scholarly journals Oxidized-Desialylated Low-Density Lipoprotein Inhibits the Antitumor Functions of Lymphokine Activated Killer Cells

2021 ◽  
Vol 12 (16) ◽  
pp. 4993-5004
Author(s):  
Jesús S Aguilar Díaz de león ◽  
Honor L Glenn ◽  
Mark Knappenberger ◽  
Chad R Borges
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Lymphokine Activated Killer Cells ◽  
Killer Cells

Anti-phosphorylcholine-opsonized low-density lipoprotein promotes rapid production of proinflammatory cytokines by dendritic cells and natural killer cells

2010 ◽  
Vol 45 (6) ◽  
pp. 720-730 ◽  
Author(s):  
T. Kikuchi ◽  
M. M. El Shikh ◽  
R. M. El Sayed ◽  
D. B. Purkall ◽  
M. M. Elaasser ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Natural Killer Cells ◽  
Natural Killer ◽  
Proinflammatory Cytokines ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Low Density ◽  
Killer Cells ◽  
Rapid Production

Intralysosomal Accumulation of Colloidal Gold-Low Density Lipoprotein Conjugates in Chloroquine-Treated Fibroblasts

1985 ◽  
Vol 43 ◽  
pp. 546-547 ◽  
Author(s):  
Dean A. Handley ◽  
Cynthia M. Arbeeny ◽  
Larry D. Witte
Keyword(s):  
Colloidal Gold ◽  
Cultured Cells ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Coated Vesicle ◽  
Low Density ◽  
Cholesterol Esters ◽  
Cultured Fibroblasts ◽  
Surface Receptors ◽  
Ldl Particles

Low density lipoproteins (LDL) are the major cholesterol carrying particles in the blood. Using cultured cells, it has been shown that LDL particles interact with specific surface receptors and are internalized via a coated pit-coated vesicle pathway for lysosomal catabolism. This (Pathway has been visualized using LDL labeled to ferritin or colloidal gold. It is now recognized that certain lysomotropic agents, such as chloroquine, inhibit lysosomal enzymes that degrade protein and cholesterol esters. By interrupting cholesterol ester hydrolysis, chloroquine treatment results in lysosomal accumulation of cholesterol esters from internalized LDL. Using LDL conjugated to colloidal gold, we have examined the ultrastructural effects of chloroquine on lipoprotein uptake by normal cultured fibroblasts.

Involvement of beta2-glycoprotein I and anticardiolipin antibodies in oxidatively modified low-density lipoprotein uptake by macrophages

1997 ◽  
Vol 107 (3) ◽  
pp. 569-573 ◽  
Author(s):  
Y. HASUNUMA ◽  
E. MATSUURA ◽  
Z. MAKITA ◽  
T. KATAHIRA ◽  
S. NISHI ◽  
...  
Keyword(s):  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Anticardiolipin Antibodies ◽  
Low Density ◽  
Glycoprotein I ◽  
Lipoprotein Uptake ◽  
Oxidatively Modified
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