Isotopes Inhalation Rate

Abstract In this study, a new model based on electric circuit theory has been introduced to simulate the dynamics of radioactive chemically inert gases in the human body. For this manner, it is assumed that inert gas is transported through the body to various organs via the blood stream. In this simulation, a voltage source is equivalent to gas generation in the atmosphere, the conductivity is equivalent to the cardiac output of the organ, the capacitor capacitance is equivalent to the volume of blood or tissue and voltage across a capacitor is equivalent to the gas concentration in air or blood or a tissue. This simulation can be used to study the dynamics of any inert gas whose partition coefficients are known. We use this simulation to study the dynamics of radon in human body. The physiologically based pharmacokinetic (PBPK) model that describes the fate of radon in systemic tissue has been used for this simulation. Using this simulation, the effective dose equivalent resulting from inhalation of radon has been estimated. The calculated values agree with the previously reported value. Also, using the model, it has been shown that after inhalation of radon gas, absorbed dose has been decreased in different tissues by increasing the inhalation rate without radon. So that, by doubling the inhalation rate and the rate of cardiac output, the value of the absorbed dose has been decreased 11.88% in the adipose tissue, 25.49% in the red marrow tissue and 20.3% in the liver organ.

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Characterisation of Human Behaviour during Odour Perception

Perception ◽

10.1068/p110221 ◽

1982 ◽

Vol 11 (2) ◽

pp. 221-230 ◽

Cited By ~ 44

Author(s):

David G Laing

Keyword(s):

Initial Step ◽

Sampling Time ◽

Sampling Techniques ◽

Hot Wire ◽

Olfactory Responses ◽

Odour Threshold ◽

Odour Concentration ◽

The Many ◽

Odour Perception ◽

Inhalation Rate

Factors which govern the optimum perception of odours have not yet been defined. This has hindered the development of standard methods and instruments for measuring olfactory responses. As an initial step towards defining these conditions, inhalation rates and volumes, number of sniffs, and sniff duration were measured for twenty-three humans in odour-threshold and odour-intensity tests with pentyl acetate, 1-butanol, and diethylamine. Measurements were made with the aid of a hot-wire anemometer concealed within the outlet of an air-dilution olfactometer. Individuals varied markedly in their sampling techniques but maintained their characteristic sniffing patterns with different odours and olfactory tasks. Only three parameters consistently varied with odour concentration: total volume of odour sampled, total sampling time, and number of sniffs. Maximum inhalation rate was remarkably stable and was independent of the type, concentration, and pleasantness of odour. Values recorded for sniff volumes and inhalation rates indicate that most olfactometers in use do not accommodate human inhalation requirements during a sniffing episode. The many common characteristics in the varied sampling techniques of different subjects suggest that the techniques are close to those providing optimum odour perception. Whether these are inherited or developed through habit or experience is not known.

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Natural Sniffing Gives Optimum Odour Perception for Humans

Perception ◽

10.1068/p120099 ◽

1983 ◽

Vol 12 (2) ◽

pp. 99-117 ◽

Cited By ~ 169

Author(s):

David G Laing

Keyword(s):

Intensity Measures ◽

Olfactory Responses ◽

Standard Procedures ◽

Odour Perception ◽

Inhalation Rate

The characteristics of human sniffing episodes during odour perception have been described in an earlier paper, where it has been suggested that the techniques used by individuals may be close to those providing optimum perception. To investigate this suggestion, threshold and intensity tests with butanol, cyclohexanone, and pentyl acetate have been carried out on twenty-one subjects. Olfactory responses obtained by using natural sniffing techniques were compared with those where the number of sniffs, interval between sniffs, and size of sniffs were varied. The results indicate that it is very difficult to improve on the efficiency of sniffing techniques of individuals and that a single natural sniff provides as much information about the presence and intensity of an odour as do seven or more sniffs. A single natural sniff and the first sniff of a a natural sniffing episode were shown to have similar characteristics and most significantly both were unaffected by changes in the concentration and type of odour. Overall, the results indicate that humans achieve optimum odour perception during threshold and intensity measures with their natural multiple-sniff technique or with a single sniff. For the ‘average’ human this occurs with a sniff of inhalation rate 30 1 min−1, volume 200 cm3, and duration 0.4 s. The use of several sniffs in a sniffing episode appears to be a confirmatory action rather than a necessary one, except for the perception of odour mixtures where several sniffs are likely to be needed to aid discrimination of the components. Data from the present and earlier study provide the information necessary for the development of a standard olfactometer and standard procedures for measuring the olfactory responses of humans.

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