Basaloid Follicular Hamartoma

2010 ◽  
Vol 134 (8) ◽  
pp. 1215-1219 ◽  
Author(s):  
Omie Mills ◽  
L. Brannon Thomas
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Basal Cell ◽  
Benign Lesion ◽  
Treatment Strategies ◽  
Correct Identification ◽  
Benign Lesions ◽  
Experimental Therapies ◽  
Periodic Monitoring

Abstract Basaloid follicular hamartoma is a benign lesion of important consideration because it can be mistaken both clinically and histologically for basal cell carcinoma. The formation of basaloid follicular hamartoma has been linked to a mutation in the patched gene, which is part of the same pathway implicated in nevoid basal cell carcinoma syndrome. While these hamartomas are considered benign lesions, malignant growths have been reported to arise within them, which raises the question, “Is basaloid follicular hamartoma a premalignant lesion?” Correct identification allows for periodic monitoring for malignant transformation, while sparing patients unnecessary surgery. Treatment strategies, including experimental therapies, are reviewed.

Differentiation among basal cell carcinoma, benign lesions, and normal skin using electric impedance

2003 ◽  
Vol 50 (8) ◽  
pp. 1020-1025 ◽  
Author(s):  
D.G. Beetner ◽  
S. Kapoor ◽  
S. Manjunath ◽  
Xiangyang Zhou ◽  
W.V. Stoecker
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Normal Skin ◽  
Electric Impedance ◽  
Benign Lesions

scholarly journals Trichoepithelioma of thigh. Third reported case

2015 ◽  
Vol 1 (3) ◽  
pp. 187
Author(s):  
Sandesh Deolekar ◽  
Nisha Mandhane ◽  
Sharique Ansari ◽  
Tanveer Shaikh ◽  
Sangram Karandikar
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Hair Follicle ◽  
Malignant Transformation ◽  
Basal Cell ◽  
Benign Tumor ◽  
Wide Excision ◽  
Basal Cells ◽  
Close Resemblance ◽  
Adnexal Tumors

<p class="abstract"><span lang="EN-US">Trichoepithelioma a small benign tumor derived from basal cells in the hair follicle. A trichoepithelioma can undergo malignant transformation into the basal cell carcinoma. The recognition of trichoepithelioma is important because of its close resemblance to basal cell carcinoma and other skin adnexal tumors, both clinically and histopathologically. Here we present case of 40 year old male presenting with painless swelling in right thigh. Wide excision of swelling was done and sent for histopathology which showed the swelling to be trichoepithelioma.</span></p>

scholarly journals Discrimination of basal cell carcinoma from benign lesions based on extraction of ulcer features in polarized-light dermoscopy images

2012 ◽  
Vol 18 (4) ◽  
pp. 471-475 ◽  
Author(s):  
Serkan Kefel ◽  
Pelin Guvenc ◽  
Robert LeAnder ◽  
Sherea M. Stricklin ◽  
William V. Stoecker
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Polarized Light ◽  
Benign Lesions

scholarly journals Patched Knockout Mouse Models of Basal Cell Carcinoma

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Frauke Nitzki ◽  
Marco Becker ◽  
Anke Frommhold ◽  
Walter Schulz-Schaeffer ◽  
Heidi Hahn
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Mouse Models ◽  
Basal Cell ◽  
Knockout Mouse ◽  
Treatment Strategies ◽  
Human Tumor ◽  
Current Treatment ◽  
Preclinical Research ◽  
Potential Use

Basal cell carcinoma (BCC) is the most common human tumor. Mutations in the hedgehog (HH) receptor Patched (PTCH) are the main cause of BCC. Due to their high and increasing incidence, BCC are becoming all the more important for the health care system. Adequate animal models are required for the improvement of current treatment strategies. A good model should reflect the situation in humans (i.e., BCC initiation due toPtchmutations on an immunocompetent background) and should allow for (i) BCC induction at a defined time point, (ii) analysis of defined BCC stages, and (iii) induction of BCC in 100% of animals. In addition, it should be easy to handle. Here, we compare several currently existing conventional and conditionalPtchknockout mouse models for BCC and their potential use in preclinical research. In addition, we provide new data using conditionalPtchflox/floxmice and theK5-Cre-ERT+/−driver.

Malignant Transformation of Nonhealing Ulcer—Basal Cell Carcinoma

2021 ◽  
Vol 70 ◽  
pp. 565.e7-565.e10
Author(s):  
Michael Nicoara ◽  
Kevin Bain ◽  
Ronak Patel ◽  
Omkaar Jaikaran ◽  
Anil Hingorani ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Basal Cell

scholarly journals Basal cell carcinoma stroma as a mimicker of lymphatic invasion: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091960
Author(s):  
Marco Caruana ◽  
Meggie Morand ◽  
Annie Belisle ◽  
Mélissa Nantel-Battista
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Lymphatic Vessels ◽  
Lymphatic Invasion ◽  
Correct Identification ◽  
Therapeutic Implications ◽  
Superficial Dermis ◽  
The Right ◽  
Cell Lining

Basal cell carcinoma metastases are rare. We report a case of an 83 year-old male with recurrent cutaneous infiltrative basal cell carcinoma on the right vertex with tumor aggregates of infiltrative basal cell carcinoma in the lymphatic vessels of the superficial dermis strongly suspected on pathology slide evaluation during Mohs micrographic surgery. D2-40 immunohistochemical stain allows the detection of lymphatic invasion by highlighting endothelial cells. Further histologic review and D2-40 stains performed on the paraffin-embedded sections did not reveal an endothelial cell lining in favor of lymphatic invasion. What was identified as lymphatic invasion was the result of a peculiar basal cell carcinoma stroma. Correct identification of basal cell carcinoma stroma as a mimicker of lymphatic invasion would prevent potentially invasive investigation as well as associated costs. This is of great importance as the prognostic and therapeutic implications can be of significant value for the patient.

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