The Association Between Serum Vitamin D Levels and Age-Related Macular Degeneration: A Systematic Meta-Analytic Review

Abstract Purpose The aim of this study was to determine the 25-hydroxy vitamin D (25(OH)D) levels in age-related macular degeneration (AMD) patients. Methods Age-related macular degeneration (AMD) patients were classified into four groups: early AMD (N =10), intermediate AMD (N=12), advanced atrophic AMD (N=19) and advanced neovascular AMD (N=52) after undergoing fundus photography. Serum 25(OH)D levels of all subjects were evaluated. From a random control group of 326 patients whose 25(OH)D levels had been measured, a group of 93 were selected to match the age range of the AMD group. We measured 25(OH)D levels during the same period to rule out seasonal variation. Results A total of 93 AMD patients (36 males and 57 females) and 93 healthy individuals (39 males and 54 females) were enrolled in this study with the mean age of 78.96±8.46 vs. 78.80±8.35, respectively. The patients affected by AMD had statistically significant lower 25(OH)D levels (15±10 ng/mL) than the healthy subjects control group (21±14 ng/mL) (p = 0.004). However, the median 25(OH)D levels in early AMD, intermediate AMD, advanced atrophic AMD and advanced neovascular AMD (12.5±7.3; 15±11; 15±8 and 17±11.5, respectively) were not statistically significant (p = 0.442). Conclusion This study shows that patients affected by AMD had lower vitamin D levels compared to healthy subjects. Further research is necessary to investigate the possible association between 25(OH)D levels and AMD.

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Serum Vitamin D Levels in Different Morphologic Forms of Age Related Cataract

Acta Endocrinologica (Bucharest) ◽

10.4183/aeb.2020.178 ◽

2020 ◽

Vol 16 (2) ◽

pp. 178-182

Author(s):

K Atalay

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Serum Vitamin D ◽

Age Related ◽

Vitamin D Levels

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Association of Serum Vitamin D Levels with Senile Cataract

Pakistan Journal of Ophthalmology ◽

10.36351/pjo.v36i3.1037 ◽

2020 ◽

Vol 36 (3) ◽

Author(s):

Yasir Iqbal Malik ◽

Aqsa Malik ◽

Atteya Zaman ◽

Rabia Shabbir ◽

Masooma Talib

Keyword(s):

Vitamin D ◽

Serum Vitamin ◽

Senile Cataract ◽

P Value ◽

Serum Vitamin D ◽

Age Related ◽

Group I ◽

Vitamin D Levels ◽

Significant Difference ◽

Group Ii

Purpose: To determine vitamin D levels in patients of senile cataract and compare them with age related controlpatients.Study Design: Case control observational study.Place and Duration of Study: Naseer Memorial Hospital, Dadhyal Azad Kashmir from March 2016 to June2017.Material and Methods: Three hundred patients were selected and two groups were designed for the study.Group I included patients having senile cataract of any morphological type. The inclusion criteria were age of 50years or more. Group II was control in which age matched controls that had no cataract were enrolled from theoutpatient clinic. Vitamin D levels were measured by radioimmunoassay technique with Diasorin SR® kit followingthe user’s manual. The collected data was entered in the statistical package for social sciences (SPSS) version21 for analysis. Independent t –test was used to determine the significant difference of means between controlsand patients. P value less than 0.05 was considered as significant.Results: Group I consisted of 65.33 % females and 35.66% males whereas in group II were 68% females and32% males. The mean age of patients was 63.20 ± 9.5 years in group I and 65.5 ± 8.9 years in group II.Statistically no significant difference (p>0.05) was found between mean Vitamin D levels in cataract patients(25.95 ± 3.75 ng/mL vs. and age matched control (29.02 ± 5.11ng/mL).Conclusion: There was no statistically significant difference between the vitamin D levels of cataract patientsand the age matched controls

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Clinical factors correlated with vitamin D deficiency in patients with obesity scheduled for bariatric surgery: A single center experience

International Journal for Vitamin and Nutrition Research ◽

10.1024/0300-9831/a000662 ◽

2020 ◽

Vol 90 (3-4) ◽

pp. 346-352

Author(s):

Vincenzo Pilone ◽

Salvatore Tramontano ◽

Carmen Cutolo ◽

Federica Marchese ◽

Antonio Maria Pagano ◽

...

Keyword(s):

Bariatric Surgery ◽

Vitamin D ◽

Vitamin D Deficiency ◽

Serum Vitamin ◽

Inverse Correlation ◽

Model Assessment ◽

Cross Sectional ◽

Serum Vitamin D ◽

Female Sex ◽

Vitamin D Levels

Abstract. We aim to assess the prevalence of vitamin D deficiency (VDD) in patients scheduled for bariatric surgery (BS), and to identify factors that might be associated with VDD. We conducted a cross-sectional observational study involving all consecutive patients scheduled for BS from 2017 to 2019. The exclusion criteria were missing data for vitamin D levels, intake of vitamin D supplements in the 3 months prior to serum vitamin D determination, and renal insufficiency. A total of 206 patients (mean age and body mass index [BMI] of 34.9 ± 10.7 years, and 44.3 ± 6.99 kg/m2, respectively) met the inclusion criteria and were enrolled for data analysis. VDD (<19.9 ng/mL), severe VDD (<10 ng/mL), and vitamin D insufficiency (20–29.9 ng/mL) were present in 68.8 %, 12.5 %, and 31.2 % of patients, respectively. A significant inverse correlation was found between vitamin D levels and initial BMI, parathyroid hormone, and homeostatic model assessment of insulin resistance (r = −0.280, p < 0.05; r = −0.407, p = 0.038; r = −0.445, p = 0.005), respectively. VDD was significantly more prevalent in patients with higher BMI [−0.413 ± 0.12, CI95 % (−0.659; −0.167), p = 0.006], whereas no significant association between hypertension [−1.005 ± 1.65, CI95 % (−4.338; 2.326), p = 0.001], and diabetes type 2 (T2D) [−0.44 ± 2.20, CI95 % (−4.876; 3.986), p = 0.841] was found. We observed significant association between female sex and levels of vitamin D [6.69 ± 2.31, CI95 % (2.06; 11.33), p = 0.006]. The present study shows that in patients scheduled for BS, VDD deficiency is common and was associated with higher BMI, and female sex.

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