scholarly journals Synthesis, Biological Evaluation, and Docking Analysis of Methyl Hydroquinone and Bromo Methyl Hydroquinone as Potent Cyclooxygenase (COX-1 and COX-2) Inhibitors

2018 ◽  
Vol 8 (7) ◽  
pp. 16-20 ◽  
Keyword(s):  
Biological Evaluation ◽  
Docking Analysis ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
Cox 1

scholarly journals A Series of COX-2 Inhibitors Endowed with NO-Releasing Properties: Synthesis, Biological Evaluation, and Docking Analysis

ChemMedChem ◽  
2016 ◽  
Vol 11 (16) ◽  
pp. 1804-1811 ◽  
Author(s):  
Sara Consalvi ◽  
Giovanna Poce ◽  
Rino Ragno ◽  
Manuela Sabatino ◽  
Concettina La Motta ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Docking Analysis ◽  
Cox 2 ◽  
Cox 2 Inhibitors

scholarly journals Synthesis, biological evaluation and docking analysis of a new series of methylsulfonyl and sulfamoyl acetamides and ethyl acetates as potent COX-2 inhibitors

2015 ◽  
Vol 23 (4) ◽  
pp. 810-820 ◽  
Author(s):  
Sara Consalvi ◽  
Salvatore Alfonso ◽  
Angela Di Capua ◽  
Giovanna Poce ◽  
Adele Pirolli ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Docking Analysis ◽  
Cox 2 ◽  
Cox 2 Inhibitors

Design, synthesis, biological evaluation and molecular modeling of dihydropyrazole sulfonamide derivatives as potential COX-1/COX-2 inhibitors

2015 ◽  
Vol 25 (9) ◽  
pp. 1947-1951 ◽  
Author(s):  
Zhong Chen ◽  
Zhong-Chang Wang ◽  
Xiao-Qiang Yan ◽  
Peng-Fei Wang ◽  
Xiao-Yuan Lu ◽  
...  
Keyword(s):  
Molecular Modeling ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
Cox 1

scholarly journals Design, synthesis and biological evaluation of new 2-aminothiazole scaffolds as phosphodiesterase type 5 regulators and COX-1/COX-2 inhibitors

RSC Advances ◽  
2020 ◽  
Vol 10 (50) ◽  
pp. 29723-29736 ◽  
Author(s):  
Abdel Haleem M. Hussein ◽  
Ahmed A. Khames ◽  
Abu-Bakr A. El-Adasy ◽  
Ahmed A. Atalla ◽  
Mohamed Abdel-Rady ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Cox 2 ◽  
Phosphodiesterase Type ◽  
Cox 2 Inhibitors ◽  
Synthesis And Biological Evaluation ◽  
Cox 1

A new series of 2-aminothiazole derivatives was designed and prepared as phosphodiesterase type 5 (PDE5) regulators and COX-1/COX-2 inhibitors.

Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides

2008 ◽  
Vol 16 (5) ◽  
pp. 2697-2706 ◽  
Author(s):  
Shwu-Jiuan Lin ◽  
Wei-Jern Tsai ◽  
Wen-Fei Chiou ◽  
Tsang-Hsiung Yang ◽  
Li-Ming Yang
Keyword(s):  
Biological Evaluation ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
Synthesis And Biological Evaluation

Cyclooxygenase-2 plays a significant role in regulating the tone of the fetal lamb ductus arteriosus

1999 ◽  
Vol 276 (3) ◽  
pp. R913-R921 ◽  
Author(s):  
Ronald I. Clyman ◽  
Pierre Hardy ◽  
Nahid Waleh ◽  
Yao Qi Chen ◽  
Françoise Mauray ◽  
...  
Keyword(s):  
Significant Role ◽  
Ductus Arteriosus ◽  
Late Gestation ◽  
Relative Contribution ◽  
Cox Inhibitor ◽  
Fetal Lamb ◽  
Cox 2 ◽  
Cox 2 Inhibitors ◽  
Cox 1

Nonselective cyclooxygenase (COX) inhibitors are potent tocolytic agents but have adverse effects on the fetal ductus arteriosus. We hypothesized that COX-2 inhibitors may not affect the ductus if the predominant COX isoform is COX-1. To examine this hypothesis, we used ductus arteriosus obtained from late-gestation fetal lambs. In contrast to our hypothesis, fetal lamb ductus arteriosus expressed both COX-1- and COX-2-immunoreactive protein (by Western analysis). Although COX-1 was found in both endothelial and smooth muscle cells, COX-2 was found only in the endothelial cells lining the ductus lumen (by immunohistochemistry). The relative contribution of COX-1 and COX-2 to PGE2 synthesis was consistent with the immunohistochemical results: in the intact ductus, PGE2 formation was catalyzed by both COX-1 and COX-2 in equivalent proportions; in the endothelium-denuded ductus, COX-2 no longer played a significant role in PGE2 synthesis. NS-398, a selective inhibitor of COX-2, was 66% as effective as the selective COX-1 inhibitor valeryl salicylate and the nonselective COX inhibitor indomethacin in causing contraction of the ductus in vitro. At this time, caution should be used when recommending COX-2 inhibitors for use in pregnant women.

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