scholarly journals Peer Review #2 of "The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes (v0.1)"

2019 ◽  
Author(s):  
E Valo
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Peer Review ◽  
Urinary Biomarkers ◽  
Early Diabetic Nephropathy

scholarly journals The role of serum and urinary biomarkers in the diagnosis of early diabetic nephropathy in patients with type 2 diabetes

PeerJ ◽  
2019 ◽  
Vol 7 ◽  
pp. e7079 ◽  
Author(s):  
Deyuan Zhang ◽  
Shandong Ye ◽  
Tianrong Pan
Keyword(s):  
Type 2 Diabetes ◽  
Diabetic Nephropathy ◽  
Early Stage ◽  
Area Under The Curve ◽  
Diagnostic Value ◽  
Urinary Biomarkers ◽  
Necrosis Factor Alpha ◽  
Tnf Α

Background Previous studies have shown that a variety of biomarkers are closely related to the occurrence and development of early-stage diabetic nephropathy (DN) in patients. The aim of this study was to evaluate the role of multiple sera and urinary biomarkers in the diagnosis of early-stage DN in patients with type 2 diabetes. Methods We enrolled 287 patients with type 2 diabetes, who were classified into normoalbuminuria (n = 144), microalbuminuria (n = 94), or macroalbuminuria (n = 49) groups based on their urine albumin to creatinine ratios (UACR), along with 42 healthy controls. We assessed 13 biomarkers, including transferrin (Tf), immunoglobulin G (IgG), podocalyxin, neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-glucosaminidase, α-1-microglobulin, 8-hydroxy-deoxyguanosine, tumor necrosis factor-alpha (TNF-α), and interleukin-18 in urine samples, along with cystatin C, total bilirubin, and uric acid in sera samples, to evaluate their diagnostic roles. From the measurements, the blood neutrophil to lymphocyte ratio was also calculated. Results Urinary Tf, IgG, NGAL, and TNF-α were significantly related to the UACR. We calculated the area under the receiver operating characteristic curves (area under the curve) and found that urinary IgG (0.894), NGAL (0.875), Tf (0.861), TNF-α (0.763), and the combination of urinary Tf + IgG + TNF-α + NGAL (0.922) showed good diagnostic value for early-stage DN. Conclusions Urinary Tf, IgG, NGAL, TNF-α, and the combination of all four biomarkers demonstrated excellent diagnostic value for early-stage DN in patients with type 2 diabetes.

Gender bias in the genetic vulnerability towards type 2 diabetes and diabetic nephropathy: Role of forkhead box Protein3 transcription factor gene variants

Gene ◽  
2021 ◽  
Vol 774 ◽  
pp. 145426
Author(s):  
Swetha Chikoti ◽  
Umme Najiya Mahwish ◽  
Sree Bhushan Raju ◽  
Sumanlatha Gaddam ◽  
Parveen Jahan
Keyword(s):  
Type 2 Diabetes ◽  
Transcription Factor ◽  
Diabetic Nephropathy ◽  
Gender Bias ◽  
Gene Variants ◽  
Transcription Factor Gene ◽  
Factor Gene ◽  
Forkhead Box

Role of omentin 1 and IL-6 in type 2 diabetes mellitus patients with diabetic nephropathy

2018 ◽  
Vol 12 (1) ◽  
pp. 23-26 ◽  
Author(s):  
Gandhipuram Periyasamy Senthilkumar ◽  
Melepallappil Sabeenakumari Anithalekshmi ◽  
Md. Yasir ◽  
Sreejith Parameswaran ◽  
Rajaa muthu Packirisamy ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Diabetic Nephropathy
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