Quantification of Terbutaline Sulphate in Pharmaceutical Formulation by UV Spectrophotometric aided Multivariate Calibration Technique

2020 ◽  
Vol 13 (2) ◽  
pp. 767
Author(s):  
RK Karthick ◽  
J Kavitha ◽  
KS Lakshmi
Keyword(s):  
Multivariate Calibration ◽  
Pharmaceutical Formulation ◽  
Calibration Technique ◽  
Terbutaline Sulphate

scholarly journals MULTIVARIATE CALIBRATION TECHNIQUE FOR THE SPECTROPHOTOMETRIC QUANTIFICATION OF IVERMECTIN IN PHARMACEUTICAL FORMULATION

2019 ◽  
pp. 444-451
Author(s):  
MADHAN S ◽  
KAVITHA J ◽  
LAKSHMI KS
Keyword(s):  
Multivariate Calibration ◽  
Limit Of Detection ◽  
Pharmaceutical Formulation ◽  
Regression Equations ◽  
Calibration Technique ◽  
Experimental Conditions ◽  
Pharmaceutical Dosage Form ◽  
Ich Guidelines ◽  
Relative Standard ◽  
Interday Precision

Objective: The present abstract makes the use of multivariate calibration technique for the quantification of ivermectin in pharmaceutical dosage form. Methods: Multivariate calibration technique is based on the use of linear regression equations, by correlating the relation between concentration and absorbance at seven different selected wavelengths. The λmax of ivermectin was found to be 245 nm. The results were treated statistically. This statistical approach gives optimum results by eliminating the fluctuations arising from the instrumental or experimental conditions. Results: The developed method was validated as per the ICH guidelines and was found to be simple, linear, accurate, precise, and reproducible. The method was found to be linear over a concentration range of 5–15 μg/mL with a correlation coefficient (r2) value of about 0.9998. The limit of detection and quantification were found to be 0.029 and 0.087 μg/mL, respectively. The percentage relative standard deviation for intraday and interday precision was found to be in the range of 0.473–1.373 and 0.301–1.617, respectively. The percentage recovery was found within the range of 97.60–101.80% w/w. Conclusion: The results evidence that a simple, linear, precise, accurate, sensitive, and reproducible multivariate calibration technique has been developed and validated for the quantification of ivermectin in bulk and pharmaceutical formulation.

Weak Transient Magnetic Fields Detecting in Thermomagnetic Effect Study of Polymer Material Deformations

2014 ◽  
Vol 687-691 ◽  
pp. 4228-4231
Author(s):  
Sheng Ming Chen ◽  
Ying She Luo ◽  
Jian Xin Su ◽  
Yong Zhong Zhang
Keyword(s):  
Multivariate Calibration ◽  
Three Dimensional ◽  
Effect Study ◽  
Calibration Technique ◽  
Thermomagnetic Effect ◽  
Magnetic Detector ◽  
Hall Sensors ◽  
Compact Design ◽  
Transient Magnetic Fields ◽  
Pixel Matrix

A self-developed magnetic detector is presented, which is made up with 64 Hall sensors assembled as an 8×8 serried array in a 50×50mm quadrate circuit wafer, to catch a weak transient magnetic field. The disadvantage accompanying with compact design is the sharp rise of sensor’s working temperature due to the power consumed is on increasing. An approach in which the 64 Hall elements are connected as a three dimensional magnetic-pixel matrix and are driven by dynamic power is presented. The homologous hardware correction illustrative diagram is provided, including its measuring principle and multivariate calibration technique. The experimental results indicated that the proposed method is a beneficial exploration for sensor power supply.

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