scholarly journals Anti-inflammatory Effect of Portulacae Herba Water Extract on Lipopolysaccharide-activated RAW 264.7 Macrophages

2016 ◽  
Vol 31 (1) ◽  
pp. 61-67
Author(s):  
Jai-Kong Joo ◽  
Hyo-Sang Han ◽  
Young-Jong Lee
2010 ◽  
Vol 48 (8-9) ◽  
pp. 2045-2051 ◽  
Author(s):  
Soo-Jin Heo ◽  
Weon-Jong Yoon ◽  
Kil-Nam Kim ◽  
Gin-Nae Ahn ◽  
Sung-Myung Kang ◽  
...  

2014 ◽  
Vol 42 (04) ◽  
pp. 891-904 ◽  
Author(s):  
Mi Young Song ◽  
Hyo Won Jung ◽  
Seok Yong Kang ◽  
Kyung-Ho Kim ◽  
Yong-Ki Park

The root bark of Lycium barbarum (Lycii radicis cortex, LRC) is used as a cooling agent for fever and night sweats in East Asian traditional medicine. The inhibitory effect of LRC water extract on inflammation is unknown. In this study, the anti-inflammatory effect of LRC was investigated in lipopolysaccharide (LPS)-stimulated mouse macrophage, RAW 264.7 cells. LRC extract significantly decreased the LPS-induced production of inflammatory mediators, nitric oxide (NO), prostaglandin (PG) E2 and pro-inflammatory cytokines, interleukin (IL)-1β and IL-6 in the cells. In addition, LRC extract inhibited the LPS-induced expression of inducible NO synthase (iNOS) and cyclooxygenase (COX)-2 mRNA and protein, and inflammatory cytokines mRNA in the cells. The action mechanism of LRC underlies the blocking of LPS-mediated p38 and Jun N-terminal kinase (JNK), mitogen-activated protein kinases (MAPKs), and the nuclear factor (NF)-κB signaling pathway. These results indicate that LRC extract inhibits the inflammatory response in activated macrophages by down-regulating the transcription levels of inflammatory mediators and blocking the MAPKs and NF-κB pathway.


2019 ◽  
Vol 131 ◽  
pp. 110594 ◽  
Author(s):  
Mabel Guevara ◽  
Eduardo Tejera ◽  
Gabriel A. Iturralde ◽  
Tatiana Jaramillo-Vivanco ◽  
María G. Granda-Albuja ◽  
...  

2016 ◽  
Vol 24 (3) ◽  
pp. 228-236 ◽  
Author(s):  
Ji Hun Jang ◽  
◽  
Ho Kyung Jung ◽  
Jae Hyung Ko ◽  
Mi Ok Sim ◽  
...  

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