scholarly journals The vulnerable and the susceptible: The weight of evidenza to stop exploiting activities generating toxic exposures in unprotected and deprived countries

2021 ◽  
Vol 11 ◽  
Author(s):  
Chiara Frazzoli
Keyword(s):  
Author(s):  
Meghan A. Cook ◽  
Pardeep S. Jagpal ◽  
Khin Hnin Pwint ◽  
Lai Lai San ◽  
Saint Saint Kyaw Thein ◽  
...  

The International Health Regulations (2005) promote national capacity in core institutions so that countries can better detect, respond to and recover from public health emergencies. In accordance with the ‘all hazards’ approach to public health risk, this systematic review examines poisoning and toxic exposures in Myanmar. A systematic literature search was undertaken to find articles pertaining to poisoning in Myanmar published between 1998 and 2020. A number of poisoning risks are identified in this review, including snakebites, heavy metals, drugs of abuse, agrochemicals and traditional medicine. Patterns of poisoning presented in the literature diverge from poisoning priorities reported in other lower-middle income countries in the region. The experience of professionals working in a Yangon-based poison treatment unit also indicate that frequently observed poisoning as a result of pharmaceuticals, methanol, and petroleum products was absent from the literature. Other notable gaps in the available research include assessments of the public health burden of poisoning through self-harm, household exposures to chemicals, paediatric risk and women’s occupational risk of poisoning. There is a limited amount of research available on poisoning outcomes and routes of exposure in Myanmar. Further investigation and research are warranted to provide a more complete assessment of poisoning risk and incidence.


1992 ◽  
Vol 5 (6) ◽  
pp. 312-316 ◽  
Author(s):  
Werner Kalow

A young science serves its purpose if it leads not only to new knowledge, but to new insights and concepts. This article opens with examples to illustrate some former thinking that the introduction of pharmacogenetic has overcome. Pharmacogenetic case histories from discovery to the present illustrate the interlocking of observations, technical advances, and changing concepts. There are striking biological similarities between pharmacogenetics and those inborn factors that cause resistance to infectious disease: Both represent person-to-person variations that may help the survival of populations, one when facing massive toxic exposures, the other when facing plagues and epidemics. Thus pharmacogenetics represents a biologically necessary variability of the defenses against chemical intruders, and this includes drugs. While this variability is desirable, drug toxicity occurring on the basis of this variability must be avoided. The most successful defendants against toxicity due to polymorphic (ie, high incidence) variants should be the designers of new drugs. The only defender concerned with rare variants can be the attentive clinician.


Author(s):  
Meghan A Cook ◽  
Pardeep Jagpal ◽  
Khin Hnin Pwint ◽  
Lai Lai San ◽  
Saint Saint Kyaw Thein ◽  
...  

The International Health Regulations (2005) promote national capacity in core institutions so countries can better detect, respond to and recover from public health emergencies. In accordance with the ‘all hazards’ approach to public health risk, this systematic review examines poisoning and toxic exposures in Myanmar. A systematic literature search was undertaken to find articles pertaining to poisoning in Myanmar published between 1998 and 2020. A number of poisoning risks are identified in this review including snakebites, heavy metals, drugs of abuse, agro-chemicals and traditional medicine. Patterns of poisoning presented in the literature diverge from poisoning priorities reported in other lower-middle income countries in the region. The expe-rience of professionals working in a Yangon-based poison treatment unit indicates that frequently observed poisoning as a result of substances including pharmaceuticals, methanol, and petroleum products were absent from the literature. Other notable gaps in the available research include assessments of the public health burden of poisoning through self-harm, household exposures to chemicals, paediatric risk and women’s occupational risk of poisoning. There is a limited amount of research available on poisoning outcomes and routes of exposure in Myanmar. Further inves-tigation and research is warranted to provide a more complete assessment of poisoning risk and incidence.


2013 ◽  
pp. 317-325
Author(s):  
Blake A. Froberg
Keyword(s):  

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