Design of MIRA, a low-noise pixelated ASIC for the readout of micro-channel plates

We present the design of the first prototype of MIRA (MIcro-channel plate Readout ASIC) that has been designed to read out Micro-Channel Plates (MCP), in particular for UV spectroscopy. MIRA will be able to detect the cloud of electrons generated by each photon interacting with the MCP, sustaining high local and global count rates to fully exploit the MCP intrinsic dynamic range with low dead time. The main rationale that guided the electronics design is the reduction of the input Equivalent Noise Charge (ENC) in order to allow operations with lower MCP gain, thus improving its lifetime, crucial aspect for long missions in space. MIRA features two selectable analog processing times, 133 ns or 280 ns (i.e. fast mode or slow mode), granting a count rate per pixel of 100 kcps. Moreover, it shows an Equivalent Noise Charge ENC = 17 e r m s − . A spatial resolution of 35 μm and an operation with zero dead time, due to the readout, are targeted. The low noise, high count rate and high spatial resolution requirements are expected by keeping a compact pixel size (35 μm × 35 μm) for a total of 32 × 32 pixels in a 2 mm × 2 mm ASIC area. In this work, the ASIC design is described.

An Algorithm for Individual Dosage in Cadmium–Zinc–Telluride SPECT-Gated Radionuclide Angiography

The aim of the present study was to test an individualised dose without compromising the ease of analysing data when performing equilibrium radionuclide angiography (ERNA) using cadmium–zinc–telluride (CZT) SPECT. From March 2018 to January 2019, 1650 patients referred for ERNA received either an individualised dose of 99mTc-labeled human serum albumin (HSA) according to their age, sex, height, and weight (n = 1567), or a standard dose of 550 MBq (n = 83). The target count rate (CRT) was reduced every two months from 2.7 to 1.0 kcps. A final test with a CRT of 1.7 kcps was run for three months to test whether an agreement within 2% points for the determination of LVEF, on the basis of only two analyses, was obtainable in at least 95% of acquisitions. All the included ERNAs were performed on a dedicated cardiac CZT SPECT camera. When using the algorithm for an individualised dose, we found that agreement between the measured and predicted count rate was 80%. With a CRT of 1.7 kcps, the need for more than two analyses to obtain sufficient agreement for LVEF was 4.9%. Furthermore, this resulted in a mean dose reduction from 550 to 258 MBq. Patients’ weight, height, sex, and age can, therefore, be used for individualising a tracer dose while reducing the mean dose.

Characteristic properties of Planacon MCP-PMTs

A systematic investigation of Planacon MCP-PMTs was performed using 64 XP85002/ FIT-Q photosensors. These devices are equipped with microchannel plates of reduced resistance. Results of a study of their gain stability over time and saturation level in terms of the average anode current are presented. This information allows one to determine the lower limit of the MCP resistance for stable Planacon operation. The spread of the electron multiplication characteristics for the entire production batch is also presented, indicating the remarkably low voltage requirements of these MCP-PMTs. Detection efficiency and noise characteristics, such as dark count rate and afterpulsing level, are also reviewed.

Stellar calibration of the single-photon receiver for satellite-to-ground quantum key distribution

Satellite quantum communication is the technology that allows to deploy large-scale quantum networks with a communication range of thousands kilometres We report the ground receiver for downlink quantum key distribution (QKD) with satellite. An optical part of this system including an active tracking loop is mounted on a 600-mm Ritchey-Chretien telescope and permits to distinguish polarization states to perform QKD between ground and satellite. Moreover, a procedure of calibration the receiver using stars with known brightness is presented. Measurements of the photon count rate of stars in the spectral range of 845 nm - 855 nm are performed and compared with an estimate.

Medipix3 proton and carbon ion measurements across full energy ranges and at clinical flux rates in MedAustron IR1

The Medipix3, a hybrid pixel detector with a silicon sensor, has been evaluated as a beam instrumentation device with proton and carbon ion measurements in the non-clinical research room (IR1) of MedAustron Ion Therapy Center. Protons energies are varied from 62.4 to 800 MeV with 104 to 108 protons per second impinging on the detector surface. For carbon ions, energies are varied from 120 to 400 MeV/amu with 107 to 108 carbon ions per second. Measurements include simultaneous high resolution, beam profile and beam intensity with various beam parameters at up to 1000 FPS (frames per second), count rate linearity and an assessment of radiation damage after the measurement day using an x-ray tube to provide a homogeneous radiation measurement. The count rate linearity is found to be linear within the uncertainties (dominated by accelerator related sources due to special setup) for the measurements without degraders. Various frequency components are identified within the beam intensity over time firstly including 49.98 Hz with standard deviation, σ = 0.29, secondly 30.55 Hz σ = 0.55 and thirdly 252.51 Hz σ = 0.83. A direct correlation between the number of zero counting and noisy pixels is observed in the measurements with the highest flux. No conclusive evidence of long term radiation damage was found as a result of these measurements over one day.

Determination of Coal Ash Content by Neutron-Neutron Logging

The research is aimed at assessing the possibility of studying the ash content of coal seams using neutron-neutron logging in coal exploration wells drilled at the outcrops of coal seams under loose deposits using the materials of experimental work in the South Yakutsk coal basin. The prospects of using neutron-neutron logging to study coal well sections, on the one hand, is determined by the fact that hydrogen content in coal seams normally exceeds its content in the host rocks, and, on the other, by the small cross-sections of neutron capture by carbon. Within the same coal grade, an increase in its ash content both means a decrease in its hydrogen content and an increase in the content of elements with a higher capture cross section. Experimental studies were carried out at the Syllakh coal deposit. An IBN-8-1 type plutonium-beryllium source with an output of 5*104 neutrons/s was used as a fast neutron source, and a highly efficient SNM-17 type helium gas-discharge counter was used as a slow neutron detector. The logging depth provided by the equipment was 10 - 30 cm. During the processing of the obtained field data, a correlation was established between the count rate of neutron-neutron logging and coal ash content. It should be noted that the functional dependence of the count rate of neutron-neutron logging on ash content is not continuous – in the range of ash content of 45 - 55% a certain discontinuity point is observed, after which the functional dependence changes. To simplify the assessment of the dependence, the range of rock ash content above 45% is neglected since bituminous coals with an ash content of more than 45% are classified as carbonaceous rock and are not of industrial interest. A close correlation is established between the count rate of neutron-neutron logging and coal ash content. According to the results of statistical processing, the correlation coefficient is 0.97, which makes it possible to quantitatively determine the ash content according to neutron-neutron logging data. The absolute errors in ash content determination by neutron-neutron logging over the entire dataset are up to 3.625 %. The degree of analytical moisture influence on the data of neutron-neutron logging in determining coal ash content is estimated. No regular changes in the count rate of neutron-neutron logging due to a change in the analytical moisture index have been established. It is noteworthy that, with a sufficiently large dispersion value of the analytical moisture index, the trend line of this parameter regularly changes synchronously with the trend lines of ash content and count rate.

Quantitative SPECT (QSPECT) at high count rates with contemporary SPECT/CT systems

Background Accurate QSPECT is crucial in dosimetry-based, personalized radiopharmaceutical therapy with 177Lu and other radionuclides. We compared the quantitative performance of three NaI(Tl)-crystal SPECT/CT systems equipped with low-energy high-resolution collimators from two vendors (Siemens Symbia T6; GE Discovery 670 and NM/CT 870 DR). Methods Using up to 14 GBq of 99mTc in planar mode, we determined the calibration factor and dead-time constant under the assumption that these systems have a paralyzable behaviour. We monitored their response when one or both detectors were activated. QSPECT capability was validated by SPECT/CT imaging of a customized NEMA phantom containing up to 17 GBq of 99mTc. Acquisitions were reconstructed with a third-party ordered subset expectation maximization algorithm. Results The Siemens system had a higher calibration factor (100.0 cps/MBq) and a lower dead-time constant (0.49 μs) than those from GE (75.4–87.5 cps/MBq; 1.74 μs). Activities of up to 3.3 vs. 2.3–2.7 GBq, respectively, were quantifiable by QSPECT before the observed count rate plateaued or decreased. When used in single-detector mode, the QSPECT capability of the former system increased to 5.1 GBq, whereas that of the latter two systems remained independent of the detectors activation mode. Conclusion Despite similar hardware, SPECT/CT systems’ response can significantly differ at high count rate, which impacts their QSPECT capability in a post-therapeutic setting.

Dual energy window imaging for optimisation of P/V ratios in VP SPECT

Purpose Ventilation–perfusion single-photon emission computed tomography (VP SPECT) plays an important role in pulmonary embolism diagnosis. Rapid results may be obtained using same-day ventilation followed by perfusion imaging, but generally requires careful attention to achieving an optimal count rate ratio (P/V ratio) of ≥ 3:1. This study investigated whether the ratio of counts simultaneously acquired in adjacent primary and Compton scatter energy windows (Eratio) on V SPECT was predictive of final normalised perfusion count rate (PCRnorm) on P SPECT using [99mTc]Tc-macroaggregated albumin (MAA), thus allowing for optimisation of P/V ratios. Methods Same-day VP SPECT studies acquired using standard protocols in adult patients during a 2-year period (training dataset) were assessed. Studies were included provided they were acquired with correct imaging parameters, and injection site imaging and laboratory records were available for quality control and normalised count rate corrections. Extraction of DICOM information, and linear regression were performed using custom Python and R scripts. A predictive tool was developed in Microsoft Excel. This tool was then validated using a second (validation) dataset of same-day studies acquired over a subsequent 7-month period. Accuracy of the prediction tool was assessed by calculating the mean absolute percentage error (MAPE). Results Of 643 studies performed, the scans of 342 participants (median age 30.4 years, 318 female) were included in the training dataset, the analysis of which yielded a significant regression equation (F(1,340) = 1057.3, p < 0.0001), with an adjusted R2 of 0.756 and MSE of 0.001089. A prediction tool designed for routine clinical use was developed for predicting final P/V ratio. Of an additional 285 studies, 198 were included in the second (validation) dataset (median age 29.7 years, 188 female). The Excel-based tool was shown to be 91% accurate (MAPE: 9%) in predicting P/V ratio. Conclusion The relationship between the ratio of simultaneously acquired counts in adjacent energy windows on V SPECT and perfusion count rate after administration of a known activity of [99mTc]Tc-MAA can be linearly approximated. A predictive tool based on this work may assist in optimising the dose and timing of [99mTc]Tc-MAA administration in same-day studies to the benefit of patients and workflows.

Method of automatic correction of neutron monitor data for precipitation in the form of snow in real time

We have carried out an experimental study of the influence of precipitation in the form of snow on measurements of the neutron flux intensity near Earth's surface. We have examined the state of the snow cover and its density, and found out that the density depends on the depth of the snow cover. Using the experimental results, we estimate the neutron absorption path in the snow. Changes in snow cover by 10–12 cm at a depth of 80 cm are shown to cause variations in the monitor count rate with an amplitude of 0.9 %. At the snow depth of 80 cm, the neutron monitor count rate decreases by about 8 %. The observed variations should be attributed to the meteorological effects of cosmic rays. The absorption coefficient of neutrons in the snow was also found from the correlation between the count rate of the neutron monitor and the amount of snow above the detector. We propose a real-time correction of the neutron monitor data for precipitation in the form of snow. For this purpose, we implement continuous monitoring of the amount of snow cover. The monitoring is provided by a snow meter made using a laser rangefinder module. We discuss the results obtained.

Effect of Microwave Heating On The Mechanical Properties and Energy Dissipation Characteristics of Hard Rock

To study the effect of microwave on the weakening mechanism of hard rock, uniaxial compression tests were conducted on granite samples after microwave treatment, and an acoustic emission system was established to monitor the fracture evolution in such rock samples. The effects of microwave irradiation on the stress-strain curve, acoustic emission characteristics, and energy dissipation characteristics of granite were investigated in the experiment. The results show that: 1) With the continuous increase of microwave irradiation power and time, the compaction stage and crack development stage of the sample gradually increase, and the elastic stage gradually becomes shorter; the trend of post-peak stress drop becomes slower, changing from “cliff type” to multi-step type “. The failure of the sample indicates that they become less brittle and more ductile; 2) Microwave irradiation reduces the strength. The overall acoustic emission count rate is weak before the peak and increases rapidly near the peak. The count rate has also changed from sparse to dense, and with the increase in the irradiation power and time, the total acoustic emission count rate increases; 3) From the energy point of view, the weakening of granite by microwave irradiation will not only decrease the energy-storage limit of granite and increase the proportion of dissipated energy in the failure process, but also decrease the rate of release of elastic energy after the peak. Therefore, microwave irradiation will not only reduce the mechanical energy dissipated during damage, but also reduce the intensity of potential dynamic disasters.