Primary Bone Tumors: Epidemiologic Comparison of 9200 Patients Treated at Beijing Ji Shui Tan Hospital, Beijing, China, With 10 165 Patients at Mayo Clinic, Rochester, Minnesota

Context Although primary bone tumors are extremely rare, the literature suggests that there are variations in the epidemiologic characteristics in different populations. The most frequently cited epidemiologic characteristics of primary bone tumors are derived from a large US series (Mayo Clinic), with no comparable study thus far performed in China. Objective To identify any potential epidemiologic differences between Chinese patients and a US series of patients. Design We performed a comparison study between 9200 patients treated at Beijing Ji Shui Tan Hospital (JST) and 10 165 patients treated at Mayo Clinic (MC), Rochester Minnesota. Detailed epidemiologic features were analyzed. Results We found that giant cell tumor and osteosarcoma have significantly higher incidences in the JST than the MC patients (P < .001). However, JST patients had a significantly lower incidence of Ewing sarcoma, chordoma, fibrosarcoma, myeloma, and malignant lymphoma (P < .001). For most benign and malignant bone tumors, the Chinese cohort had a more distinct male predominance than the US cohort. Malignant bone tumors had a monomodal age distribution in the JST patient group, with a bimodal age distribution in the MC cohort. Also, there were was a predilection for tumors of the femur and tibia among the JST patients (P < .001). Conclusions Our data confirm that epidemiologic variations of primary bone tumors exist in different populations. Factors that may contribute to these observed differences are proposed and discussed.

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Scintigraphy with 99m Tc-Phosphonate and 67Gallium in Patients Suspected of Primary Bone Tumors

Nuklearmedizin ◽

10.1055/s-0037-1620567 ◽

1982 ◽

Vol 21 (04) ◽

pp. 136-139 ◽

Cited By ~ 2

Author(s):

C.-J. Edeling

Keyword(s):

Soft Tissue ◽

Bone Scintigraphy ◽

Primary Tumor ◽

Bone Tumors ◽

Whole Body ◽

Skeletal Metastases ◽

Malignant Bone Tumors ◽

67Ga Scintigraphy ◽

Primary Bone Tumors ◽

Primary Bone

Whole-body scintigraphy with both 99mTc-phosphonate and 67Ga was performed on 92 patients suspected of primary bone tumors. In 46 patients with primary malignant bone tumors, scintigraphy with 99mTc-phosphonate disclosed the primary tumor in 44 cases and skeletal metastases in 11, and 67Ga scintigraphy detected the primary tumor in 43 cases, skeletal metastases in 6 cases and soft-tissue metastases in 8 cases. In 25 patients with secondary malignant bone tumors, bone scintigraphy visualized a single lesion in 10 cases and several lesions in 15 cases, and 67Ga scintigraphy detected the primary tumor in 17 cases, skeletal metastases in 17 cases and soft-tissue metastases in 9 cases. In 21 patients with benign bone disease positive uptake of 99mTc-phosphonate was recognized in 19 cases and uptake of 67Ga in 17 cases. It is concluded that bone scintigraphy should be used in patients suspected of primary bone tumors. If malignancy is suspected, 67Ga scintigraphy should be performed in addition.

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Comparison between Benign and Malignant Primary Bone Tumors-A Histopathological Study of 119 Cases

Al-Mustansiriyah Journal of Science ◽

10.23851/mjs.v29i2.182 ◽

2018 ◽

Vol 29 (2) ◽

pp. 74

Author(s):

Farah Falah Hasan ◽

Haider Lateef Mohammed

Keyword(s):

Bone Tumors ◽

Benign Tumors ◽

Histopathological Study ◽

Malignant Bone Tumors ◽

Female Ratio ◽

Primary Bone Tumors ◽

Benign Bone Tumors ◽

Common Location ◽

Primary Bone ◽

The Mean

This is a prospective study done at Al wasity teaching hospital for reconstructive surgeries in Bagdad in a period from November 2014 to April 2017, using a Total of 119 samples of primary bone tumors which were diagnosed both histopathologically and radiologically. The main objectives of this study was to make a comparison between benign and malignant bone tumors. Immunohistochemical staining was done to confirm the diagnosis of primary malignant bone tumors and the proliferative index of them were carefully evaluated. Out of 119 samples of primary bone tumors used in this study ,100 (84%) were benign and borderline(osteoclastoma) and 19(16%) were malignant, the mean age for benign tumors was lower than the mean age for primary malignant one and both frequently present in the 2nd decade of life, male to female ratio for benign bone tumors was 3\2 and 8.5\1 for primary malignant one, femure was the most common location for benign bone tumors while tibia was the most common bone affected by primary malignant bone tumors. the study also showed that the most common benign bone tumors were osteochondromas(67%) and most common primary malignant bone tumors were osteosarcomas(52.63%),thus this study rise a conclusion that in general, primary bone tumors were mainly benign, occurred predominantly in the second decade of life with a male preponderance

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Proximal Femur Versus Acetabular Extra-articular Resection of the Hip Joint for Primary Malignant Bone Tumors : A Retrospective Comparative Review of 33 Cases

10.21203/rs.3.rs-917462/v1 ◽

2021 ◽

Author(s):

Victor Housset ◽

Philippe Anract ◽

Antoine Babinet ◽

Guillaume Auberger ◽

David Biau

Keyword(s):

Hip Joint ◽

Proximal Femur ◽

Bone Tumors ◽

Malignant Bone Tumors ◽

Primary Bone Tumors ◽

Comparative Review ◽

Primary Bone ◽

The Mean ◽

Cumulative Probabilities

Abstract Introduction Extra-articular resection (EAR) of the hip joint is prone to significant complications and morbidity. Thus, this study evaluates the cumulative incidences and main reasons of reoperation following EAR of primary bone tumors of the hip to determine whether the outcomes are different between EAR of the pelvis and that of the proximal femur. Patients and methods Thirty-three patients presented with a PMBT of the proximal femur or pelvis were included in this study. Among all PMBTs, 58% originated from the pelvis and 42% were from the proximal femur. Twenty patients had chondrosarcomas (61%), 10 had osteosarcomas (30%), and 3 had sarcomas of another histological subtype (9%). Results The mean follow-up was of 76 months (range: 24–220 months). The cumulative probabilities of revision for any reason was 52% (95% confidence interval [CI]: 30%–70%) five years after surgery. The five-year cumulative probabilities of revision were 13% (95% CI: 4%–27%), 24% (95% CI: 10%–42%) and 34% (95% CI: 14%–56%) for mechanical, infectious and tumoral reasons, respectively. The five-year cumulative probabilities of revision for any reason were 78% (95% CI: 37%–94%) and 14% (95% CI: 2%–38%) for the pelvis and proximal femur, respectively ( p = 0.004). Posterior column preservation was significantly associated with more mechanical complications even after adjusting for the resection site ( p = 0.043). Conclusion Half of patients undergoing EAR of the hip joint for PMBT of the proximal femur or acetabulum will require another operation. EAR of the pelvis is associated with significantly worse outcome than EAR of the proximal femur.

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Malignant bone tumors in Pediatrics. Five year experience in a pediatric referral center

Revista de la Facultad de Medicina ◽

10.15446/revfacmed.v64n3.50475 ◽

2016 ◽

Vol 64 (3) ◽

pp. 403

Author(s):

Gisela Barros ◽

Angela Maria Trujillo ◽

Lina Jaramillo ◽

Francy Helena Ortiz ◽

Agustin Dario Contreras

Keyword(s):

Neoadjuvant Chemotherapy ◽

Bone Tumors ◽

Ewing’S Sarcoma ◽

Surgical Intervention ◽

Ewing's Sarcoma ◽

Survival Rates ◽

Pediatric Hospital ◽

Malignant Bone Tumors ◽

Primary Bone Tumors ◽

Primary Bone

Background: Osteosarcoma (OS) and Ewing’s Sarcoma (ES) are the two most common malignant bone tumors in children. A retrospective review of the records of children diagnosed in a pediatric hospital over a five year period (2008-2013) was performed.Objective: To present the experiences acquired during the treatment of these types of tumors and to compare the results obtained with those reported in the literature.Methodology: The database of the Oncology and Pathology Service of Fundación Hospital de la Misericordia (HOMI) was reviewed to identify patients with primary bone tumors referred for histopathology analysis.Results: 22 patients were diagnosed with OS, with a mean age of 11.9 years. 96% of cases were located in the lower extremities. All patients received neoadjuvant chemotherapy and 86% underwent surgical treatment; 13% survived. 15 patients were diagnosed with ES, with a mean age of 12.4 years. 67% of cases were located in flat bones, 53% of patients had metastasis when diagnosed, and all received neoadjuvant chemotherapy. 40% of patients received surgical intervention and 20% received radiotherapy. Survival at the completion of the reseearch was 33%.Conclusions: Cure and survival rates are lower than those reported in the literature despite efforts to improve treatments.Keywords: Osteosarcoma; Ewing’s Sarcoma; Disease Progression; Recurrence; Neoplasm Metastasis (MeSH).

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Computed tomography analysis of primary bone tumors : the significance in the evaluation of destructive lesionsof pelvic bone

Journal of the Korean Radiological Society ◽

10.3348/jkrs.1988.24.4.648 ◽

1988 ◽

Vol 24 (4) ◽

pp. 648

Author(s):

J S Suh ◽

E J Lee ◽

C Y Park

Keyword(s):

Computed Tomography ◽

Bone Tumors ◽

Pelvic Bone ◽

Primary Bone Tumors ◽

Primary Bone ◽

Tomography Analysis

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CRYOSURGERY IN THE TREATMENT OF PATIENTS WITH BONE TUMORS

Problems in oncology ◽

10.37469/0507-3758-2019-65-2-165-171 ◽

2019 ◽

Vol 65 (2) ◽

pp. 165-171

Author(s):

Aleksey Belyaev ◽

Georgiy Prokhorov ◽

Anna Arkhitskaya

Keyword(s):

Liquid Nitrogen ◽

Bone Tumors ◽

Cryogenic Treatment ◽

Long Term Results ◽

Bone Lesions ◽

Giant Cell Tumors ◽

Primary Bone Tumors ◽

Circulation Circuit ◽

Recent Emergence ◽

Primary Bone

A review of the literature shows that surgical procedures will remain the standard treatment for primary bone tumors. Analysis of studies on the assessment of long-term results shows that additional double cryogenic treatment of the curettage cavity can improve the treatment outcomes of patients with giant cell tumors, dysplastic diseases and some forms of malignant lesions. The traditional execution of the procedure is associated with the open installation of liquid nitrogen in the bone cavity, which requires special skills in handling aggressive refrigerant from the staff and does not exclude complications. In case of multiple metastatic bone lesions, surgical treatment is not indicated. The recent emergence in clinical practice of new equipment with a closed liquid nitrogen circulation circuit inside cryoprobes resumes interest in cryoabla-tion of bone tumor lesions using modern minimally invasive puncture cryotechnology and expanding indications for its use in patients with severe comorbidities.

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