scholarly journals Cytotoxic Activity Screening of Fungal Extracts Derived from the West Sumatran Marine Sponge Haliclona fascigera to Several Human Cell Lines: Hela, WiDr, T47D and Vero

2007 ◽  
Vol 4 (1) ◽  
pp. 20-27 ◽  
Author(s):  
Sri Nurestri Abd Malek ◽  
Norhanom Abdul Wahab ◽  
Hashim Yaacob ◽  
Sim Kae Shin ◽  
Hong Sok Lai ◽  
...  

Planta Medica ◽  
2014 ◽  
Vol 80 (16) ◽  
Author(s):  
S Schneider ◽  
N Srirangan ◽  
M Wurster ◽  
U Lindequist ◽  
M Lalk

2012 ◽  
Vol 7 (8) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Luis A. Sánchez ◽  
Dionisio Olmedo ◽  
José Luis López-Pérez ◽  
Todd D. Williams ◽  
Mahabir P. Gupta

In the course of our search for antineoplasic agents from Panamanian Flora, two new alkylresorcinols: 1-(2,6-dihydroxyphenyl)octan-1-one (1) and (+)-1-(3-(1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-1-one (2), together with three known compounds, (1 R, 2 R)-1-(benzo[ d][1,3]dioxol-5-yl)propane-1,2,3-triol (3), (+)-aptosimon (4) and (-)-sesamin (5), were identified from the leaves of Homalomena wendlandii Schott (Araceae). Their structures were established by 1D and 2D NMR and IR spectroscopic, and MS methods. Compound 2 exhibited IC50 values of 3.3, 5.8 and 4.0 μg/mL against MCF-7, SF-268 and H-460 cancer human cell lines, respectively.


2008 ◽  
Vol 3 (8) ◽  
pp. 1934578X0800300
Author(s):  
Mona M. Marzouk ◽  
Salwa A. Kawashty ◽  
Lamyaa F. Ibrahium ◽  
Nabiel A. M. Saleh ◽  
Abdel-Ssalam M. Al-Nowaihi

Two new kaempferol glycosides, kaempferol 3- O-(2″-α-L-rhamnopyranosyl)-β-L-arabinopyranoside-7- O-α-L-rhamnopyranoside and kaempferol 3- O-(2″-α-L-rhamnopyranosyl)-β-L-arabinopyranoside-7- O-α-L-rhamnopyranoside-4′- O-β-D-glucopyranoside were isolated along with four known flavonols from Matthiola longipetala (subsp. livida) (Delile) Maire growing in Egypt. Their structures were established on the basis of detailed chemical and spectral analysis. The cytotoxic activity of the alcoholic extract against Cervix (HELA) and Colon (HCT116) human cell lines showed IC50 values of 22.1 and 53.7 μg/mL, respectively. No activity was found against liver (HEPG2) carcinoma cells.


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