Two New Alkylresorcinols from Homalomena wendlandii and Their Cytotoxic Activity
2012 ◽
Vol 7
(8)
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pp. 1934578X1200700
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Keyword(s):
2D Nmr
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In the course of our search for antineoplasic agents from Panamanian Flora, two new alkylresorcinols: 1-(2,6-dihydroxyphenyl)octan-1-one (1) and (+)-1-(3-(1-(2,6-dihydroxyphenyl)butyl)-2,6-dihydroxyphenyl)octan-1-one (2), together with three known compounds, (1 R, 2 R)-1-(benzo[ d][1,3]dioxol-5-yl)propane-1,2,3-triol (3), (+)-aptosimon (4) and (-)-sesamin (5), were identified from the leaves of Homalomena wendlandii Schott (Araceae). Their structures were established by 1D and 2D NMR and IR spectroscopic, and MS methods. Compound 2 exhibited IC50 values of 3.3, 5.8 and 4.0 μg/mL against MCF-7, SF-268 and H-460 cancer human cell lines, respectively.
2007 ◽
Vol 4
(1)
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pp. 20-27
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Keyword(s):
2010 ◽
Vol 6
(3)
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pp. 180-187
2014 ◽
Vol 173
(3)
◽
pp. 731-740
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Keyword(s):