scholarly journals Systems biology approaches based discovery of a small molecule inhibitor targeting both c-Met/PARP-1 and inducing cell death in breast cancer

2020 ◽  
Vol 11 (9) ◽  
pp. 2656-2666
Author(s):  
Tian Yu ◽  
Lijia Cheng ◽  
Xueling Yan ◽  
Hang Xiong ◽  
Jie Chen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Death ◽  
Systems Biology ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Parp 1

scholarly journals Combined administration of a small-molecule inhibitor of TRAF6 and Docetaxel reduces breast cancer skeletal metastasis and osteolysis

2020 ◽  
Vol 488 ◽  
pp. 27-39 ◽  
Author(s):  
Ryan T. Bishop ◽  
Silvia Marino ◽  
Giovana Carrasco ◽  
Boya Li ◽  
Richard J. Allen ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Small Molecule ◽  
Skeletal Metastasis ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Combined Administration

Phase 1 study of CB-839, a small molecule inhibitor of glutaminase (GLS) in combination with paclitaxel (Pac) in patients (pts) with triple negative breast cancer (TNBC).

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 1011-1011 ◽  
Author(s):  
Angela DeMichele ◽  
James J. Harding ◽  
Melinda L. Telli ◽  
Pamela N. Munster ◽  
Rana McKay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Small Molecule ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
Phase 1 ◽  
Small Molecule Inhibitor ◽  
Phase 1 Study ◽  
Molecule Inhibitor

Abstract LB-037: Development and preclinical assessment of a first-in-class small molecule inhibitor of the major cell death regulator protein FLIP

2015 ◽  
Author(s):  
Joanna Majkut ◽  
Catherine Higgins ◽  
Adnan Malik ◽  
Zsusannah Nemeth ◽  
Peter Blurton ◽  
...  
Keyword(s):  
Cell Death ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Regulator Protein ◽  
Molecule Inhibitor

Abstract 3768: Targeting of epithelial-to-mesenchyme transition by a novel small molecule inhibitor attenuates prostate and breast cancer invasiveness and bone metastases

2016 ◽  
Author(s):  
Jan Kroon ◽  
Onno van Hooij ◽  
Eugenio Zoni ◽  
Maaike van der Mark ◽  
Geertje van der Horst ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bone Metastases ◽  
Small Molecule ◽  
Small Molecule Inhibitor ◽  
Molecule Inhibitor ◽  
Cancer Invasiveness ◽  
Breast Cancer Invasiveness
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