Lymphoepithelioma-like Carcinoma of the Ovary: A Case Report and Review of the Literature

2007 ◽  
Vol 131 (11) ◽  
pp. 1715-1718 ◽  
Author(s):  
Sun Lee ◽  
Sang Yoon Park ◽  
Eun Kyung Hong ◽  
Jae Yoon Ro
Keyword(s):  
Lymph Nodes ◽  
Female Genital Tract ◽  
Undifferentiated Carcinoma ◽  
Ca 125 ◽  
Epithelioid Cells ◽  
Supraclavicular Lymph Nodes ◽  
Node Metastases ◽  
The Right ◽  
Carcinoma Of The Ovary ◽  
Female Genital

Abstract Lymphoepithelioma-like carcinoma is an undifferentiated carcinoma morphologically characterized by sheets of pleomorphic epithelioid cells with an intense lymphoid infiltrate. A 51-year-old woman presenting with low abdominal pain was found to have a right ovarian mass and enlarged pelvic, left para-aortic, and left supraclavicular lymph nodes. Based on a clinical diagnosis of right ovarian carcinoma with lymph node metastases, she received 9 cycles of chemotherapy, resulting in a reduction of her ovarian tumor, disappearance of the enlarged pelvic and para-aortic lymph nodes, and normalization of serum CA 125 level. The residual mass was removed surgically. The histology of the multinodular tumor resembled that of lymphoepithelioma of the nasopharynx and was observed in the right ovary. However, there was no viable tumor in either supraclavicular or para-aortic lymph nodes. Seven months after surgery, the patient has no evidence of disease. Lymphoepithelioma-like carcinoma appears to be rare in the female genital tract.

Synchronous primary endometrial and ovarian cancer with three different histologic patterns: A case report

2003 ◽  
Vol 13 (5) ◽  
pp. 678-682 ◽  
Author(s):  
Y.-S. Ree ◽  
S.-H. Cho ◽  
S.-R. Kim ◽  
S.-H. Cho ◽  
K.-T. Kim ◽  
...  
Keyword(s):  
Clear Cell ◽  
Clear Cell Carcinoma ◽  
Female Genital Tract ◽  
Figo Stage ◽  
Primary Cancer ◽  
Metastatic Lesions ◽  
Synchronous Cancers ◽  
Stage Ia ◽  
The Right ◽  
Female Genital

Synchronous cancers involving both endometrium and ovary in the female genital tract is a well-recognized phenomenon. However, most of them are metastatic lesions arising from one organ and simultaneous primary cancer occurring in both organs is relatively rare. We report a case with dual primary cancer occurring in both ovaries and endometrium with three different histologies. Recently, a 46-year-old women presented with vaginal bleeding was found to have FIGO stage IC clear cell carcinoma of the left ovary, stage IA borderline mucinous cystadoma of the right ovary, and stage IB endometrial carcinoma of endometrioid type. We present this case with a brief review of references.

scholarly journals Rotura Uterina às 18 Semanas de Gravidez no Contexto de Útero Malformado

2016 ◽  
Vol 29 (10) ◽  
pp. 667
Author(s):  
Emídio Vale-Fernandes ◽  
Neusa Teixeira ◽  
Alexandra Cadilhe ◽  
Maria José Rocha
Keyword(s):  
Uterine Rupture ◽  
Female Genital Tract ◽  
Obstetric Outcomes ◽  
Placenta Increta ◽  
Abnormal Placentation ◽  
History Of ◽  
Uterine Malformations ◽  
The Right ◽  
Congenital Uterine Anomaly ◽  
Female Genital

Birth defects of the female genital tract are relatively common and often asymptomatic. Despite the pregnancy outcome can be favorable, adverse obstetric outcomes are described in women with uterine malformations. The authors report the case of an obstetric emergency which enhances the possibility of a very adverse and rare outcome of uterine rupture in a left hemi-cavity of a bicornuate uterus away from the term, at 18 weeks of pregnancy, in a pregnant woman with history of caesarean in the right hemi-cavity and with placenta increta. A malformed uterus with a primitive type cavity has lower distensibility of the wall with the progression of the pregnancy and facilitates the development of abnormal placentation forms, increasing the risk of uterine rupture in the first and second trimesters. The knowledge of the existence of a congenital uterine anomaly in the preconceptional period is of primary importance.

scholarly journals Giant adrenal germ cell tumour in a 59-year-old woman

2016 ◽  
Vol 10 (5-6) ◽  
pp. 201
Author(s):  
Lei Chen ◽  
Lu Fang ◽  
Zhiqi Liu ◽  
Dexin Yu ◽  
Daming Wang ◽  
...  
Keyword(s):  
Pleural Effusion ◽  
Lymph Nodes ◽  
Germ Cell ◽  
Germ Cell Tumour ◽  
Malignant Tumour ◽  
Large Mass ◽  
Needle Aspiration ◽  
Cell Tumour ◽  
Supraclavicular Lymph Nodes ◽  
The Right

Adrenal germ cell tumour is very rare. We report a case of a 59-year-old woman who presented with right flank discomfort. The laboratory examinations were normal and the chest computed tomography (CT) showed right pleural effusion. The abdominal CT scan revealed a large mass on the right adrenal gland. The patient underwent an adrenalectomy. Histopathologic examination and immunohistochemical findings were consistent with mixed germ cell tumour. Three months later following the operation, the patient was admitted to our hospital again with chest tightness and shortness of breath. The chest CT showed right pleural effusion recurrence and enlargement of mediastinal lymph nodes and right hilar lymph nodes. The patient had right supraclavicular lymphadenectasis on physical examination. Fine needle aspiration cytology from the supraclavicular lymph nodes showed groups of malignant tumour cells. The patient died within 6 months postoperatively. In this case, the lymph node pathway played an important role in the metastatic procedure.

scholarly journals Primary Fallopian Tube Carcinoma: A Case Report and Literature Review

2017 ◽  
Vol 5 (3) ◽  
pp. 344-348 ◽  
Author(s):  
Meral Rexhepi ◽  
Elizabeta Trajkovska ◽  
Hysni Ismaili ◽  
Florin Besimi ◽  
Nagip Rufati
Keyword(s):  
Fallopian Tube ◽  
Female Genital Tract ◽  
Lower Abdominal Pain ◽  
Ca 125 ◽  
Histopathological Diagnosis ◽  
Fallopian Tube Carcinoma ◽  
Rare Tumour ◽  
Initial Surgery ◽  
Primary Fallopian Tube Carcinoma ◽  
The Right

BACKGROUND: Primary fallopian tube carcinoma (PFTC) is a rare tumour of the female genital tract with an incidence of 0.1-1.8% of all genital malignancies, and it is very difficult to diagnose preoperatively, because of its non-specific symptomatology. In most cases, it is an intraoperative finding or a histopathological diagnosis. It is a tumour that histologically and clinically resembles epithelial ovarian cancer.CASE PRESENTATION: We are reporting a case of a 62-year-old, postmenopausal women with primary fallopian tube carcinoma of the right fallopian tube in stage IA. The patient has lower abdominal pain, watery vaginal discharge and repeated episodes of bleeding from the vagina. The clinical and radiological findings suggested a right adnexal tumour with elevated CA-125 levels. Total abdominal hysterectomy, bilateral salpingo-oophorectomy, omentectomy and peritoneal washing were performed. Pathologic confirmation of primary serous cystadenocarcinoma of the right fallopian tube was made. Peritoneal washings were negative for malignancy. FIGO stage was considered as IA, and the patient received no courses of chemotherapy and postoperative radiation because she refused it. Ten months after initial surgery, the patient is alive and in good condition.CONCLUSION: Cytoreduction surgery followed by adequate cycles of chemotherapy is an important strategy to improve patients’ prognosis.

scholarly journals CA-125:Use as a tumor marker with mixed mesodermal tumors of the female genital tract

Cancer ◽  
1986 ◽  
Vol 58 (12) ◽  
pp. 2625-2627 ◽  
Author(s):  
William A. Peters ◽  
Charles M. Bagley ◽  
Michael R. Smith
Keyword(s):  
Tumor Marker ◽  
Genital Tract ◽  
Female Genital Tract ◽  
Ca 125 ◽  
Female Genital

scholarly journals Parotid gland adenocarcinoma in a cow: case report

2018 ◽  
Vol 70 (3) ◽  
pp. 758-766
Author(s):  
P.J.B. Queiroz ◽  
T.D. Queiroz ◽  
P.L. Magalhães ◽  
N.C. Borges ◽  
D.B. Martins ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Lymph Nodes ◽  
Polyclonal Antibodies ◽  
Malignant Neoplasm ◽  
Needle Aspiration ◽  
Undifferentiated Carcinoma ◽  
Submandibular Region ◽  
Parotid Region ◽  
Needle Aspiration Cytology ◽  
The Right

ABSTRACT A 9-year-old Girolando dairy cow, weighing 400kg, with a history of increased volume in the right parotid region, which extended to the submandibular region, was assisted. Fine needle aspiration cytology was performed, and the cytological findings were consistent with malignant neoplasm of epithelial origin (carcinoma). Because of the unfavorable prognosis, the animal was euthanized and submitted to an anatomopathological examination. Samples of the increased parotid and affected lymph nodes were collected for histopathological evaluation. The microscopic changes were accentuated features of anaplasia, moderate cell proliferation, atypical mitotic figures, and necrosis. Stroma ranged from delicate to scirrhous, and the tumor boundaries were not distinct. These findings substantiated the preliminary histomorphological diagnosis of undifferentiated carcinoma with metastasis in lymph nodes. Immunohistochemical tests were performed with anti-CK Pan (clone AE1AE3), anti-CK HMW (clone 34βE12), anti-CK19 (clone RCK108), anti-vimentin (clone V9), anti-S100 (polyclonal), and anti-androgen (polyclonal) antibodies. The immunophenotype favored the diagnosis of salivary gland adenocarcinoma. Despite the rareness in cattle, salivary gland adenocarcinoma should be considered in the differential diagnosis of diseases that occur with increased volume in the head, lymphadenopathy, drooling, dysphagia, and progressive weight loss.

scholarly journals Metastatic Adenocarcinoma of the Right Supraclavicular Lymph Nodes from Primary Ovarian Cancer: A Rare Presentation

2019 ◽  
Vol 35 (3) ◽  
pp. 190-193
Author(s):  
Azmaniza Baharudin ◽  
Habibah Abdul Hamid ◽  
Ngan Kah Wai ◽  
Ruwaida Abdul Rahim ◽  
Zainab Yahaya
Keyword(s):  
Ovarian Cancer ◽  
Lymph Nodes ◽  
Metastatic Adenocarcinoma ◽  
Rare Presentation ◽  
Primary Ovarian Cancer ◽  
Supraclavicular Lymph Nodes ◽  
The Right

scholarly journals Breast metastasis from pelvic high-grade serous adenocarcinoma: a report of two cases

2020 ◽  
Vol 6 (1) ◽  
Author(s):  
Yurina Harada ◽  
Makoto Kubo ◽  
Masaya Kai ◽  
Mai Yamada ◽  
Karen Zaguirre ◽  
...  
Keyword(s):  
Genital Tract ◽  
Abdominal Cavity ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
High Grade ◽  
Peritoneal Cancer ◽  
Cancer Tumor ◽  
Stage Ivb ◽  
The Right ◽  
Female Genital

Abstract Background Metastatic tumors to the breast reportedly account for 0.5% to 2.0% of all malignant breast diseases. Such metastatic tumors must be differentiated from primary breast cancer. Additionally, few reports have described metastases of gynecological cancers to the breast. We herein report two cases of metastasis of pelvic high-grade serous adenocarcinoma to the breast. Case presentation The first patient was a 57-year-old woman with a transverse colon obstruction. Colostomy was performed, but the cause of the obstruction was unknown. We found scattered white nodules disseminated throughout the abdominal cavity and intestinal surface. Follow-up contrast-enhanced computed tomography (CT) showed an enhanced nodule outside the right mammary gland. Core needle biopsy (CNB) of the right breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. We diagnosed the patient’s condition as breast and lymph node metastasis of a high-grade serous carcinoma of the female genital tract. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. The second patient was a 71-year-old woman with a medical history of low anterior resection for rectal cancer at age 49, partial right thyroidectomy for follicular thyroid cancer at age 53, and left lower lung metastasis at age 57. Periodic follow-up CT showed peritoneal dissemination, cancerous peritonitis, and pericardial effusion, and the patient was considered to have a cancer of unknown primary origin. Contrast-enhanced CT showed an enhanced nodule in the left mammary gland with many enhanced nodules and peritoneal thickening in the abdominal cavity. CNB of the left breast mass was conducted, and immunohistochemical staining of the mass suggested a high-grade serous carcinoma of female genital tract origin. After chemotherapy for stage IVB peritoneal cancer, tumor reduction surgery was performed. Conclusions We experienced two rare cases of intramammary metastasis of high-grade serous carcinoma of female genital tract origin. CNB was useful for confirming the histological diagnosis of these cancers that had originated from other organs. A correct diagnosis of such breast tumors is important to ensure quick and appropriate treatment.

scholarly journals Immunohistochemistry: A diagnostic aid in differentiating primary epithelial ovarian tumors and tumors metastatic to the ovary

2013 ◽  
Vol 02 (04) ◽  
pp. 254-258 ◽  
Author(s):  
Divya Kriplani ◽  
Mandakini M. Patel
Keyword(s):  
Wilms Tumor ◽  
Female Genital Tract ◽  
Serous Carcinoma ◽  
Cancer Antigen 125 ◽  
Significant Development ◽  
Epithelial Tumors ◽  
Ovarian Pathology ◽  
Carcinoma Of The Ovary ◽  
Serous Tumors ◽  
Female Genital

Abstract Introduction: Among cancers of the female genital tract, the incidence of ovarian cancer ranks below only carcinoma of the cervix and the endometrium. Recent years have witnessed significant development in the use of immunohistochemistry in diagnostic ovarian pathology. Materials and Methods: We received 95 specimens and biopsies of primary ovarian neoplasms and neoplasms metastatic to the ovary in a period of 2 years. Of these 30 cases were of the primary surface epithelial neoplasms and seven of metastatic tumors. Discussion: The most common tumors metastasizing to the ovary originate from the gastrointestinal tract followed by the endometrium. We used a panel of six markers including cytokeratin-7 (CK7), CK20, carcinoembryonic antigen (CEA), cancer antigen 125 (CA125), estrogen receptor (ER) and Wilms’ tumor 1 (WT1) to help classify various surface epithelial tumors as well as to differentiate them from tumors metastatic to the ovary. Conclusion: CK7 is the most helpful marker to differentiate primary ovarian carcinoma from metastatic colorectal carcinoma of the ovary. Nearly, 96% of ovarian adenocarcinomas were positive for CK7 in contrast to metastatic colorectal, which showed only 25% positivity. We also found that CK7, CK20 and CEA are useful markers to differentiate primary serous tumors from primary mucinous tumors; however, these are less helpful in differentiating ovarian mucinous adenocarcinomas from colorectal adenocarcinomas metastasizing to the ovaries. WT1 helps in typing primary surface epithelial tumors of the ovary and is also significant in determining whether a serous carcinoma within the ovary is primary or metastatic.

Giant adrenal germ cell tumor in a 59-year-old woman: A case report and review of the literature

2015 ◽  
Vol 10 (1-2) ◽  
Author(s):  
Lei Chen
Keyword(s):  
Computed Tomography ◽  
Pleural Effusion ◽  
Lymph Nodes ◽  
Germ Cell ◽  
Germ Cell Tumor ◽  
Large Mass ◽  
Needle Aspiration ◽  
Cell Tumor ◽  
Supraclavicular Lymph Nodes ◽  
The Right

Adrenal germ cell tumor is very rare. We report a case of a 59-year-old woman who presented with right flank discomfort. The laboratory examinations were basically normal. Chest computed tomography showed right pleural effusion. Abdominal computed tomography scan revealed a large mass on the right adrenal gland. The patient underwent adrenalectomy. Histopathologic examination and immunohistochemical findings were consistent with mixed germ cell tumor. Three months later following operation, the patient was admitted to our hospital again with chest tightness and shortness of breath. The chest CT showed right pleural effusion recurrence and enlargement of mediastinal lymph nodes and right hilar lymph nodes. The patient had the right supraclavicular lymphadenectasis on physical examination. Fine needle aspiration cytology from the supraclavicular lymph nodes showed groups of malignant tumor cells. The patient died within 6 months postoperatively. In this case, the lymph node pathway plays an important role in the metastatic procedure.

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