scholarly journals Basal cell carcinoma stroma as a mimicker of lymphatic invasion: A case report

2020 ◽  
Vol 8 ◽  
pp. 2050313X2091960
Author(s):  
Marco Caruana ◽  
Meggie Morand ◽  
Annie Belisle ◽  
Mélissa Nantel-Battista
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Lymphatic Vessels ◽  
Lymphatic Invasion ◽  
Correct Identification ◽  
Therapeutic Implications ◽  
Superficial Dermis ◽  
The Right ◽  
Cell Lining

Basal cell carcinoma metastases are rare. We report a case of an 83 year-old male with recurrent cutaneous infiltrative basal cell carcinoma on the right vertex with tumor aggregates of infiltrative basal cell carcinoma in the lymphatic vessels of the superficial dermis strongly suspected on pathology slide evaluation during Mohs micrographic surgery. D2-40 immunohistochemical stain allows the detection of lymphatic invasion by highlighting endothelial cells. Further histologic review and D2-40 stains performed on the paraffin-embedded sections did not reveal an endothelial cell lining in favor of lymphatic invasion. What was identified as lymphatic invasion was the result of a peculiar basal cell carcinoma stroma. Correct identification of basal cell carcinoma stroma as a mimicker of lymphatic invasion would prevent potentially invasive investigation as well as associated costs. This is of great importance as the prognostic and therapeutic implications can be of significant value for the patient.

Basal Cell Carcinoma on the Right Hallux

2003 ◽  
Vol 30 (3) ◽  
pp. 250-251 ◽  
Author(s):  
Kiyomi Matsushita ◽  
Akira Kawada ◽  
Yoshinori Aragane ◽  
Tadashi Tezuka
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
The Right

scholarly journals Basal Cell Carcinoma with Disseminated Bone Metastization: An Unusual Outcome of the Most Common Malignancy

2021 ◽  
Vol 79 (3) ◽  
pp. 261-264
Author(s):  
Luísa Rolim ◽  
Bruno M. Fernandes ◽  
Carolina Carvalho ◽  
António Silva ◽  
Joana Calvão ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Survival Rates ◽  
Palliative Radiotherapy ◽  
High Morbidity ◽  
Common Skin ◽  
Metastatic Basal Cell Carcinoma ◽  
Low Incidence ◽  
The Right

Basal cell carcinoma is the most common skin cancer, with a very low incidence of metastases, associated with high morbidity and mortality. The morpheaform clinical variant is uncommon, presenting an aggressive growth pattern. Early diagnosis and new targeted therapies for metastatic disease are important to improve survival rates. We present the case of a 29-year-old patient with morpheaform basal cell carcinoma in the right genian region. Due to local recurrences, he underwent surgery and adjuvant radiotherapy. For extensive metastatic bone involvement, the patient started vismodegib and, later, pembrolizumab, and also performed palliative radiotherapy. Despite several lines of systemic therapy, the disease progressed, and the patient died after 8 years of follow-up. This case shows how crucial it is to identify risk factors for metastatic basal cell carcinoma and highlights the need to improve target therapies and tailor them to the patient’s biological profile.

scholarly journals Pigmented Paraaxillary Located "Complex" Basal Cell Carcinoma Imitating clinically irritated Melanocytic Lesion - Succesfull Surgical Approach in Bulgarian Patient

2017 ◽  
Vol 5 (4) ◽  
pp. 497-500
Author(s):  
Cristiana Voicu ◽  
Mara Mihai ◽  
Mihai Lupu ◽  
James W. Patterson ◽  
Nely Koleva ◽  
...  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Histopathological Examination ◽  
Surgical Excision ◽  
Melanocytic Lesion ◽  
Complete Surgical Excision ◽  
Axillary Region ◽  
The Right ◽  
Clinical Subtype

BACKGROUND: Basal cell carcinoma (BCC) is the most frequently encountered neoplasm worldwide. While nodular BCC is the most frequent clinical subtype, other forms of BCC, such as superficial, cystic, morpheiform, infiltrative, and pigmented may also be encountered.CASE PRESENTATION: We present the case of a 67-year-old male with a relatively well-defined infiltrative, pigmented plaque with multiple colours and peripheral growth situated in the right axillary region. The histopathologic examination performed after complete surgical excision of the tumour revealed a complex pigmented BCC with macronodular, fibroepithelioma-like, cystic, focally infiltrative and basosquamous features.CONCLUSION: Uncommon locations of BCCs in sun-protected areas such as the axillary region require a higher degree of suspicion for diagnosis. The complex histology of the presented case, including subtypes with differing biologic attributes, emphasises the importance of histopathological examination in the diagnosis and therapeutic management of BCC.

scholarly journals Spontaneous Regression of Annular Basal Cell Carcinoma: A Case Report

2019 ◽  
Vol 11 (2) ◽  
pp. 145-149
Author(s):  
Usho Go ◽  
Kazunori Miyata ◽  
Masaru Fujita ◽  
Takashi Ohide ◽  
Tsuyoshi Mitsuishi
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Spontaneous Regression ◽  
Histopathological Examination ◽  
Sweat Glands ◽  
Temporal Region ◽  
Japanese Male ◽  
Old Japanese ◽  
The Right

We herein present a case of annular basal cell carcinoma (BCC) with spontaneous regression on the right temporal region of a 56-year-old Japanese male. Histopathological examination revealed that the central section had no tumor cells. The sweat glands, follicles, and other cutaneous appendages were also absent. This pattern of spontaneous regression is quite uncommon, and understanding the histopathology may be important for future approaches to BCC.

scholarly journals A A Rare Case of a Metastatic Basal Cell Carcinoma

2020 ◽  
Vol 2 (5) ◽  
Author(s):  
Hiba Chaudhry ◽  
Dimitrios Doumpiotis
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Incidence Rate ◽  
Basal Cell ◽  
Literature Search ◽  
Primary Tumour ◽  
Sun Exposure ◽  
Metastatic Basal Cell Carcinoma ◽  
Radiation Genetic ◽  
The Right

Background: Basal cell carcinomas are malignant slow-growing neoplasms of the epidermal layer of the skin. They are the most common form of skin cancer, accounting for 80% of non-melanoma skin cancers. Metastasis is rare with an incidence rate of 0.0028 to 0.55%. We report a case of an 83 year old male presenting with basal cell carcinoma (BCC) of the right cheek. The tumour was completely excised with close margins. The patient was closely monitored clinically and on follow-up, a mass in the region of the right parotid was identified. Excision of the tail of the right parotid identified a tumour with similar subtype to the primary tumour excised from the cheek confirming diagnosis of metastatic BCC. Methods: A literature search was carried out inclusive of the terms identify existing data and guidelines to determine best evidence based practice. Discussion: Literature search identified aetiology of BCCs and methods of diagnosis and treatment. The search also highlighted an incidence rate of 0.0028 to 0.55% and complications associated with metastasis. The patient underwent a course of radiotherapy as surgery in this case was contraindicated due to history of excision of the parotid tail. Risk factors for developing BCCs include intermittent sun exposure, ionising radiation, genetic predisposition and immunosuppression. Metastases occurs via the lymphatic system or haematogenously. Surgery is the main form of treatment and aims to be curative.

scholarly journals Locally advanced basal cell carcinoma of the auricle and parotid region: A case report

2021 ◽  
Vol 68 (2) ◽  
pp. 94-98
Author(s):  
Srdjan Milanovic ◽  
Suzana Stojanovic-Rundic ◽  
Nikola Milosevic ◽  
Branko Dozic ◽  
Marko Dozic
Keyword(s):  
Case Report ◽  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Multidisciplinary Approach ◽  
Locally Advanced ◽  
Parotid Region ◽  
Basal Cell Carcinomas ◽  
The Right ◽  
Advanced Basal Cell Carcinoma

Skin cancers are the most common malignant tumors in general. The most significant risk factor is exposure to UV radiation. They mainly occur in the head and neck region, and the majority of about 80% are basal cell carcinomas. Surgery is standard treatment of uncomplicated basal cell carcinomas, but a multidisciplinary approach is necessary in advanced cases. The case report refers to a patient with locally advanced recurrent basal cell carcinoma with primary tumor localization in the right auricle and parotid region in 2012 when primary surgery was performed. Due to the local recurrence, amputation of the right auricle and trepanation of the mastoid process was done in November 2018, and after that, radiation therapy of a recurrent tumor in the area of the trepanation cavity was applied. In the course of follow-up so far, there is good local control, without signs of toxicity. The case report points to the importance of a multidisciplinary approach and the role of radiotherapy in the treatment and control of advanced basal cell carcinoma of this region.

scholarly journals A Case of Infiltrative Basal Cell Carcinoma Sustaining the Necessity of the Thorough Clinicopathological Correlation

2017 ◽  
Vol 2 (1) ◽  
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Clinicopathological Correlation ◽  
The Right

Dermatology is almost the only field in medicine where the diagnosis is “lying on the surface”, and very often the only tools we need to make the right diagnosis are our own eyes and the tips of our fingers. Fortunately, in most cases it works well.

scholarly journals Giant Basal Cell Carcinoma – a Case Report

2018 ◽  
Vol 10 (3) ◽  
pp. 83-89
Author(s):  
Igor Kapetanović ◽  
Vesna Reljić ◽  
Martina Bosić ◽  
Svetlana Popadić
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Slow Growth ◽  
Rare Type ◽  
Basal Cell Carcinomas ◽  
The Right ◽  
Electron Radiotherapy ◽  
Giant Basal Cell Carcinoma ◽  
Cutaneous Cancer

Abstract Basal cell carcinoma is the most common form of cutaneous cancer. In majority of cases it is locally invasive with slow growth, ranging in size from a couple of milimeters to a couple of centimeters and located primarily on sun-exposed regions. Giant basal cell carcinoma, defined as a tumor that is larger than 5 cm in diameter, is a very rare type of cutaneous malignancy accounting for 0.5-1% of all basal cell carcinomas. We present a case of a 74-year-old man with a 17 x 14 cm giant basal cell carcinoma in the right supraclavicular region. Detailed history revealed that the lesion had started as a papule 15 years before presentation. Despite its growth, the lesion was neglected until admission. Histological examination of skin lesion confirmed superficial and focally infiltrative types of basal cell carcinoma. Electron radiotherapy was administered with 54 Gy total dose delivered in 20 daily fractions which resulted in healing of lesions and adequate response. Thus, definitive radiotherapy can be just as effective as excision when the criteria are met.

Basal cell carcinoma with signet ring cell morphology accumulating the ubiquitinated cytokeratin 5/6

2021 ◽  
Vol 14 (4) ◽  
pp. e241993
Author(s):  
Ayako Watanabe ◽  
Naoshige Iida ◽  
Katsuhiko Enomoto
Keyword(s):  
Basal Cell Carcinoma ◽  
Cell Carcinoma ◽  
Basal Cell ◽  
Cell Morphology ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Cytokeratin 5 ◽  
Ubiquitin Proteasome ◽  
Ring Cell ◽  
The Right

Basal cell carcinoma (BCC) showing signet ring (SR) cell morphology is a very rare variant of BCC. Here, we report BCC with SR cell morphology developed in the right cheek skin of a 79-year-old man. Histopathologic examination showed irregularly shaped islands of basaloid cells with characteristic peripheral palisading. Inside of the cancer islands, many tumour cells showed an enlarged fine granular cytoplasm with the peripherally compressed nuclei, being similar to the SR cell. Immunohistochemical examination revealed dense accumulation of cytokeratin (CK) 5/6 and a faint signal of 34βE12 in SR cells. The reported myoepithelial markers were not detected. Interestingly, ubiquitin, a component of the ubiquitin–proteasome protein degradation system, was co-localised in the SR cells. These suggest, for the first time, that accumulation of the undegraded CK5/6 with ubiquitination results in the SR cell morphology. Our report showed that the aberrant keratin turnover is associated with the SR cell BCC.

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