Triple Negative Status is a Poor Prognostic Indicator in Chinese Women with Breast Cancer: a Ten Year Review

Solid papillary carcinoma (SPC) is considered a rare malignant breast tumor. Maluf and Koerner first reported this disease entity as a special type of ductal carcinoma in situ with several characteristic histopathological features, including low-grade cellular atypia, intracellular or extracellular mucin deposition, and solid papillary growth pattern, as well as neuroendocrine differentiation. The present paper describes a case of SPC with bcl-2 expression, which is known as a marker for malignancy of neuroendocrine tumors. Interestingly, despite bcl-2 expression being a poor prognostic indicator of neuroendocrine tumors, the patient with this tumor has achieved long-term survival (approximately 6 years) at the time of writing this report. Because previous investigators reported that bcl-2 expression might play a role in the inhibition of the development of breast cancer, we suggest that bcl-2 expression might reflect a good prognosis in patients with SPC, rather than being a poor prognostic indicator, as it is in several types of neuroendocrine tumor. However, to confirm this hypothesis, further investigation is required.

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SF3B1 mutation is a poor prognostic indicator in luminal B and progesterone receptor-negative breast cancer patients

Oncotarget ◽

10.18632/oncotarget.22983 ◽

2017 ◽

Vol 8 (70) ◽

pp. 115018-115027 ◽

Cited By ~ 7

Author(s):

Xing Fu ◽

Ming Tian ◽

Jia Gu ◽

Teng Cheng ◽

Ding Ma ◽

...

Keyword(s):

Breast Cancer ◽

Progesterone Receptor ◽

Cancer Patients ◽

Prognostic Indicator ◽

Breast Cancer Patients ◽

Luminal B ◽

Poor Prognostic Indicator

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Hyperinsulinemia promotes aberrant histone acetylation in triple negative breast cancer

10.1101/503201 ◽

2018 ◽

Author(s):

Parijat Senapati ◽

Christine Thai ◽

Angelica Sanchez ◽

Emily J Gallagher ◽

Derek LeRoith ◽

...

Keyword(s):

Breast Cancer ◽

Histone Acetylation ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Prognostic Indicator ◽

Gene Promoters ◽

Genome Wide ◽

Altered Gene ◽

The Impact

AbstractExcess levels of insulin relative to glucose in the blood, or hyperinsulinemia, is considered to be a poor prognostic indicator for patients with triple negative breast cancer (TNBC). While this association has been recognized for some time, the mechanistic role of hyperinsulinemia in promoting TNBC remains unclear. We show that insulin treatment leads to genome-wide increase in histone acetylation, in particular at H3K9, through the PI3K/AKT/mTOR pathway in MDA-MB-231 cells. Genome-wide analysis showed that the increase in histone acetylation occurs primarily at gene promoters. In addition, insulin induces higher levels of reactive oxygen species and DNA damage foci in cells. In vivo, hyperinsulinemia also enhances growth of MDA-MB-231 derived tumors through increased histone acetylation. These results demonstrate the impact of hyperinsulinemia on altered gene regulation through chromatin and the importance of targeting hyperinsulinemia-induced processes that lead to chromatin dysfunction in TNBC.

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Genetic evaluation of BRCA1-A complex genes with triple-negative breast cancer susceptibility in Chinese women

Oncotarget ◽

10.18632/oncotarget.7112 ◽

2016 ◽

Vol 7 (9) ◽

pp. 9759-9772

Author(s):

Hong Ling ◽

Shan Li ◽

Yang Wu ◽

Yi-Zi Zheng ◽

Feng Qiao ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative Breast Cancer ◽

Triple Negative ◽

Cancer Susceptibility ◽

Chinese Women ◽

Breast Cancer Susceptibility ◽

Genetic Evaluation

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Prevalence of BRCA1 mutations in women with triple-negative breast cancer: A systematic review.

Journal of Clinical Oncology ◽

10.1200/jco.2011.29.27_suppl.181 ◽

2011 ◽

Vol 29 (27_suppl) ◽

pp. 181-181

Author(s):

N. M. Tun ◽

G. M. Villani ◽

K. Ong

Keyword(s):

Breast Cancer ◽

Systematic Review ◽

Triple Negative Breast Cancer ◽

Prevalence Rate ◽

Triple Negative ◽

Chinese Women ◽

Chinese Patients ◽

Ashkenazi Jewish ◽

Brca1 Mutations ◽

Mesh Terms

181 Background: We have reported a strong association between “triple-negative” breast cancer (TNBC) [estrogen receptor (ER) and progesterone receptor (PR) negative, HER2 negative] and the risk of having BRCA1 mutations in a meta-analysis. We hereby present a systematic review of a larger pool of specific data investigating the overall prevalence of BRCA1 mutations in women with TNBC. Methods: A Medline search combining the MeSH terms “BRCA” and “triple” and “negative” yielded 37 articles. A similar search in ASCO abstracts yielded 18 relevant articles. Prevalence in each study population as well as the overall prevalence was calculated. Results: 13 eligible studies (from year 2006 to 2011) including 1075 women with TNBC were identified. Out of 13, 1 study each was carried out on Ashkenazi Jewish and Hong Kong Chinese women respectively. Overall prevalence of BRCA1 mutations in women with TNBC is 20.93% (225 out of 1075) (range = 4.8%–43%). Ashkenazi Jewish women with TNBC have a higher-than-average prevalence of BRCA1 mutations (29.2%) although it is lower than the prevalence rates of some study populations. A remarkably low prevalence rate of BRCA1 mutations (4.8%) is found in Chinese women with TNBC. Conclusions: In view of the overall high prevalence rate of BRCA1 mutations (20.93%) in women with TNBC, genetic testing should be discussed with patients with TNBC. Further studies are suggested to evaluate the molecular basis of interestingly low BRCA1 prevalence (4.8%) in Chinese patients with TNBC.

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Heterogeneity of Breast Cancer Associations with Common Genetic Variants inFGFR2according to the Intrinsic Subtypes in Southern Han Chinese Women

BioMed Research International ◽

10.1155/2015/626948 ◽

2015 ◽

Vol 2015 ◽

pp. 1-9 ◽

Cited By ~ 7

Author(s):

Huiying Liang ◽

Xuexi Yang ◽

Lujia Chen ◽

Hong Li ◽

Anna Zhu ◽

...

Keyword(s):

Breast Cancer ◽

Triple Negative ◽

Chinese Women ◽

Intrinsic Subtype ◽

Han Chinese ◽

Dependent Manner ◽

Intrinsic Subtypes ◽

Luminal A ◽

Luminal B ◽

Common Genetic Variants

GWAS have identified variation in theFGFR2locus as risk factors for breast cancer. Validation studies, however, have shown inconsistent results by ethnics and pathological characteristics. To further explore this inconsistency and investigate the associations ofFGFR2variants with breast cancer according to intrinsic subtype (Luminal-A, Luminal-B, ER−&PR−&HER2+, and triple negative) among Southern Han Chinese women, we genotyped rs1078806, rs1219648, rs2420946, rs2981579, and rs2981582 polymorphisms in 609 patients and 882 controls. Significant associations with breast cancer risk were observed for rs2420946, rs2981579, and rs2981582 with OR (95% CI) per risk allele of 1.19 (1.03–1.39), 1.24 (1.07–1.43), and 1.17 (1.01–1.36), respectively. In subtype specific analysis, above three SNPs were significantly associated with increased Luminal-A risk in a dose-dependent mannerPtrend<0.01; however, only rs2981579 was associated with Luminal-B, and none were linked to ER−&PR− subtypes (ER−&PR−&HER2+ and triple negative). Haplotype analyses also identified common haplotypes significantly associated with luminal-like subtypes (Luminal-A and Luminal-B), but not with ER−&PR− subtypes. Our results suggest that associations ofFGFR2SNPs with breast cancer were heterogeneous according to intrinsic subtype. Future studies stratifying patients by their intrinsic subtypes will provide new insights into the complex genetic mechanisms underlying breast cancer.

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