scholarly journals Usefulness of Determining Acquisition Time by True Count Rate Measurement Method for Delivery 18F-FDG PET/CT

2016 ◽  
Vol 72 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Shota Miura ◽  
Satoshi Odashima
Keyword(s):  
Fdg Pet ◽  
Count Rate ◽  
Measurement Method ◽  
Acquisition Time ◽  
Rate Measurement ◽  
Pet Ct ◽  
Fdg Pet Ct

Which is the optimal acquisition time for FDG PET/CT imaging in patients with infective endocarditis?

2012 ◽  
Vol 20 (2) ◽  
pp. 307-309 ◽  
Author(s):  
Carmelo Caldarella ◽  
Lucia Leccisotti ◽  
Giorgio Treglia ◽  
Alessandro Giordano
Keyword(s):  
Infective Endocarditis ◽  
Fdg Pet ◽  
Ct Imaging ◽  
Acquisition Time ◽  
Pet Ct ◽  
Fdg Pet Ct

Optimization of injection dose based on noise-equivalent count rate with use of an anthropomorphic pelvis phantom in three-dimensional 18F-FDG PET/CT

2011 ◽  
Vol 5 (2) ◽  
pp. 115-122 ◽  
Author(s):  
Kazumasa Inoue ◽  
Hideo Kurosawa ◽  
Takashi Tanaka ◽  
Masahiro Fukushi ◽  
Noriyuki Moriyama ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Count Rate ◽  
Three Dimensional ◽  
Pet Ct ◽  
Injection Dose ◽  
18F Fdg ◽  
Fdg Pet Ct ◽  
Noise Equivalent Count Rate ◽  
Noise Equivalent Count

scholarly journals Feasibility of equivalent performance of 3D TOF [18F]-FDG PET/CT with reduced acquisition time using clinical and semiquantitative parameters

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Julia Pilz ◽  
Lukas Hehenwarter ◽  
Georg Zimmermann ◽  
Gundula Rendl ◽  
Gregor Schweighofer-Zwink ◽  
...  
Keyword(s):  
Image Quality ◽  
Fdg Pet ◽  
Lesion Detection ◽  
Whole Body ◽  
Body Region ◽  
Acquisition Time ◽  
Routine Practice ◽  
Short Acquisition Time ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Background High-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability for rapid data acquisition while preserving diagnostic image quality. However, determining a reliable and clinically applicable cut-off of the acquisition time plays an important role in routine practice. This study aimed to assess the diagnostic equivalence of short acquisition time of 57 with routine 75 seconds per bed position (s/BP) of [18F]-fluoro-deoxy-glucose (FDG) PET. Phantom studies applying EARL criteria suggested the feasibility of shortened acquisition time in routine clinical imaging by 3D TOF PET/CT scanners. Ninety-six patients with melanoma, lung or head and neck cancer underwent a standard whole-body, skull base-to-thigh or vertex-to-thigh [18F]-FDG PET/CT examination using the 3D TOF Ingenuity TF PET/CT system (Philips, Cleveland, OH). The [18F]-FDG activity applied was equal to 4MBq per kg body weight. Retrospectively, PET list-mode data were used to calculate a second PET study per patient with a reduced acquisition time of 57 s instead of routine 75 s/BP. PET/CT data were reconstructed using a 3D OSEM TOF algorithm. Blinded patient data were analysed by two nuclear medicine physicians. The number of [18F]-FDG-avid lesions per body region (head&neck, thorax, abdomen, bone, extremity) and image quality (grade 1–5) were evaluated. Semiquantitative analyses were performed by standardized uptake value (SUV) measurements using 3D volume of interests (VOI). The visual and semiquantitative diagnostic equivalence of 214 [18F]-FDG-avid lesions were analysed in the routine standard (75 s/BP) as well as the calculated PET/CT studies with short acquisition time. Statistical analyses were performed by equivalence testing and Bland–Altman plots. Results Lesion detection rate per patient’s body region agreed in > 98% comparing 57 s/BP and 75 s/BP datasets. Overall image quality was determined as equal or superior to 75 s in 80% and 69%, respectively. In the semiquantitative lesion-based analyses, a significant equivalence was found between the 75 s/BP and 57 s/BP PET/CT images both for SUVmax (p = 0.004) and SUVmean (p = 0.003). Conclusion The results of this study demonstrate significant clinical and semiquantitative equivalence between short acquisition time of 57 s/BP and standard 75 s/BP 3D TOF [18F]-FDG PET/CT scanning, which may improve the patient’s workflow in routine practice.

scholarly journals The effect of reduced scan time on response assessment FDG-PET/CT imaging using Deauville score in patients with lymphoma

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Charlotte Hornnes ◽  
Annika Loft ◽  
Liselotte Højgaard ◽  
Flemming Littrup Andersen
Keyword(s):  
Image Quality ◽  
Hodgkin Lymphoma ◽  
Fdg Pet ◽  
Response Assessment ◽  
Acquisition Time ◽  
List Mode ◽  
Deauville Score ◽  
Scan Time ◽  
Pet Ct ◽  
Fdg Pet Ct

Abstract Purpose [18F]Fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) is used for response assessment during therapy in Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). Clinicians report the scans visually using Deauville criteria. Improved performance in modern PET/CT scanners could allow for a reduction in scan time without compromising diagnostic image quality. Additionally, patient throughput can be increased with increasing cost-effectiveness. We investigated the effects of reducing scan time of response assessment FDG-PET/CT in HL and NHL patients on Deauville score (DS) and image quality. Methods Twenty patients diagnosed with HL/NHL referred to a response assessment FDG-PET/CT were included. PET scans were performed in list-mode with an acquisition time of 120 s per bed position(s/bp). From PET list-mode data images with full acquisition time of 120 s/bp and shorter acquisition times (90, 60, 45, and 30 s/bp) were reconstructed. All images were assessed by two specialists and assigned a DS. We estimated the possible savings when reducing scan time using a simplified model based on assumed values/costs for our hospital. Results There were no significant changes in the visually assessed DS when reducing scan time to 90 s/bp, 60 s/bp, 45 s/bp, and 30 s/bp. Image quality of 90 s/bp images were rated equal to 120 s/bp images. Coefficient of variance values for 120 s/bp and 90 s/bp images was significantly < 15%. The estimated annual savings to the hospital when reducing scan time was 8000-16,000 €/scanner. Conclusion Acquisition time can be reduced to 90 s/bp in response assessment FDG-PET/CT without compromising Deauville score or image quality. Reducing acquisition time can reduce costs to the clinic.

scholarly journals Artificial intelligence for reduced dose 18F-FDG PET examinations: A real-world deployment through a standardized framework and business case assessment

2020 ◽  
Author(s):  
Katia Katsari ◽  
Daniele Penna ◽  
Vincenzo Arena ◽  
Giulia Polverari ◽  
Annarita Ianniello ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Real World ◽  
Fdg Pet ◽  
Standard Dose ◽  
Acquisition Time ◽  
Reduced Dose ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract Background To determine whether artificial intelligence (AI) processed PET/CT images of reduced by 33% administered 18-F FDG activity acquired in a single center, were non-inferior to native scans and if so to assess the potential impact of commercialization. Methods SubtlePET™ AI was introduced in a PET/CT center in Italy. Eligible patients referred for 18F-FDG PET/CT were prospectively enrolled. Administered 18F-FDG was reduced to two-thirds of standard dose. Patients underwent one low-dose CT and two sequential PET scans; ‘PET-processed’ with reduced dose and standard acquisition time, and ‘PET-native’ with an elapsed time to simulate standard acquisition time and dose. PET-processed images were reconstructed using SubtlePET™. PET-native images were defined as the standard of reference. The datasets were anonymized and independently evaluated in random order by four blinded readers. The evaluation included subjective image quality (IQ) assessment, lesion detectability and assessment of business benefits. Results From February to April 2020, 61 patients were prospectively enrolled. Subjective IQ was not significantly different between datasets (4.62±0.23, p=0.237) for all scanner models, with ‘almost perfect’ inter-reader agreement. There was no significant difference between datasets in lesions’ detectability, target lesion mean SUVmax value and liver mean SUVmean value (182.75/181.75 [SD:0.71], 9.8/11.4 [SD:1.13], 2.1/1.9 [SD:0.14] respectively). No false-positive lesions were reported in PET-processed examinations. Agreed SubtlePET™ price per examination was 15-20% of FDG savings. Conclusion This is the first real-world study to demonstrate the non-inferiority of AI processed 18F-FDG PET/CT examinations obtained with 66% standard dose and a methodology to define the AI solution price.

scholarly journals For avid glucose tumors, the SUV peak is the most reliable parameter for [18F]FDG-PET/CT quantification, regardless of acquisition time

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Avigaëlle Sher ◽  
Franck Lacoeuille ◽  
Pacôme Fosse ◽  
Laurent Vervueren ◽  
Aurélie Cahouet-Vannier ◽  
...  
Keyword(s):  
Fdg Pet ◽  
Acquisition Time ◽  
Pet Ct ◽  
Reliable Parameter ◽  
18F Fdg ◽  
Fdg Pet Ct

scholarly journals Artificial Intelligence for Reduced Dose 18F-FDG PET Examinations: A Real-World Deployment Through a Standardized Framework and Business Case Assessment

2020 ◽  
Author(s):  
Daniele Penna ◽  
Katia Katsari ◽  
Vincenzo Arena ◽  
Giulia Polverari ◽  
Annarita Ianniello ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Real World ◽  
Fdg Pet ◽  
Standard Dose ◽  
Acquisition Time ◽  
Reduced Dose ◽  
Pet Ct ◽  
Significant Difference ◽  
18F Fdg ◽  
Fdg Pet Ct

Abstract BackgroundTo determine whether artificial intelligence (AI) processed PET/CT images of reduced by 33% administered 18-F FDG activity acquired in a single center, were non-inferior to native scans and if so to assess the potential impact of commercialization. MethodsSubtlePET™ AI was introduced in a PET/CT center in Italy. Eligible patients referred for 18F-FDG PET/CT were prospectively enrolled. Administered 18F-FDG was reduced to two-thirds of standard dose. Patients underwent one low-dose CT and two sequential PET scans; ‘PET-processed’ with reduced dose and standard acquisition time, and ‘PET-native’ with an elapsed time to simulate standard acquisition time and dose. PET-processed images were reconstructed using SubtlePET™. PET-native images were defined as the standard of reference. The datasets were anonymized and independently evaluated in random order by four blinded readers. The evaluation included subjective image quality (IQ) assessment, lesion detectability and assessment of business benefits. ResultsFrom February to April 2020, 61 patients were prospectively enrolled. Subjective IQ was not significantly different between datasets (4.62±0.23, p=0.237) for all scanner models, with ‘almost perfect’ inter-reader agreement. There was no significant difference between datasets in lesions’ detectability, target lesion mean SUVmax value and liver mean SUVmean value (182.75/181.75 [SD:0.71], 9.8/11.4 [SD:1.13], 2.1/1.9 [SD:0.14] respectively). No false-positive lesions were reported in PET-processed examinations. Agreed SubtlePET™ price per examination was 15-20% of FDG savings. ConclusionThis is the first real-world study to demonstrate the non-inferiority of AI processed 18F-FDG PET/CT examinations obtained with 66% standard dose and a methodology to define the AI solution price.

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