Catalase and Superoxide Dismutase (SOD) activity in Swiss Albino mice treated with Ethanolic leaf extract of Bauhinia variegata

2019 ◽  
Vol 12 (9) ◽  
pp. 4259
Author(s):  
Pragati Khare ◽  
Kamal Kishore ◽  
Dinesh Kumar Sharma
Keyword(s):  
Superoxide Dismutase ◽  
Leaf Extract ◽  
Sod Activity ◽  
Swiss Albino Mice ◽  
Bauhinia Variegata ◽  
Albino Mice ◽  
Ethanolic Leaf Extract

scholarly journals Vernonia Amygdalina Del (Bitter Leaf) extract ameliorates isoniazid (INH) induced liver injury in Swiss Albino Mice

2018 ◽  
Author(s):  
Gebreselassie Addisu Tilaye ◽  
Muluken Fekadie Zerihun ◽  
Kasaw Adane Chuffa ◽  
Mahelet Arayaselassie ◽  
Daniel Seifu
Keyword(s):  
Liver Injury ◽  
Leaf Extract ◽  
Drug Clearance ◽  
Vernonia Amygdalina ◽  
Drug Induced ◽  
Standard Drug ◽  
Swiss Albino Mice ◽  
Antitubercular Drugs ◽  
Toxic Injury ◽  
Albino Mice

AbstractLiver plays a central role in the metabolism of drugs. Drug clearance and transformation exposes liver to toxic injury. Antitubercular drugs have been found to be hepatotoxic and potentially lead to drug-induced liver injury. Isoniazid is one of the most hepatotoxic first line antitubercular drugs. Conventional drugs used in the treatment of liver disease are often inadequate and a search for supplementation or alternative drugs for the treatment of hepatic damage is indispensible. Therefore our study aims to investigate the hepatoprotective potential of Vernonia Amygdalina Del (bitter leaf) extract against Isoniazid-induced liver injury in Swiss Albino Mice. Treatment of Mice orally with Vernonia Amygdalina Del extract at dose of 250mg/kg and 375 mg/kg significantly lowered (P<0.05) the serum level of liver enzymes in Isoniazid pretreated mice. The hepatoptotective activity of the extract found to be comparable with the standard drug, Silymarin (100 mg/kg, P.o.). Moreover, treatment with the extract significantly alleviated Isoniazid induced hepatic injury as supported by the photomicrographs of liver section of mice. The data shows aqueous Vernonia Amygdalina Del extract has a very promising hepatoprotective potential against isoniazid-induced liver injury.

scholarly journals Effect of ethanolic leaf extract of Ocimum sanctum on haloperidol-induced catalepsy in albino mice

2007 ◽  
Vol 39 (2) ◽  
pp. 87 ◽  
Author(s):  
S Pemminati ◽  
V Nair ◽  
P Dorababu ◽  
HN Gopalakrishna ◽  
MRSM Pai
Keyword(s):  
Leaf Extract ◽  
Ocimum Sanctum ◽  
Albino Mice ◽  
Ethanolic Leaf Extract
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