scholarly journals Protective effect of vitamin C against ivermectin induced nephrotoxicity in different age groups of male wistar rats: bio-histopathological study

2021 ◽  
Author(s):  
Shereen E. Tawfeek ◽  
Ayat M. Domouky ◽  
Reham H. Abdel-Kareem
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Wistar Rats ◽  
Age Groups ◽  
Histopathological Study ◽  
Male Wistar Rats

scholarly journals Protective effect of vitamin C on chronic carbamazepine-induced reproductive toxicity in male wistar rats

2020 ◽  
Vol 7 ◽  
pp. 269-276 ◽  
Author(s):  
Ganiu Jimoh Akorede ◽  
Suleiman Folorusho Ambali ◽  
Mikai’l Garba Hudu ◽  
Aisha Omobolanle Olatunji ◽  
Muftau Shittu ◽  
...  
Keyword(s):  
Vitamin C ◽  
Protective Effect ◽  
Wistar Rats ◽  
Reproductive Toxicity ◽  
Male Wistar Rats

Protective effect of chrysin on carbon tetrachloride (CCl4)—induced tissue injury in male Wistar rats

2011 ◽  
Vol 27 (10) ◽  
pp. 923-933 ◽  
Author(s):  
Kalaiselvi Velayutham Anand ◽  
Ramalingam Anandhi ◽  
Murugesan Pakkiyaraj ◽  
Pitchairaj Geraldine
Keyword(s):  
Carbon Tetrachloride ◽  
Vitamin C ◽  
Protective Effect ◽  
Wistar Rats ◽  
Tissue Injury ◽  
Protective Action ◽  
Intraperitoneal Administration ◽  
Serum Levels ◽  
Male Wistar Rats ◽  
The Mean

Chrysin, a natural flavonoid has been reported to possess potent anti-inflammatory, anti-cancer and antioxidation properties. In the present study, we aimed to evaluate the putative protective effect of chrysin, an isoflavone, on carbon tetrachloride (CCl4)-induced toxicity in male Wistar rats. Intraperitoneal administration of CCl4 (2 ml/kg) to rats for 4 days resulted in significantly elevated ( p < 0.05) serum levels of glutamic oxaloacetic transaminase (SGOT), glutamic pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lactate dehydrogenase (LDH), when compared to normal rats. In addition, the tissues (liver, kidney and brain) and haemolysate samples showed considerable increase in levels ( p < 0.05) of malondialdehyde (MDA) and lowered levels ( p < 0.05) of reduced glutathione (GSH), vitamin C and E when compared to values in normal rats. Quantitative analysis of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (Gpx) exhibited lower activities of these antioxidant enzymes in the tissues and haemolysate of CCl4-administered rats. The protective action of chrysin on CCl4-induced rat was demonstrated with SGPT, SGOT, ALP and LDH resuming to near normal levels, while the mean levels of GSH and of vitamin C and E were elevated, the mean activities of CAT, SOD and Gpx were enhanced and the mean level of MDA was lowered in the tissue and haemolysate samples when compared to the CCl4-exposed untreated rats. The expression of the iNOS gene appeared to be up-regulated in the liver and kidney samples of CCl4-exposed untreated rats, whereas in CCl4-exposed chrysin-treated rats, the mRNA transcript levels of iNOS approximated normal levels. These results strongly suggest that chrysin is able to prevent the oxidative damage induced by CCl4 in the liver, brain, kidney and haemolysate of male Wistar rats.

Effect of vitamin A and vitamin C on attenuation of ivermectin-induced toxicity in male Wistar rats

2018 ◽  
Vol 25 (29) ◽  
pp. 29408-29417 ◽  
Author(s):  
Fatemeh Sadat Hosseini Omshi ◽  
Roghayeh Abbasalipourkabir ◽  
Maliheh Abbasalipourkabir ◽  
Sedigheh Nabyan ◽  
Alireza Bashiri ◽  
...  
Keyword(s):  
Vitamin A ◽  
Vitamin C ◽  
Wistar Rats ◽  
Male Wistar Rats

scholarly journals Effectiveness of Vitamin C and Vitamin E Antioxidant Combination on Caspase-3 Expression in Wistar White Rat Pulmonum Contusion

2020 ◽  
Vol 3 (1) ◽  
pp. 31-44
Author(s):  
Bermansyah ◽  
Gama Satria ◽  
Ahmad Umar
Keyword(s):  
Cell Death ◽  
Vitamin E ◽  
Vitamin C ◽  
Wistar Rats ◽  
Caspase 3 ◽  
Cell Function ◽  
Pulmonary Contusion ◽  
Tnf Α ◽  
Male Wistar Rats

Introduction.Pulmonary contusions can cause a progressive inflammatory response. Activation of TNF-α cytokines and reactive oxygen species (ROS) can cause pulmonary cell death. Antioxidants can have the potential to neutralize ROS. The purpose of this study is to determine the effectiveness of antioxidant administration in maintaining pulmonary cell function in wistar rats that have been induced to experience pulmonary contusions through caspase-3 levels. Methods.This study was an in vivo experimental study conducted on thirty male wistar rats and divided into five groups (n = 6): control, pulmonary contusion + asthaxanthine 5 mg/kgBW, pulmonary contusion + vitamin C and E 50 mg/kgBW, pulmonary contusion + vitamin C and E 100 mg/kgBW, pulmonary contusion + vitamin C and E 200 mg/kgBW. The value of Caspase-3 is evaluated by the IHC. All data analyzes used SPSS 18. Results. Low doses of antioxidants have the potential to reduce pulmonary cell death in wistar rats induced by pulmonary contusions.Conclussion. Vitamin C and E effective to reduce polmonary cell death in pulmonary contusion.Keywords: antioxidants, vitamin C, vitamin E, pulmonary contusions animal model, apoptosis, caspase-3

scholarly journals Vitamin C decreases the obesogenic and hyperglycemic effect of invert sugar in prediabetic rats

2017 ◽  
Vol 30 (1) ◽  
pp. 23-32 ◽  
Author(s):  
Patrícia MOLZ ◽  
Alana Nunes RAEL ◽  
Maiara de Queiroz FISCHER ◽  
Luana Beatriz LIMBERGER ◽  
Daniel PRÁ ◽  
...  
Keyword(s):  
Vitamin C ◽  
Glucose Tolerance ◽  
Body Mass ◽  
Wistar Rats ◽  
Area Under The Curve ◽  
Tolerance Test ◽  
Invert Sugar ◽  
Future Studies ◽  
Fasting Glycemia ◽  
Male Wistar Rats

ABSTRACT Objective: To evaluate whether vitamin C can help to prevent obesity and hyperglycemia in Wistar rats treated with excess invert sugar to induce prediabetes. Methods: One hundred-day-old Male Wistar rats with a mean weight of 336.58±23.43g were randomly assigned to the following groups: (1) control, receiving water (C); (2) invert sugar control, receiving a 32% watery solution of invert sugar; (3) vitamin C control, receiving a watery solution of vitamin C (60mg/L), and (4) vitamin C plus invert sugar, receiving a watery solution of vitamin C and invert sugar. All animals had access to chow and water ad libitum and were treated for 17 weeks. Prediabetes was assessed according to two criteria: obesity (based on body mass indexand peritoneal fat content) and impaired glucose tolerance (assessed by the intraperitoneal glucose tolerance test and expressed as area under the curve) . Results: Group invert sugar control gained significantly more weight (p=0.035) and visceral fat (p<0.001) than groups vitamin C control and vitamin C plus invert sugar. Consequently, groups vitamin C control and vitamin C plus invert sugar had gained as little body mass index as group C by the end of the experiment. Vitamin C decreased the fasting glycemia of both groups supplemented with vitamin C and normalized the glucose tolerance of group vitamin C plus invert sugar, whose area under the curve matched that of group C. Conclusion: Vitamin C has anti-obesogenic and glycemia-lowering effects in Wistar rats, which might be promising to prediabetics. Future studies are needed to understand the anti-obesogenic and anti-hyperglycemic mechanisms of vitamin C in prediabetes.

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