Production and Optimization of Extra-cellular protease from Ganoderma sp.

2019 ◽  
Vol 12 (4) ◽  
pp. 1832
Author(s):  
C. V. Vidhya
Keyword(s):  
Cellular Protease

scholarly journals The novel coronavirus 2019 (2019-nCoV) uses the SARS-coronavirus receptor ACE2 and the cellular protease TMPRSS2 for entry into target cells

2020 ◽  
Author(s):  
Markus Hoffmann ◽  
Hannah Kleine-Weber ◽  
Nadine Krüger ◽  
Marcel Müller ◽  
Christian Drosten ◽  
...  
Keyword(s):  
Risk Assessment ◽  
Biological Properties ◽  
Target Cells ◽  
The Novel ◽  
Sars Coronavirus ◽  
Disease Pathogenesis ◽  
Highly Pathogenic ◽  
Coronavirus Infection ◽  
Novel Coronavirus ◽  
Cellular Protease

AbstractThe emergence of a novel, highly pathogenic coronavirus, 2019-nCoV, in China, and its rapid national and international spread pose a global health emergency. Coronaviruses use their spike proteins to select and enter target cells and insights into nCoV-2019 spike (S)-driven entry might facilitate assessment of pandemic potential and reveal therapeutic targets. Here, we demonstrate that 2019-nCoV-S uses the SARS-coronavirus receptor, ACE2, for entry and the cellular protease TMPRSS2 for 2019-nCoV-S priming. A TMPRSS2 inhibitor blocked entry and might constitute a treatment option. Finally, we show that the serum form a convalescent SARS patient neutralized 2019-nCoV-S-driven entry. Our results reveal important commonalities between 2019-nCoV and SARS-coronavirus infection, which might translate into similar transmissibility and disease pathogenesis. Moreover, they identify a target for antiviral intervention.One sentence summaryThe novel 2019 coronavirus and the SARS-coronavirus share central biological properties which can guide risk assessment and intervention.

scholarly journals Biochemical and Genetic Definition of the Cellular Protease Required for HIV-1 gp160 Processing

1995 ◽  
Vol 270 (7) ◽  
pp. 3154-3159 ◽  
Author(s):  
Alex Franzusoff ◽  
Alison M. Volpe ◽  
Denise Josse ◽  
Sergio Pichuantes ◽  
Joseph R. Wolf
Keyword(s):  
Definition Of ◽  
Hiv 1 ◽  
Cellular Protease

Involvement of tryptase-related cellular protease(s) in human immunodeficiency virus type 1 infection

FEBS Letters ◽  
1989 ◽  
Vol 248 (1-2) ◽  
pp. 48-52 ◽  
Author(s):  
Toshio Hattori ◽  
Atsushi Koito ◽  
Kiyoshi Takatsuki ◽  
Hiroshi Kido ◽  
Nobuhiko Katunuma
Keyword(s):  
Human Immunodeficiency Virus ◽  
Human Immunodeficiency Virus Type ◽  
Virus Type ◽  
Immunodeficiency Virus ◽  
Cellular Protease

scholarly journals Investigation of extra-cellular protease in indigenous bacteria of sea cucumbers as a candidate for bio-detergent material in bio-industry

2020 ◽  
Vol 7 (4) ◽  
pp. 335-349
Author(s):  
Delianis Pringgenies ◽  
◽  
Wilis Ari Setyati ◽  
Nirwani Soenardjo ◽  
Rini Pramesti
Keyword(s):  
Sea Cucumbers ◽  
Indigenous Bacteria ◽  
Cellular Protease

scholarly journals Characterization of a cellular protease that cleaves Pseudomonas exotoxin.

1992 ◽  
Vol 60 (2) ◽  
pp. 497-502 ◽  
Author(s):  
C Fryling ◽  
M Ogata ◽  
D FitzGerald
Keyword(s):  
Pseudomonas Exotoxin ◽  
Cellular Protease
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