scholarly journals On Counting the Number of Consistent Genotype Assignments for Pedigrees

2005 ◽  
Vol 12 (28) ◽  
Author(s):  
Jirí Srba

Consistency checking of genotype information in pedigrees plays an important role in genetic analysis and for complex pedigrees the computational complexity is critical. We present here a detailed complexity analysis for the problem of counting the number of complete consistent genotype assignments. Our main result is a polynomial time algorithm for counting the number of complete consistent assignments for non-looping pedigrees. We further classify pedigrees according to a number of natural parameters like the number of generations, the number of children per individual and the cardinality of the set of alleles. We show that even if we assume all these parameters as bounded by reasonably small constants, the counting problem becomes computationally hard (#P-complete) for looping pedigrees. The border line for counting problems computable in polynomial time (i.e. belonging to the class FP) and #P-hard problems is completed by showing that even for general pedigrees with unlimited number of generations and alleles but with at most one child per individual and for pedigrees with at most two generations and two children per individual the counting problem is in FP.

2012 ◽  
Vol Vol. 14 no. 2 (Graph and Algorithms) ◽  
Author(s):  
Raffaele Mosca

Graphs and Algorithms International audience This article deals with the Maximum Weight Stable Set (MWS) problem (and some other related NP-hard problems) and the class of P-6-free graphs. The complexity status of MWS is open for P-6-free graphs and is open even for P-5-free graphs (as a long standing open problem). Several results are known for MWS on subclasses of P-5-free: in particular, MWS can be solved for k-colorable P-5-free graphs in polynomial time for every k (depending on k) and more generally for (P-5, K-p)-free graphs (depending on p), which is a useful result since for every graph G one can easily compute a k-coloring of G, with k not necessarily minimum. This article studies the MWS problem for k-colorable P-6-free graphs and more generally for (P-6, K-p)-free graphs. Though we were not able to define a polynomial time algorithm for this problem for every k, this article introduces: (i) some structure properties of P-6-free graphs with respect to stable sets, (ii) two reductions for MWS on (P-6; K-p)-free graphs for every p, (iii) three polynomial time algorithms to solve MWS respectively for 3-colorable P-6-free, for 4-colorable P-6-free, and for (P-6, K-4)-free graphs (the latter allows one to state, together with other known results, that MWS can be solved for (P-6, F)-free graphs in polynomial time where F is any four vertex graph).


2014 ◽  
Vol 17 (A) ◽  
pp. 218-229 ◽  
Author(s):  
Qi Cheng ◽  
Daqing Wan ◽  
Jincheng Zhuang

AbstractIn the recent breakthrough paper by Barbulescu, Gaudry, Joux and Thomé, a quasi-polynomial time algorithm is proposed for the discrete logarithm problem over finite fields of small characteristic. The time complexity analysis of the algorithm is based on several heuristics presented in their paper. We show that some of the heuristics are problematic in their original forms, in particular when the field is not a Kummer extension. We propose a fix to the algorithm in non-Kummer cases, without altering the heuristic quasi-polynomial time complexity. Further study is required in order to fully understand the effectiveness of the new approach.


10.29007/v68w ◽  
2018 ◽  
Author(s):  
Ying Zhu ◽  
Mirek Truszczynski

We study the problem of learning the importance of preferences in preference profiles in two important cases: when individual preferences are aggregated by the ranked Pareto rule, and when they are aggregated by positional scoring rules. For the ranked Pareto rule, we provide a polynomial-time algorithm that finds a ranking of preferences such that the ranked profile correctly decides all the examples, whenever such a ranking exists. We also show that the problem to learn a ranking maximizing the number of correctly decided examples (also under the ranked Pareto rule) is NP-hard. We obtain similar results for the case of weighted profiles when positional scoring rules are used for aggregation.


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