Protective effect of catalpol on isoproterenol-induced myocardial injury in Wistar rats

Objectives: This study was undertaken to investigate the possible protective effect of aqueous extract of Phyllanthus fraternus (AEPF) leaves against cyclophosphamide (CP) induced myocardial toxicity in rats.Methods: Wistar rats were given CP single intraperitoneally injection (200 mg/kg) on day 1 of the experiment and two doses of AEPF (200 mg/kg and 400 mg/kg) p.o. daily for 10 days. Cardiac biomarker enzymes such as creatinine kinase (CK), CK isoenzyme MB, lactate dehydrogenase, alkaline phosphatase, alanine transaminase, and aspartate transaminase were determined. Histopathological examinations of the hearts were done.Results: CP treated groups exhibited significantly increased in cardiac biomarker enzymes. Treatment with AEPF prevented the elevation of these enzymes. Potential protective effect was also seen in histopathological examination of the heart characterized by decreased myocardium cell damages in AEPF treatment group.Conclusion: The study showed the protective role of AEPF against CP-induced myocardial injury. The possible role of antioxidant activity is anticipated.

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Beneficial Protective Effect of Troxerutin on Nickel-Induced Renal Dysfunction in Wistar Rats

Journal of Environmental Pathology Toxicology and Oncology ◽

10.1615/jenvironpatholtoxicoloncol.2017025087 ◽

2018 ◽

Vol 37 (1) ◽

pp. 1-14 ◽

Cited By ~ 2

Author(s):

Perumal Elangovan ◽

Ramalingam Ramakrishnan ◽

Kasinathan Amudha ◽

Abdulkadhar Mohamed Jalaludeen ◽

Gunasekaran Karuna Sagaran ◽

...

Keyword(s):

Protective Effect ◽

Renal Dysfunction ◽

Wistar Rats

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Total Intravenous Anesthesia for Myocardial Protection and Preconditioning

Journal of Cardiac Critical Care TSS ◽

10.1055/s-0041-1723932 ◽

2021 ◽

Author(s):

Minati Choudhury

Keyword(s):

Protective Effect ◽

Surgical Procedure ◽

Myocardial Protection ◽

Myocardial Injury ◽

Volatile Anesthetic ◽

Organ Protection ◽

Intravenous Anesthesia ◽

Intravenous Anesthetic ◽

Anesthetic Agents ◽

Anesthetic Preconditioning

AbstractPerioperative myocardial injury is common after any major surgical procedure even with best possible anesthesia and surgical management. Organ preservation during surgical procedure prevents morbidity and mortality. The effect of ischemic preconditioning on myocardial as well as other organ protection is well known. A variety of other agents also shown to have preconditioning thus protective effect on myocardium during anesthesia and surgery. The beneficial effect of volatile anesthetic preconditioning is well studied. However, the effect of intravenous anesthetic agents on this context is still way to go. This review is an attempt to look into the latest available research regarding the preconditioning and myocardial protective effect of intravenous anesthetic agents.

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