Association between age-related macular degeneration and 25(OH) vitamin D levels in the Turkish population

Abstract Purpose The aim of this study was to determine the 25-hydroxy vitamin D (25(OH)D) levels in age-related macular degeneration (AMD) patients. Methods Age-related macular degeneration (AMD) patients were classified into four groups: early AMD (N =10), intermediate AMD (N=12), advanced atrophic AMD (N=19) and advanced neovascular AMD (N=52) after undergoing fundus photography. Serum 25(OH)D levels of all subjects were evaluated. From a random control group of 326 patients whose 25(OH)D levels had been measured, a group of 93 were selected to match the age range of the AMD group. We measured 25(OH)D levels during the same period to rule out seasonal variation. Results A total of 93 AMD patients (36 males and 57 females) and 93 healthy individuals (39 males and 54 females) were enrolled in this study with the mean age of 78.96±8.46 vs. 78.80±8.35, respectively. The patients affected by AMD had statistically significant lower 25(OH)D levels (15±10 ng/mL) than the healthy subjects control group (21±14 ng/mL) (p = 0.004). However, the median 25(OH)D levels in early AMD, intermediate AMD, advanced atrophic AMD and advanced neovascular AMD (12.5±7.3; 15±11; 15±8 and 17±11.5, respectively) were not statistically significant (p = 0.442). Conclusion This study shows that patients affected by AMD had lower vitamin D levels compared to healthy subjects. Further research is necessary to investigate the possible association between 25(OH)D levels and AMD.

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Vitamin D status and prevalent early age-related macular degeneration in African Americans and Caucasians: The Atherosclerosis Risk in Communities (ARIC) Study

The journal of nutrition health & aging ◽

10.1007/s12603-016-0827-6 ◽

2016 ◽

Vol 21 (7) ◽

pp. 772-780 ◽

Cited By ~ 5

Author(s):

Amy E. Millen ◽

J. Nie ◽

M. W. Sahli ◽

J. A. Mares ◽

K. J. Meyers ◽

...

Keyword(s):

Vitamin D ◽

African Americans ◽

Macular Degeneration ◽

Age Related Macular Degeneration ◽

Early Age ◽

Vitamin D Status ◽

Atherosclerosis Risk In Communities ◽

Age Related ◽

Atherosclerosis Risk ◽

Aric Study

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Association Between Vitamin D Status and Age-Related Macular Degeneration by Genetic Risk

JAMA Ophthalmology ◽

10.1001/jamaophthalmol.2015.2715 ◽

2015 ◽

Vol 133 (10) ◽

pp. 1171 ◽

Cited By ~ 24

Author(s):

Amy E. Millen ◽

Kristin J. Meyers ◽

Zhe Liu ◽

Corinne D. Engelman ◽

Robert B. Wallace ◽

...

Keyword(s):

Vitamin D ◽

Macular Degeneration ◽

Genetic Risk ◽

Age Related Macular Degeneration ◽

Vitamin D Status ◽

Age Related

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The role of balanced supplementation in diet of age-related macular degeneration patients

OphthaTherapy Therapies in Ophthalmology ◽

10.24292/01.ot.300321.1 ◽

2021 ◽

Vol 8 (1) ◽

pp. 19-25

Author(s):

Iwona Kusz vel Sobczuk ◽

Anna Święch

Keyword(s):

Vitamin D ◽

Immune Response ◽

Macular Degeneration ◽

Vitamin B6 ◽

Age Related Macular Degeneration ◽

Response Modulation ◽

Omega 3 ◽

Age Related ◽

Immune Response Modulation

Aim: The aim of the article was to discuss the role of balanced supplementation in diet of age-related macular degeneration patients. Methods: This review was carried out using comprehensive and systematic literature reports on the role of supplementation of vitamin D, vitamin C, vitamin E, vitamin B6, vitamin B12, zinc, lutein, zeaxanthin, omega-3 acid and folic acid in the prevention of AMD. Results: Vitamins, minerals and carotenoids are essential for the proper retinal function over an inflammation and immune response modulation. Conclusions: Vitamins, minerals and carotenoids discussed in the article have anti-inflammatory and antioxidative properties in the management of AMD progression. Accordingly, it is relevant to assure the appropriate level of these nutrients in a diet of AMD patients.

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