Monamidocin, a Novel Fibrinogen Receptor Antagonist. II. Biological Activity and Structure-activity Relationships.

A novel series of pyrrole-3-carboxamides targeting EZH2 have been designed and synthesized. The structure–activity relationships were summarized by combining with in vitro biological activity assay and docking results.

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Structure−Activity Relationships of a Novel Class of Endothelin-A Receptor Antagonists and Discovery of Potent and Selective Receptor Antagonist, 2-(Benzo[1,3]dioxol-5-yl)-6-isopropyloxy-4-(4-methoxyphenyl)-2H-chromene-3- carboxylic Acid (S-1255). 1. Study on Structure−Activity Relationships and Basic Structure Crucial for ETAAntagonism

Journal of Medicinal Chemistry ◽

10.1021/jm010382z ◽

2002 ◽

Vol 45 (10) ◽

pp. 2041-2055 ◽

Cited By ~ 60

Author(s):

Natsuki Ishizuka ◽

Ken-ichi Matsumura ◽

Katsunori Sakai ◽

Masafumi Fujimoto ◽

Shin-ichi Mihara ◽

...

Keyword(s):

Carboxylic Acid ◽

Receptor Antagonist ◽

Basic Structure ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity ◽

Endothelin A Receptor ◽

Endothelin A

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Synthesis, biological activity and quantitative structure-activity relationships of N-substituted-3,4-dihydro-2H-1-benzopyran derivatives

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/0960-894x(96)00174-6 ◽

1996 ◽

Vol 6 (10) ◽

pp. 1077-1082 ◽

Cited By ~ 6

Author(s):

C. Marot ◽

C. Comoy ◽

M.C. Viaud ◽

M.C. Rettori ◽

B. Pfeiffer ◽

...

Keyword(s):

Biological Activity ◽

Quantitative Structure ◽

Structure Activity Relationships ◽

Structure Activity ◽

Quantitative Structure Activity Relationships

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ChemInform Abstract: Synthesis and Structure-Activity Relationships of CP-122,721, a Second-Generation NK-1 Receptor Antagonist.

ChemInform ◽

10.1002/chin.199824124 ◽

2010 ◽

Vol 29 (24) ◽

pp. no-no

Author(s):

T. J. ROSEN ◽

K. J. COFFMAN ◽

S. MCLEAN ◽

R. T. CRAWFORD ◽

D. K. BRYCE ◽

...

Keyword(s):

Receptor Antagonist ◽

Second Generation ◽

Structure Activity Relationships ◽

Structure Activity

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Opiate Aromatic Pharmacophore Structure−Activity Relationships in CTAP Analogues Determined by Topographical Bias, Two-Dimensional NMR, and Biological Activity Assays

Journal of Medicinal Chemistry ◽

10.1021/jm9900218 ◽

2000 ◽

Vol 43 (4) ◽

pp. 569-580 ◽

Cited By ~ 14

Author(s):

G. Gregg Bonner ◽

Peg Davis ◽

Dagmar Stropova ◽

Sidney Edsall ◽

Henry I. Yamamura ◽

...

Keyword(s):

Biological Activity ◽

Two Dimensional ◽

Structure Activity Relationships ◽

Structure Activity

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6-Substituted benzimidazoles as new nonpeptide angiotensin II receptor antagonists: synthesis, biological activity, and structure-activity relationships

Journal of Medicinal Chemistry ◽

10.1021/jm00077a007 ◽

1993 ◽

Vol 36 (25) ◽

pp. 4040-4051 ◽

Cited By ~ 130

Author(s):

Uwe J. Ries ◽

Gerhard Mihm ◽

Berthold Narr ◽

Kai M. Hasselbach ◽

Helmut Wittneben ◽

...

Keyword(s):

Biological Activity ◽

Angiotensin Ii ◽

Angiotensin Ii Receptor ◽

Angiotensin Ii Receptor Antagonists ◽

Receptor Antagonists ◽

Structure Activity Relationships ◽

Structure Activity

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AR-A000002, a high affinity 5-HT1B receptor antagonist: Synthesis and structure-activity relationships

European Neuropsychopharmacology ◽

10.1016/s0924-977x(01)80198-x ◽

2001 ◽

Vol 11 ◽

pp. S213-S214

Author(s):

S. Berg ◽

S. Hellberg ◽

M. Linderberg ◽

M. Nylöf ◽

G. Nordvall

Keyword(s):

Receptor Antagonist ◽

Structure Activity Relationships ◽

High Affinity ◽

Structure Activity

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The role of ligand flexibility in predicting biological activity: Structure-activity relationships for aryl hydrocarbon, estrogen, and androgen receptor binding affinity

Environmental Toxicology and Chemistry ◽

10.1002/etc.5620170103 ◽

1998 ◽

Vol 17 (1) ◽

pp. 15-25 ◽

Cited By ~ 2

Author(s):

Steven P. Bradbury ◽

Ovanes G. Mekenyan ◽

Gerald T. Ankley

Keyword(s):

Biological Activity ◽

Androgen Receptor ◽

Binding Affinity ◽

Receptor Binding ◽

Receptor Binding Affinity ◽

Structure Activity Relationships ◽

Aryl Hydrocarbon ◽

Structure Activity ◽

Activity Structure

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Brassinosteroid phytohormones: structure, bioactivity and applications

Brazilian Journal of Plant Physiology ◽

10.1590/s1677-04202002000300001 ◽

2002 ◽

Vol 14 (3) ◽

pp. 143-181 ◽

Cited By ~ 67

Author(s):

Marco António Teixeira Zullo ◽

Günter Adam

Keyword(s):

Biological Activity ◽

Plant Growth ◽

Plant Hormones ◽

Natural Occurrence ◽

Regulatory Activity ◽

Structure Activity Relationships ◽

New Class ◽

Structure Activity ◽

Activity Structure ◽

Steroid Structure

Brassinosteroids are a new class of plant hormones with a polyoxygenated steroid structure showing pronounced plant growth regulatory activity. This review covers their natural occurrence, biological and chromatographic methods for their detection, biosynthesis and metabolism, biological activity, structure-activity relationships and prospective agricultural uses.

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