Comparison of T2 Weighted, Fat-Suppressed T2 Weighted, and Three-Dimensional (3D) Fast Imaging Employing Steady-State Acquisition (FIESTA-C) Sequences in the Temporomandibular Joint (TMJ) Evaluation

Aim. Osteonecrosis can affect the mandibular condyle, and bone marrow edema may be a precursor in osteonecrosis development in temporomandibular disorder (TMD) patients. Early detection of bone marrow changes is crucial for occurring osteonecrosis. The purpose of this study was to compare the diagnostic value of fast spin-echo T2 weighted (FSE-T2W), fat-suppressed T2W (FS-T2W), and three-dimensional (3D) fast imaging employing steady-state acquisition (FIESTA-C) MR sequences for early detection of bone marrow changes as well as TMJ soft tissue alterations. Methods. A total of 60 joints with TMD were included in this study using a 1.5T MR machine (Signa HDxt, GE, Milwaukee, USA) using a dual surface TMJ coil. Qualitatively, the images were interpreted by two observers for disk configuration, disk position, joint fluid, and bone marrow changes. Quantitatively, signal intensity ratios (SIR) in the TMJ condyle, retrodiscal tissue, disk, and muscle were also measured using all tested sequences. Kappa coefficients were calculated to assess both intra- and interobserver agreements for each image set. The SIR of each sequence was compared using a one-way ANOVA Bonferroni-Dunn test. Results. Overall intraobserver kappa coefficients ranged between 0.35 and 0.88 for joint fluid and between 0.22 and 0.82 for bone marrow changes diagnosis, suggesting high intraobserver agreement for FS-T2W and 3D FIESTA-C sequences than FSE T2W sequence ( p < 0.05 ). 3D FIESTA-C showed higher agreement values for disk configuration and position detection than other sequences. Conclusions. 3D FIESTA-C sequences can be used and incorporated into routine MRI protocols for obtaining high-resolution TMJ MR images due to the short acquisition time and 3D nature of the sequence. Additional studies should be done for dynamic TMJ imaging with this sequence.

CNN-Based Personal Identification System Using Resting State Electroencephalography

As a biometric characteristic, electroencephalography (EEG) signals have the advantages of being hard to steal and easy to detect liveness, which attract researchers to study EEG-based personal identification technique. Among different EEG protocols, resting state signals are the most practical option since it is more convenient to operate than the other protocols. In this paper, a personal identification system based on resting state EEG is proposed, in which data augmentation and convolutional neural network are combined. The cross-validation is performed on a public database of 109 subjects. The experimental results show that when only 14 EEG channels and 0.5 seconds data are employed, the average accuracy and average equal error rate of the system can reach 99.32% and 0.18%, respectively. Compared with some existing representative works, the proposed system has the advantages of short acquisition time, low computational complexity, and rapid deployment using market available low-cost EEG sensors, which further advances the implementation of practical EEG-based identification systems.

Electron Transfer based Ultra-bright Organic Afterglow Nanoprobe for Accurate Molecular Imaging in Mice

Afterglow luminescence can greatly improve the signal-to-background ratio (SBR) of molecule imaging in living animal owing to the no need of real-time light excitation. However, the relatively low luminescence of afterglow nanoprobe and attenuation of maximum intensity (afterglow photobleaching) usually lead to the insufficient sensitivity and the inaccurate quantification for repeated molecular imaging. Furthermore, the requirement of high power of light excitation (up to 1 W/cm2) may result in the inevitable phototoxicity, and the long acquisition time (up to 1 min) make it difficult to detect the rapid biological events. Herein, we design electron-rich trianthracene derivatives (TA)-based organic afterglow nanoparticles (TA-NPs) for high-sensitive, safe, lossless and longitudinal molecular imaging. Notably, a great enhancement of afterglow luminescence performance over the previous reported afterglow nanoparticles is achieved though electron transfer engineering (Table 1): Specifically, TA-NPs can be excited by room light with ultra-low power (58 µW/cm2) and with ultra-short acquisition time (0.01 s). The luminescent intensity of TA-NPs is ~ 500-fold of commonly used organic MEHPPV-based nanoparticles. Negligible afterglow photobleaching in mice is observed even after re-excitation for more than 15 cycles. Such ultra-bright afterglow enables the deep-tissue imaging (up to 6.0 cm) and the ultra-fast afterglow imaging of freely-moving mice in waken state. Moreover, TA-NPs can dynamically and accurately visualize subcutaneous tumor, orthotopic glioma and distinguish the plaque in carotid atherosclerosis. Finally, we develop an afterglow nanoprobe (TA-BHQ), activated only in the presence of Granzyme B, for tracking the time-sensitive Granzyme B activity as a direct way to monitor immunotherapeutic responses.

Gas-Solid Flow in a Fluidized-Particle Tubular Solar Receiver: Off-Sun Experimental Flow Regimes Characterization

The fluidized particle-in-tube solar receiver concept is promoted as an attractive solution for heating particles at high temperature in the context of the next generation of solar power tower. Similar to most existing central solar receivers, the irradiated part of the system, the absorber, is composed of tubes in which circulate the fluidized particles. In this concept, the bottom tip of the tubes is immersed in a fluidized bed generated in a vessel named the dispenser. A secondary air injection, called aeration, is added at the bottom of the tube to stabilize the flow. Contrary to risers, the particle mass flow rate is controlled by a combination of the overpressure in the dispenser and the aeration air velocity in the tube. This is an originality of the system that justifies a specific study of the fluidization regimes in a wide range of operating parameters. Moreover, due to the high value of the aspect ratio, the particle flow structure varies along the tube. Experiments were conducted with Geldart Group A particles at ambient temperature with a 0.045 m internal diameter and 3 m long tube. Various temporal pressure signal processing methods, applied in the case of classical risers, are applied. Over a short acquisition time, a cross-reference of the results is necessary to identify and characterize the fluidization regimes. Bubbling, slugging, turbulent and fast fluidization regimes are encountered and the two operation modes, without and with particle circulation, are compared.

Feasibility of Low-Dose 68Ga-DOTATATE With Short Acquisition Time Using Total-Body PET/CT in Patients With Neuroendocrine Tumor

Purpose To explore the feasibility of a low dose regimen with short acquisition time of 68Ga-DOTATATE total-body PET/CT without compromising image quality of patients with NETs. Methods Fifty-seven consecutive NETs patients who underwent 68Ga-DOTATATE total-body PET/CT, with a low dose regimen (0.8-1.2 MBq/kg) of 68Ga-DOTATATE and acquisition time of 10 min prior to any treatment, were enrolled in the present study. The PET data were split into 1 min, 2 min, 3 min, 4 min, 5 min, 8 min and 10 min reconstruction groups, referenced as R1, R2, R3, R4, R5, R8 and R10. The subjective evaluation of image quality was scored in 5-point Likert scale based on three aspects: the overall impression of the image quality, the image noise, the lesion detectability. The objective image quality was assessed by the signal-to-noise ratio of liver (SNRL), the coefficient of variation (CV), the SUVmax, SUVmean, SD of liver, mediastinal blood pool and lesion, the tumor-liver ratio (TLR), the tumor-mediastinal blood pool-ratio (TMR) of lesion. Results The sufficient subjective image quality with a score of 3.44±0.53 could be obtained at 3 min acquisition duration, with a kappa value of 0.90. In quantitative analysis, the value of SNRL is over 10 in all reconstruction groups. As the acquisition time increases, SNRL was increased and CV was decreased within 3 min, while SNRL and CV showed no significant different between R4-R10. There was no significant different in TMR and TLR of lesion between R1-R10 (all p < 0.05). Referenced as PET images of R10, 90 SSTR-positive lesions are identified, and all those lesions are found in the R1-R10 groups (100%).Conclusion The low-dose (0.8-1.2 MBq/kg) 68Ga-DOTATATE total-body PET/CT not only shortens acquisition time, but maintains a sufficient image quality for the NETs patients.

Quantification of Ceftaroline in Human Plasma Using High-Performance Liquid Chromatography with Ultraviolet Detection: Application to Pharmacokinetic Studies

This study was conducted to develop a rapid, simple and reproducible method for the quantification of ceftaroline in plasma samples by high-performance liquid chromatography with ultraviolet detection (HPLC-UV). Sample processing consisted of methanol precipitation and then, after centrifugation, the supernatant was injected into the HPLC system, working in isocratic mode. Ceftaroline was detected at 238 nm at a short acquisition time (less than 5 min). The calibration curve was linear over the concentration range from 0.25 to 40 µg/mL, and the method appeared to be selective, precise and accurate. Ceftaroline in plasma samples was stable at −80 °C for at least 3months. The method was successfully applied to characterize the pharmacokinetic profile of ceftaroline in two critically ill patients and to evaluate whether the pharmacokinetic/pharmacodynamic (PK/PD) target was reached or not with the dose regimen administered.

Feasibility of equivalent performance of 3D TOF [18F]-FDG PET/CT with reduced acquisition time using clinical and semiquantitative parameters

Background High-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability for rapid data acquisition while preserving diagnostic image quality. However, determining a reliable and clinically applicable cut-off of the acquisition time plays an important role in routine practice. This study aimed to assess the diagnostic equivalence of short acquisition time of 57 with routine 75 seconds per bed position (s/BP) of [18F]-fluoro-deoxy-glucose (FDG) PET. Phantom studies applying EARL criteria suggested the feasibility of shortened acquisition time in routine clinical imaging by 3D TOF PET/CT scanners. Ninety-six patients with melanoma, lung or head and neck cancer underwent a standard whole-body, skull base-to-thigh or vertex-to-thigh [18F]-FDG PET/CT examination using the 3D TOF Ingenuity TF PET/CT system (Philips, Cleveland, OH). The [18F]-FDG activity applied was equal to 4MBq per kg body weight. Retrospectively, PET list-mode data were used to calculate a second PET study per patient with a reduced acquisition time of 57 s instead of routine 75 s/BP. PET/CT data were reconstructed using a 3D OSEM TOF algorithm. Blinded patient data were analysed by two nuclear medicine physicians. The number of [18F]-FDG-avid lesions per body region (head&neck, thorax, abdomen, bone, extremity) and image quality (grade 1–5) were evaluated. Semiquantitative analyses were performed by standardized uptake value (SUV) measurements using 3D volume of interests (VOI). The visual and semiquantitative diagnostic equivalence of 214 [18F]-FDG-avid lesions were analysed in the routine standard (75 s/BP) as well as the calculated PET/CT studies with short acquisition time. Statistical analyses were performed by equivalence testing and Bland–Altman plots. Results Lesion detection rate per patient’s body region agreed in > 98% comparing 57 s/BP and 75 s/BP datasets. Overall image quality was determined as equal or superior to 75 s in 80% and 69%, respectively. In the semiquantitative lesion-based analyses, a significant equivalence was found between the 75 s/BP and 57 s/BP PET/CT images both for SUVmax (p = 0.004) and SUVmean (p = 0.003). Conclusion The results of this study demonstrate significant clinical and semiquantitative equivalence between short acquisition time of 57 s/BP and standard 75 s/BP 3D TOF [18F]-FDG PET/CT scanning, which may improve the patient’s workflow in routine practice.

Ultraviolet-visible/near infrared spectroscopy and hyperspectral imaging to study the different types of raw cotton

Different types of raw cotton were investigated by a commercial ultraviolet-visible/near infrared (UV-Vis/NIR) spectrometer (210–2200 nm) as well as on a home-built setup for NIR hyperspectral imaging (NIR-HSI) in the range 1100–2200 nm. UV-Vis/NIR reflection spectroscopy reveals the dominant role proteins, hydrocarbons and hydroxyl groups play in the structure of cotton. NIR-HSI shows a similar result. Experimentally obtained data in combination with principal component analysis (PCA) provides a general differentiation of different cotton types. For UV-Vis/NIR spectroscopy, the first two principal components (PC) represent 82 % and 78 % of the total data variance for the UV-Vis and NIR regions, respectively. Whereas, for NIR-HSI, due to the large amount of data acquired, two methodologies for data processing were applied in low and high lateral resolution. In the first method, the average of the spectra from one sample was calculated and in the second method the spectra of each pixel were used. Both methods are able to explain ≥90 % of total variance by the first two PCs. The results show that it is possible to distinguish between different cotton types based on a few selected wavelength ranges. The combination of HSI and multivariate data analysis has a strong potential in industrial applications due to its short acquisition time and low-cost development. This study opens a novel possibility for a further development of this technique towards real large-scale processes.