Parotid gland adenocarcinoma in a cow: case report

ABSTRACT A 9-year-old Girolando dairy cow, weighing 400kg, with a history of increased volume in the right parotid region, which extended to the submandibular region, was assisted. Fine needle aspiration cytology was performed, and the cytological findings were consistent with malignant neoplasm of epithelial origin (carcinoma). Because of the unfavorable prognosis, the animal was euthanized and submitted to an anatomopathological examination. Samples of the increased parotid and affected lymph nodes were collected for histopathological evaluation. The microscopic changes were accentuated features of anaplasia, moderate cell proliferation, atypical mitotic figures, and necrosis. Stroma ranged from delicate to scirrhous, and the tumor boundaries were not distinct. These findings substantiated the preliminary histomorphological diagnosis of undifferentiated carcinoma with metastasis in lymph nodes. Immunohistochemical tests were performed with anti-CK Pan (clone AE1AE3), anti-CK HMW (clone 34βE12), anti-CK19 (clone RCK108), anti-vimentin (clone V9), anti-S100 (polyclonal), and anti-androgen (polyclonal) antibodies. The immunophenotype favored the diagnosis of salivary gland adenocarcinoma. Despite the rareness in cattle, salivary gland adenocarcinoma should be considered in the differential diagnosis of diseases that occur with increased volume in the head, lymphadenopathy, drooling, dysphagia, and progressive weight loss.

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Fine-Needle Aspiration Cytology of Cellular Basaloid Neoplasms of the Salivary Gland

Archives of Pathology & Laboratory Medicine ◽

10.5858/arpa.2019-0327-ra ◽

2019 ◽

Vol 143 (11) ◽

pp. 1338-1345 ◽

Cited By ~ 1

Author(s):

Richard L. Cantley

Keyword(s):

Salivary Gland ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Malignant Neoplasm ◽

Needle Aspiration ◽

Malignant Neoplasms ◽

Aspiration Cytology ◽

Fine Needle ◽

Stromal Component ◽

Needle Aspiration Cytology

Context.— Cellular basaloid neoplasms of the salivary gland represent a diverse group of benign and malignant neoplasms with significant cytomorphologic overlap on fine-needle aspiration cytology. All are marked by the presence of monotonous and usually bland basaloid epithelium. Distinction between basaloid neoplasms on fine-needle aspiration cytology is based on the presence or absence of additional features, including a second cell population (eg, myoepithelial cells), an acellular stromal component, and/or cytologic atypia within the basaloid epithelium. This review highlights the cytomorphologic features of the most common cellular basaloid neoplasms of the salivary gland, with an emphasis on classification and subclassification within the Milan System. Objective.— To provide a comprehensive review of the cytologic features of basaloid epithelial neoplasms of the salivary gland, with an emphasis on classification within the Milan System for Reporting Salivary Gland Cytopathology. Data Sources.— Peer-reviewed literature, recent textbooks, and personal experiences of the author. Conclusions.— Some basaloid neoplasms, in particular pleomorphic adenomas and adenoid cystic carcinomas, may have characteristic findings on fine-needle aspiration that allow for definitive diagnosis. In other cases, however, fine-needle aspiration can confirm a neoplastic basaloid process, but specific classification of a benign or malignant neoplasm cannot be rendered. The Milan System for Reporting Salivary Gland Cytopathology acknowledges this difficulty, and recommends benign or malignant classification only when definitive diagnostic features of a specific neoplasm are present. For indeterminate cases, the subcategorization of salivary neoplasm of uncertain malignant potential is recommended.

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Primary Mucoepidermoid Carcinoma Arising from Ectopic Salivary Tissue within an Intraparotid Lymph Node

Case Reports in Otolaryngology ◽

10.1155/2015/879137 ◽

2015 ◽

Vol 2015 ◽

pp. 1-3 ◽

Cited By ~ 1

Author(s):

Fatemah Faras ◽

Fawaz Abo-Alhassan ◽

Jassem Bastaki ◽

Mutlaq K. Al-Sihan

Keyword(s):

Salivary Gland ◽

Lymph Node ◽

Lymph Nodes ◽

Needle Aspiration ◽

Low Grade ◽

Warthin Tumor ◽

Diagnostic Pitfall ◽

Deep Margin ◽

Intermediate Cells ◽

The Right

Ectopic salivary tissue is commonly found in intraparotid and periparotid lymph nodes. Warthin tumor is the most common tumor arising in ectopic salivary gland tissue and in intraparotid lymph nodes. Although rare, neoplastic transformation of the ectopic salivary tissues is conceivable and other types of salivary gland neoplasms arising in intraparotid lymph nodes have been reported. Herein we report a rare case of a 32-year-old Kuwaiti male who presented with a mass in the right parotid gland. A preoperative fine needle aspiration suggested Warthin tumor. The patient underwent a superficial parotidectomy. The specimen showed a mass within the parotid parenchyma abutting the deep margin. Hematoxylin and Eosin stained sections of the lesion showed solid islands and cysts composed of epidermoid cells, mucus cells, and intermixed smaller “intermediate” cells within an intraparotid lymph node. The tumor was seen infiltrating the parotid parenchyma at the deep margin. Metastasis from distant sites was ruled out clinically, and the diagnosis rendered was MEC, low-grade, arising from ectopic salivary tissue in an intraparotid lymph node. Such cases are extremely rare and the presence of malignancies within lymph nodes may pose a diagnostic pitfall, which can affect patient management.

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Submandibular lipoma in elderly female in mid western Nepal: A Case Report

Janaki Medical College Journal of Medical Science ◽

10.3126/jmcjms.v4i2.17076 ◽

2017 ◽

Vol 4 (2) ◽

pp. 46-49

Author(s):

Bishow Tulachan ◽

Buddha Nath Borgohain

Keyword(s):

Needle Aspiration ◽

The Body ◽

Rare Entity ◽

Medical Sciences ◽

Diagnostic Dilemma ◽

Submandibular Region ◽

Medical College ◽

Needle Aspiration Cytology ◽

The Right ◽

Rule Out

Background and Objectives: The submandibular lipomas are relatively rare entity. The reported age of the patients were from birth to 84 years old, and average being 55.7 years. These are mainly asymptomatic and mostly cause aesthetic concerns. Deep lipomas, especially in the head and neck, are not commonly reported. To our knowledge there’s not even a single publication regarding the lipoma in the submandibular region in our mid western region as well as in our country.Presentation of case: A 72 years old female presented with complaints of painless progressive neck swelling in the right submandibular region for about 2 years. Clinically, it was thought to be submandibular gland neoplasm/ lymphadenopathy. Ultrasonography (USG) and fine-needle aspiration cytology (FNAC) were done. It was negative for malignancy. She underwent excision of the mass under general anesthesia without postoperative complications. The histopathology confirmed it to be lipoma. Discussion: Lipoma is a common benign mesenchymal tumour that is found almost anywhere in the body. However, a large lipoma is relatively rare in the submandibular region. On clinical doubt, one can rely on USG / MRI (magnetic resonance imaging) and FNAC to rule out diagnostic dilemma. The treatment of choice is simply excision. Conclusion: It’s a rare entity and may be the first report of a lipoma in the submandibular region in an elderly people. One should rule out its possibility while going through the submandibular region diseases.Janaki Medical College Journal of Medical Sciences (2016) Vol. 4 (2): 46-49

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Thyroglobulin measurements in fine-needle aspiration cytology of lymph nodes in patients after thyroidectomy because of differentiated thyroid cancer

Endocrine Abstracts ◽

10.1530/endoabs.35.p1116 ◽

2014 ◽

Author(s):

Emilia Musial ◽

Jacek Galczynski ◽

Elwira Bakula-Zalewska ◽

Marek Dedecjus

Keyword(s):

Thyroid Cancer ◽

Lymph Nodes ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Differentiated Thyroid Cancer ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology

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Small lymphocytic lymphoma as a random finding in lymph nodes with metastasis from an undifferentiated carcinoma of the submandibular salivary gland

10.26226/morressier.596dfd59d462b80292387cc3 ◽

2017 ◽

Author(s):

Maria Kilmpasani

Keyword(s):

Salivary Gland ◽

Lymph Nodes ◽

Undifferentiated Carcinoma ◽

Submandibular Salivary Gland ◽

Small Lymphocytic Lymphoma

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Correlation of FNAC and histopathology in diagnosis of salivary gland lesions

Journal of Pathology of Nepal ◽

10.3126/jpn.v4i8.11593 ◽

2014 ◽

Vol 4 (8) ◽

pp. 654-657 ◽

Cited By ~ 2

Author(s):

S Koirala ◽

G Sayami ◽

AD Pant

Keyword(s):

Salivary Gland ◽

Preoperative Diagnosis ◽

Needle Aspiration ◽

University Teaching ◽

Malignant Neoplasms ◽

Histopathological Diagnosis ◽

Institute Of Medicine ◽

Needle Aspiration Cytology ◽

Sensitivity Specificity ◽

Diagnostic Pitfalls

Background: Value of fine needle aspiration cytology in preoperative diagnosis of salivary gland lumps has been established in various studies. This study aims to calculate sensitivity, specificity accuracy of FNAC, correlate FNAC findings with histopathology and find out reasons for common diagnostic pitfalls in FNAC.Materials and methods: This study was performed in 67 patients that presented with salivary gland lumps at Department of pathology, Tribhuvan University Teaching Hospital, Institute of medicine, Kathmandu, Nepal from January 2009 to June 2010. FNAC was performed and was correlated with histopathological diagnosis to judge the sensitivity, specificity and accuracy of FNAC.Results: Out of 36 cases there was cyto-histological correlation in 28 cases. Pleomorphic adenoma was the most frequent lesion in this study. Parotid gland was the most common site affected by salivary gland lesions. The sensitivity, specificity and accuracy for non-neoplastic lesions was 100%, 89.28%, 91.67%, for benign neoplasms was 100%, 86.95%, 91.67% and for malignant neoplasms was 57.14%, 100%, 83.33% respectively.Conclusion: FNAC is a useful tool in preoperative diagnosis of salivary gland lesions and can be crucial for the management of the patient. Aspiration and reporting of salivary gland lesions demands a competent pathologist who considers all the possible diagnostic pitfalls in mind.DOI: http://dx.doi.org/10.3126/jpn.v4i8.11593 Journal of Pathology of Nepal; Vol.4,No. 8 (2014) 654-657

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Accuracy of fine‐needle aspiration cytology in the diagnosis of salivary gland masses according to the Milan reporting system and to an in‐house system

Diagnostic Cytopathology ◽

10.1002/dc.24682 ◽

2020 ◽

Author(s):

Soumaya Rammeh ◽

Emna Romdhane ◽

Meriem Ksentini ◽

Linda Belhajkacem ◽

Nadia Znaidi ◽

...

Keyword(s):

Salivary Gland ◽

Fine Needle Aspiration ◽

Fine Needle Aspiration Cytology ◽

Reporting System ◽

Needle Aspiration ◽

Aspiration Cytology ◽

Fine Needle ◽

Needle Aspiration Cytology

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Diagnostic Algorithm for Metastatic Lymph Nodes of Differentiated Thyroid Carcinoma

Cancers ◽

10.3390/cancers13061338 ◽

2021 ◽

Vol 13 (6) ◽

pp. 1338

Author(s):

Sae Rom Chung ◽

Jung Hwan Baek ◽

Young Jun Choi ◽

Tae-Yon Sung ◽

Dong Eun Song ◽

...

Keyword(s):

Lymph Nodes ◽

Diagnostic Algorithm ◽

Needle Aspiration ◽

Differentiated Thyroid Carcinoma ◽

Ultrasound Guided ◽

Aspiration Cytology ◽

Fine Needle ◽

Malignancy Rate ◽

Needle Aspiration Cytology ◽

Ultrasound Features

We aimed to evaluate appropriate strategies for interpreting fine-needle aspiration cytology (FNAC) and thyroglobulin concentrations obtained through aspiration (FNA-Tg) results based on the sonographic features of lymph nodes (LNs). Consecutive patients who underwent ultrasound-guided FNAC and FNA-Tg for metastatic LNs from differentiated thyroid carcinomas (DTCs) from January 2014 to December 2018 were reviewed retrospectively. LNs were categorized sonographically as suspicious, indeterminate, or benign. The optimal FNA-Tg cutoff for metastatic LNs was evaluated preoperatively, after lobectomy, and after total thyroidectomy. The diagnostic performances of FNA-Tg, FNAC, and their combination were analyzed based on the sonographic features of LNs. The malignancy rates of LNs were analyzed based on the sonographic features, FNAC, and FNA-Tg results. Of the 1543 LNs analyzed, 528 were benign, whereas 1015 were malignant. FNA-Tg increased the sensitivity and accuracy of FNAC for LNs. The malignancy rate of LNs found to be malignant by FNAC or elevated FNA-Tg ranged from 82% to 100%, regardless of the sonographic features. The malignancy rate of LNs with indeterminate or benign FNAC findings and low FNA-Tg were stratified according to their sonographic features. We propose a diagnostic algorithm, based on combined FNAC, FNA-Tg, and ultrasound features of LNs, for diagnosing metastatic LNs of DTCs.

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