane Material ◽  
Ultrastructural Evidence ◽  
Cytotrophoblast Cells ◽  
Fetal Vessels

In dogs, passive immunity is conferred to fetuses and neonates by the transfer of maternal immunoglobulin G through the placenta during the last trimester of pregnancy and via the mammary gland after parturition, respectively. However, morphological evidence of transplacental transport is still lacking. The aim of the present study was to localize maternal immunoglobulin G in the labyrinthine zone and in the haemophagous zone of the canine placenta by means of immunohistochemistry and immunocytochemistry. In the labyrinthine zone, immunoglobulin G was detected in all the layers of the materno-fetal barrier including the fetal capillaries. Immunoreactivity was particularly prominent in maternal basement membrane material as well as in the syncytiotrophoblast. However, this evidence of transplacental transport of immunoglobulin G originated from a limited number of unevenly distributed maternal vessels only. In the cytotrophoblast of the haemophagous zone, immunoglobulin G was localized to phagolysosomes at various stages but was never detected within fetal vessels. The results indicate that maternal immunoglobulin G is degraded in cytotrophoblast cells of the hemophagous zone and, therefore, that transplacental transport is restricted to a subpopulation of maternal vessels in the labyrinthine zone.

Non-visible haematuria in a military setting

2018 ◽  
Vol 104 (3) ◽  
pp. 177-182
Author(s):  
D O’Brien ◽  
K Houlberg
Keyword(s):  
Basement Membrane ◽  
Immunoglobulin A ◽  
Armed Forces ◽  
Common Finding ◽  
Immunoglobulin A Nephropathy ◽  
Hereditary Nephritis ◽  
Military Recruits ◽  
Thin Basement Membrane Disease ◽  
Medical Examinations

AbstractAsymptomatic non-visible haematuria is a common finding at routine military medical examinations. This article briefly reviews the possible causes, which include malignancy, structural causes, exertion haematuria, hereditary nephritis, thin basement membrane disease (TBMD), immunoglobulin A nephropathy (IgAN), tuberculosis (TB) and schistosomiasis. This paper discusses how these conditions may affect potential military recruits as well as currently serving members of the Armed Forces, and offers a general approach to the management of a patient with non-visible haematuria.

Massive myoepithelial proliferation (myoepitheliosis) with lumpy deposits of basement membrane material closely associated with apocrine adenosis and ductal carcinomain situof the breast

2011 ◽  
Vol 61 (10) ◽  
pp. 615-617
Author(s):  
Tomonori Kawasaki ◽  
Toshio Oyama ◽  
Hiroshi Nakagomi ◽  
Kazushige Furuya ◽  
Tetsuo Kondo ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Membrane Material

Basement Membrane Material and Tigroid Background in a Fine Needle Aspirate of Clear Cell Adenocarcinoma of the Cervix

2000 ◽  
Vol 44 (2) ◽  
pp. 251-254 ◽  
Author(s):  
Mitsuyoshi Hirokawa ◽  
Michio Shimizu ◽  
Etsuko Nakamura ◽  
Takuo Kanahara ◽  
Hideaki Yamauchi ◽  
...  
Keyword(s):  
Basement Membrane ◽  
Clear Cell ◽  
Clear Cell Adenocarcinoma ◽  
Membrane Material ◽  
Fine Needle Aspirate ◽  
Fine Needle

scholarly journals TRANSFER OF AN AUTOIMMUNE NEPHROSIS IN THE RAT BY MEANS OF LYMPH NODE CELLS

1962 ◽  
Vol 115 (2) ◽  
pp. 421-438 ◽  
Author(s):  
Evelyn V. Hess ◽  
Charles T. Ashworth ◽  
Morris Ziff
Keyword(s):  
Lymph Node ◽  
Basement Membrane ◽  
Tubular Epithelium ◽  
Membrane Material ◽  
Spleen Cells ◽  
Histological Changes ◽  
Immunological Mechanism ◽  
Neonatal Injection ◽  
Lymph Node Cells ◽  
Freund's Adjuvant

An autoimmune nephrosis produced in rats by repeated injections of kidney extract with Freund's adjuvant has been transferred by means of lymph node cells to recipient animals rendered tolerant by neonatal injection with spleen cells from prospective donors. Transfer of the disease was manifested in the recipients by the development of proteinuria, hypoalbuminemia, hypercholesterolemia,and histological changes. The latter consisted of glomerular epithelial swelling, increase in basement membrane material and the presence of protein droplets in the glomerular and tubular epithelium. Appropriate control experiments were negative. Attempts to transfer with serum were unsuccessful. The transfer described is believed to provide evidence for an immunological mechanism for kidney and adjuvant induced nephrosis in the rat.

Chondrogenesis in chick embryo somites grafted with adjacent and heterologous tissues

Development ◽  
1972 ◽  
Vol 27 (1) ◽  
pp. 229-234
Author(s):  
M. J. O'Hare
Keyword(s):  
Chick Embryo ◽  
Basement Membrane ◽  
Membrane Material ◽  
Grafting Technique ◽  
Cartilage Differentiation ◽  
Sulphated Glycosaminoglycans ◽  
Embryonic Ectoderm

A variety of heterologous tissues have been tested for the ability to promote cartilage differentiation in isolated chick-embryo somites, using a modified chorioallantoic grafting technique. Of the 12 tissues tested only 3- and 4-day embryonic ectoderm promoted somite chondrogenesis in somites that fail to chondrify when grafted in isolation. This activity of ectoderm was evident in grafts of somites isolated with adjacent ectoderm, and in grafts of somites recombined with ectoderm derived from several sources. Four-day embryonic limbbud ectoderm, including the apical ridge, was capable of promoting somite chondrogenesis, but to no greater extent than dorsal trunk ectoderm of the same age. It is suggested that the ability of embryonic ectoderm to promote cartilage differentiation in isolated somites is associated with its ability to synthesize basement membrane material (sulphated glycosaminoglycans and collagen), in association with adjacent somite mesoderm.

A histochemical study of sulphated glycosaminoglycans associated with the somites of the chick embryo

Development ◽  
1973 ◽  
Vol 29 (1) ◽  
pp. 197-208
Author(s):  
M. J. O'Hare
Keyword(s):  
Chick Embryo ◽  
Basement Membrane ◽  
Alcian Blue ◽  
Chondroitin Sulphate ◽  
Matrix Material ◽  
Paraxial Mesoderm ◽  
Membrane Material ◽  
Sulphated Glycosaminoglycans ◽  
Sulphated Glycosaminoglycan ◽  
Chondroitin Sulphate A

A histochemical analysis has been made of sulphated glycosaminoglycans (mucopolysaccharides) associated with chick embryo somites before and after the onset of overt cartilage differentiation. The sulphated glycosaminoglycans were distinguished and resolved into different types by the use of alcian blue at low pH and alcian blue ‘critical electrolyte concentration’ staining combined with hyaluronidase digestion. The newly formed somites are bounded on their dorsal, ventral, and medial surfaces by basement membrane material as they are delimited from the unsegmented paraxial mesoderm Such epithelial basement membrane material, which was first detected in association with the epiblast/mesoderm boundary in the stage-4 embryo, was found to contain a major chondroitin sulphate A/C fraction and a minor chondroitin sulphate B fraction. The notochord sheath contained similar sulphated glycosaminoglycans. Sulphated glycosaminoglycans were first detected between cells of the somite ‘core’ at stage 14 and were subsequently seen to accumulate around the cells of the developing sclerotome and later around cells of the dermatome; the myotome was devoid of such material at these stages (stage 14–20). These pre-cartilaginous sulphated glycosaminoglycans were also of the chondroitin sulphate A/C plus chondroitin sulphate B types. In contrast, the matrix material of newly forming vertebral cartilage, which was first seen in the anterior region of stage 21 embryos, was distinguished by its lack of a hyaluronidase-resistant sulphated glycosaminoglycan component, and therefore presumably contained only chondroitin sulphates A/C. Much later in development (after stage 33) small amounts of sulphated glycosaminoglycan with the staining properties of keratan sulphate were found in the perichordal and subperichondrial regions of the vertebral cartilage.

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