Protective effect of ethanolic root extract of Plumbago indica L. on paracetamol induced hepatotoxicity in rats

2011 ◽  
Vol 5 (20) ◽  
Author(s):  
Aiyalu Rajasekaran
Keyword(s):  
Protective Effect ◽  
Root Extract ◽  
Plumbago Indica

scholarly journals Costus Root Extract Preserves Thyroid Hormones Levels, Thyroglobulin Expression and Thyroid Tissues in Rats Receiving Valproate Sodium

2020 ◽  
Vol 12 (4) ◽  
pp. 304-312
Author(s):  
Marwa Salah Mahmoud
Keyword(s):  
Thyroid Gland ◽  
Protective Effect ◽  
Collagen Fibers ◽  
Control Group ◽  
Albino Rats ◽  
Root Extract ◽  
Color Intensity ◽  
Valproate Sodium ◽  
Saussurea Lappa ◽  
Group I

BACKGROUND: Valproate sodium is an anticonvulsant drug. Saussurea lappa (costus) is a medicinal plant rich with antioxidants. This research aimed to assess the protective effect of costus root extract against valproate sodium-induced thyrotoxicity.METHODS: Eighty adult male albino rats were equally divided into four groups; group I: untreated control, group II: rats were given 200 mg/kg BW valproate sodium orally and daily for 8 weeks, group III: rats were given 300 mg/kg BW costus root extract orally and daily for 8 weeks, and group IV: rats were given combination of valproate sodium and costus root extract. After 8 weeks, blood samples were collected to evaluate T3, T4 and thyroid-stimulating hormone (TSH) levels. Thyroid gland samples were handled for light and electron microscopic investigation. The heights of follicular cells, area % of collagen fibers and color intensity of thyroglobulin immunoreaction were statistically analyzed. RESULTS: After being given valproate sodium as an induction, hormonal assay showed significant decrease in serum T3 and T4 and significant increase of TSH. Follicular and cellular alterations were shown by light and electron microscopes. Morphometric study revealed increased follicular cell height and area % of collagen fibers and decreased color intensity of thyroglobulin. In contrast, costus root extract appeared to have a protective role against valproate sodium-induced thyroid injury. Most of the changes induced by valproate sodium were not observed after supplementation with the plant root extract.CONCLUSION: Valproate sodium has serious effects on the function and structure of thyroid gland, and this study shows that costus root extract could have a protective effect against these effects.KEYWORDS: valproate sodium, rat, thyrotoxicity, Saussurea lappa

scholarly journals Kidney protective effect of acalypha indica linn. root extract in high-fructose and high-cholesterol diet-fed rats

2019 ◽  
Vol 1246 ◽  
pp. 012041
Author(s):  
Anyelir Nielya Mutiara Putri ◽  
Rani Wardani Hakim ◽  
Erni H. Purwaningsih ◽  
Desak Gede Budi Krisnamurti
Keyword(s):  
Protective Effect ◽  
High Cholesterol Diet ◽  
Root Extract ◽  
Cholesterol Diet ◽  
High Cholesterol ◽  
High Fructose ◽  
Acalypha Indica

Protective effect of root extract ofOperculina turpethumlinn. Against paracetamol-induced hepatotoxicity in rats

2006 ◽  
Vol 68 (1) ◽  
pp. 32 ◽  
Author(s):  
SV Suresh Kumar ◽  
C Sujatha ◽  
J Syamala ◽  
B Nagasudha ◽  
SH Mishra
Keyword(s):  
Protective Effect ◽  
Root Extract

scholarly journals The Mechanism of Lotus Root Extract (LRE) as Neuro-Protective Effect in Alzheimer Disease (AD)

2013 ◽  
Vol 24 (3) ◽  
pp. 309-320 ◽  
Author(s):  
Seung-Chul Hong ◽  
Chia-Hung Lee ◽  
Sang-Heon Kim ◽  
Jin-Hee Lee ◽  
Byung-Soo Koo
Keyword(s):  
Alzheimer Disease ◽  
Protective Effect ◽  
Root Extract ◽  
Lotus Root ◽  
Neuro Protective Effect

In vitro study of the Plumbago indica root extract on Fasciola gigantica

2019 ◽  
Author(s):  
N Saowakon ◽  
Y Camchuen ◽  
N Changklungmoa ◽  
P Kueakhai ◽  
P Sobhon
Keyword(s):  
In Vitro Study ◽  
Fasciola Gigantica ◽  
Vitro Study ◽  
Root Extract ◽  
Plumbago Indica

scholarly journals Curative effect of Plumbago indica root extract on thioacetamide induced hepatotoxicity in experimental rats

2017 ◽  
Vol 9 (1) ◽  
pp. 138
Author(s):  
Eldhose Binil ◽  
Kuriakose Jayesh ◽  
Latha Mukalel Sankunni
Keyword(s):  
Liver Damage ◽  
Root Extract ◽  
Dependent Manner ◽  
Curative Effect ◽  
Traditional System ◽  
Root Extracts ◽  
Plumbago Indica ◽  
Antioxidant Markers ◽  
Dose Dependent ◽  
Different Doses

<p>The root parts of <em>Plumbago indica</em> is widely used in the Indian Ayurvedic traditional system. The study was designed to evaluate the hepato curative activity Plumbago<em> Indica</em> (PLBM) methanolic root extracts at different doses (100 and 200 mg/kg bw) against thioacetamide induced liver damage in albino wistar rats. Liver damage was induced by administration of Thioacetamide (100 mg/kg bw) and was assessed by evaluating the activity of liver-function marker enzymes, antioxidant enzymes and lipid peroxidation. The liver sections were evaluated for histopathological changes. PLBM significantly (<em>p </em>≤ 0.05) reversed the elevation of serum liver enzymes and hepatic levels of antioxidant markers. Histopathological findings also confirmed the curative effect of <em>Plumbago Indica</em> in a dose dependent manner. Thus this study scientifically rationale the use of <em>Plumbago indica </em> root as a promising drug against various liver disorders.</p>

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