scholarly journals Increased Risk of Childhood Acute Lymphoblastic Leukemia (ALL) by Prenatal and Postnatal Exposure to High Voltage Power Lines : A Case Control Study in Isfahan, Iran

2015 ◽  
Vol 16 (6) ◽  
pp. 2347-2350 ◽  
Author(s):  
Maral Mazloomi Tabrizi ◽  
Sepideh Arbabi Bidgoli
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
High Voltage ◽  
Case Control Study ◽  
Lymphoblastic Leukemia ◽  
Case Control ◽  
Power Lines ◽  
Postnatal Exposure ◽  
Increased Risk ◽  
High Voltage Power Lines ◽  
Control Study

scholarly journals IKZF1 genetic variants rs4132601 and rs11978267 and acute lymphoblastic leukemia risk in Tunisian children: a case-control study

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Sana Mahjoub ◽  
Vera Chayeb ◽  
Hedia Zitouni ◽  
Rabeb M. Ghali ◽  
Haifa Regaieg ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Case Control Study ◽  
Lymphoblastic Leukemia ◽  
Case Control ◽  
Snp Genotyping ◽  
Control Subjects ◽  
False Discovery ◽  
Increased Risk ◽  
The Common ◽  
Control Study

Abstract Background Associations between IKZF1 gene variants and Acute Lymphoblastic Leukemia (ALL) was recently reported. We examined whether the common IKZF1 polymorphisms rs4132601 T/G and rs111978267 A/G are associated with ALL among a Tunisian pediatric cohort. Methods This case-control study involved 170 patients with ALL and 150 control subjects. SNP genotyping was performed by TaqMan® SNP Genotyping Assay. Results The minor allele G of IKZF1 gene polymorphism rs4132601 T/G was significantly higher in ALL cases than in control subjects (P = 0.029), with 1.54-fold increased risk of ALL. The association of rs4132601 with ALL was seen under co-dominant (P = 0.009), recessive (P = 0.006), and additive (P = 0.027) genetic models, of which the co-dominant (P = 0.027) and recessive (P = 0.027) association remained significant after adjusting for covariates, and False Discovery Rate correction. In contrast, no association was noted for rs111978267 variant. Two-locus (rs4132601-rs11978267) IKZF1 haplotype analysis demonstrated association of GA (P = 0.053), with increased ALL risk [OR (95% CI) = 1.58 (1.00–2.51)], which remained significant after controlling for key covariates [aP = 0.046; aOR (95% CI) = 1.61 (1.01–2.57)]. Conclusion We demonstrated the association of IKZF1 polymorphism rs4132601 T/G with increased risk of ALL among Tunisian pediatric cohort, with altered phenotypic changes among ALL patients.

scholarly journals Preterm birth among women living within 600 meters of high voltage overhead Power Lines: a case-control study

2017 ◽  
Vol 55 (3) ◽  
pp. 145-150 ◽  
Author(s):  
Taktom Sadeghi ◽  
Amirmasoud Ahmadi ◽  
Maryam Javadian ◽  
Sayyed Asghar Gholamian ◽  
Mouloud Agajani Delavar ◽  
...  
Keyword(s):  
Preterm Birth ◽  
High Voltage ◽  
Birth Defect ◽  
Case Control Study ◽  
Case Control ◽  
Power Lines ◽  
Spontaneous Preterm Birth ◽  
Overhead Power Lines ◽  
High Voltage Power Lines ◽  
Control Study

Abstract Aim. The issue of preterm birth due to exposure to magnetic fields from power lines is unclear. Exposure to electromagnetic field in uterus has been hypothesized as possible preterm birth. The aim of the present study was to determine whether living closer to high voltage power lines increased the risk of preterm labor. Methods. In a nested case-control study, 135 cases of singleton live spontaneous preterm birth in Rohani hospital, Babol, Iran, during the period between 2013 and 2014 were studied. The 150 control subjects were singleton term live birth in the same year of birth and city of residence using randomized-digit dialing. The shortest distance to any of the high voltage power lines to the maternal residence during pregnancy was measured using ArcGIS software for every case and control. To test the association between the preterm births and the residential proximity to power lines, stepwise multiple logistic regression was used. Results. There were 28 households, 20 cases (14.8%) and 8 controls (5.3%) situated within 600 meters of high voltage power lines. The adjusted OR for spontaneous preterm birth and birth defect in women who were living in less than 600 meters from high voltage power lines was higher compared to those living at farther distance (OR = 3.28, CI: 1.37 to 7.85) and (OR = 5.05, CI: 1.52 to 16.78), respectively. Conclusions. Therefore, installing overhead power lines and stations within 600 meters or making overhead underground would be useful in the prevention of both preterm birth and birth defect.

scholarly journals Are Children Living Near High-Voltage Power Lines at Increased Risk of Acute Lymphoblastic Leukemia?

2000 ◽  
Vol 151 (5) ◽  
pp. 512-515 ◽  
Author(s):  
R. A. Kleinerman ◽  
W. T. Kaune ◽  
E. E. Hatch ◽  
S. Wacholder ◽  
M. S. Linet ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
High Voltage ◽  
Lymphoblastic Leukemia ◽  
Power Lines ◽  
Increased Risk ◽  
High Voltage Power Lines

Progranulin in the diagnosis of Acute Lymphoblastic Leukemia: A case-control study

2019 ◽  
Vol 6 (6) ◽  
pp. 1-5
Author(s):  
Mohamed Azzazi ◽  
Nevine Mostafa ◽  
Hany Hegab ◽  
Amro El-Ghammaz ◽  
Amir Mahmoud
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Case Control Study ◽  
Lymphoblastic Leukemia ◽  
Case Control ◽  
Control Study
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