Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model

Zhelong Li; Ping Zhao; Yajun Zhang; Jia Wang; Chen Wang; Yunnan Liu; Guodong Yang; Lijun Yuan

doi:10.7150/thno.49874

Exosome-based Ldlr gene therapy for familial hypercholesterolemia in a mouse model

Theranostics ◽

10.7150/thno.49874 ◽

2021 ◽

Vol 11 (6) ◽

pp. 2953-2965

Author(s):

Zhelong Li ◽

Ping Zhao ◽

Yajun Zhang ◽

Jia Wang ◽

Chen Wang ◽

...

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Ldlr Gene

Gene Therapy Targeting LDL Cholesterol but not HDL Cholesterol Induces Regression of Advanced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia

Journal of Genetic Syndromes & Gene Therapy ◽

10.4172/2157-7412.1000106 ◽

2011 ◽

Vol 2 (2) ◽

Cited By ~ 11

Author(s):

Rongying Li ◽

Hsu Chao

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Ldl Cholesterol ◽

Hdl Cholesterol

Very Low Density Lipoprotein Receptor Gene Therapy in a Mouse Model of Familial Hypercholesterolemia

Drugs Affecting Lipid Metabolism - Medical Science Symposia Series ◽

10.1007/978-94-009-0311-1_30 ◽

1996 ◽

pp. 249-253

Author(s):

Lawrence Chan ◽

Kunihisa Kobayashi

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Receptor Gene ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Very Low Density Lipoprotein ◽

Low Density ◽

Low Density Lipoprotein Receptor ◽

Density Lipoprotein Receptor

631. In-Vivo LDL Receptor Gene Therapy Is Highly Effective in Reversing Hypercholesterolemia in a Mouse Model of Familial Hypercholesterolemia

Molecular Therapy ◽

10.1016/s1525-0016(16)41073-7 ◽

2003 ◽

Vol 7 (5) ◽

pp. S246 ◽

Cited By ~ 1

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Receptor Gene ◽

Ldl Receptor ◽

Highly Effective

Low-density lipoprotein receptor gene therapy using helper-dependent adenovirus produces long-term protection against atherosclerosis in a mouse model of familial hypercholesterolemia

Gene Therapy ◽

10.1038/sj.gt.3302310 ◽

2004 ◽

Vol 11 (20) ◽

pp. 1540-1548 ◽

Cited By ~ 39

Author(s):

S Nomura ◽

A Merched ◽

E Nour ◽

C Dieker ◽

K Oka ◽

...

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Receptor Gene ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Low Density ◽

Lipoprotein Receptor ◽

Density Lipoprotein Receptor

638. Combined LDL Receptor and ApoA-I Gene Therapy for Advanced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia

Molecular Therapy ◽

10.1016/j.ymthe.2005.07.178 ◽

2005 ◽

Vol 11 ◽

pp. S247-S248

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Ldl Receptor ◽

I Gene

Gene Therapy in a Humanized Mouse Model of Familial Hypercholesterolemia Leads to Marked Regression of Atherosclerosis

PLoS ONE ◽

10.1371/journal.pone.0013424 ◽

2010 ◽

Vol 5 (10) ◽

pp. e13424 ◽

Cited By ~ 42

Author(s):

Sadik H. Kassim ◽

Hui Li ◽

Luk H. Vandenberghe ◽

Christian Hinderer ◽

Peter Bell ◽

...

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Humanized Mouse ◽

Humanized Mouse Model

3P-0887 LDL receptor gene therapy protects against atherosclerosis in a mouse model of familial hypercholesterolemia

Atherosclerosis Supplements ◽

10.1016/s1567-5688(03)91105-6 ◽

2003 ◽

Vol 4 (2) ◽

pp. 256-257

Author(s):

S. Nomura ◽

A. Merched ◽

K. Oka ◽

L. Pastore ◽

A. Beaudet ◽

...

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia ◽

Receptor Gene ◽

Ldl Receptor

174. The Importance of Transgene Optimization in Correcting the Dyslipidemia in a Mouse Model of Familial Hypercholesterolemia by Gene Therapy with AAV8

Molecular Therapy ◽

10.1016/s1525-0016(16)38532-x ◽

2009 ◽

Vol 17 ◽

pp. S69

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Familial Hypercholesterolemia

Faculty Opinions recommendation of CNS-targeted gene therapy improves survival and motor function in a mouse model of spinal muscular atrophy.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725275418.793502456 ◽

2014 ◽

Author(s):

Chris Henderson

Keyword(s):

Gene Therapy ◽

Mouse Model ◽

Spinal Muscular Atrophy ◽

Motor Function ◽

Muscular Atrophy ◽

Targeted Gene Therapy

Faculty Opinions recommendation of IL-17 sequestration via salivary gland gene therapy in a mouse model of Sjogren's syndrome suppresses disease-associated expression of the putative autoantigen Klk1b22.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.725703368.793512522 ◽

2015 ◽

Author(s):

Sarah Gaffen ◽

J Agustin Cruz

Keyword(s):

Gene Therapy ◽

Salivary Gland ◽

Mouse Model ◽

Sjögren’S Syndrome ◽

Sjögren's Syndrome ◽

Sjogren’S Syndrome ◽

Sjogren's Syndrome ◽

Sjögren‘S Syndrome