scholarly journals The development of atherosclerotic cardiovascular disease in inflammatory bowel disease

2021 ◽  
Vol 17 (4) ◽  
pp. 241-249
Author(s):  
Petronela Nicoleta Seritean Isac ◽  
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Inflammatory Bowel

scholarly journals Inflammatory Bowel Disease and Atherosclerotic Cardiovascular Disease

2020 ◽  
Vol 76 (24) ◽  
pp. 2895-2905
Author(s):  
Miguel Cainzos-Achirica ◽  
Kerri Glassner ◽  
Hassan Syed Zawahir ◽  
Amit K. Dey ◽  
Tanushree Agrawal ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Inflammatory Bowel

scholarly journals Atherosclerotic cardiovascular disease in inflammatory bowel disease: The role of chronic inflammation

2020 ◽  
Vol 11 (5) ◽  
pp. 104-113
Author(s):  
Simcha Weissman ◽  
Preetika Sinh ◽  
Tej I Mehta ◽  
Rishi K Thaker ◽  
Abraham Derman ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Chronic Inflammation ◽  
Bowel Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Inflammatory Bowel

Abstract 16424: Cardiovascular Risk Factors Among a Nationally Representative Adult Population With Inflammatory Bowel Disease and Without Clinical Atherosclerotic Cardiovascular Disease

Circulation ◽  
2020 ◽  
Vol 142 (Suppl_3) ◽  
Author(s):  
Tanushree Agrawal ◽  
Isaac Acquah ◽  
Amit Dey ◽  
Syed Z Hassan ◽  
Kerri Glassner ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Cardiovascular Risk ◽  
Bowel Disease ◽  
Adult Population ◽  
Chronic Inflammatory Disease ◽  
Atherosclerotic Cardiovascular Disease ◽  
Systemic Involvement ◽  
Inflammatory Bowel ◽  
Nationally Representative

Introduction: Inflammatory Bowel Disease (IBD), comprised of Ulcerative Colitis (UC) and Crohn’s Disease (CD) is a chronic inflammatory disease with systemic involvement. Inflammation predisposes to atherosclerosis and studies suggest that IBD is associated with premature atherosclerotic cardiovascular disease (ASCVD). There is, however, limited population-based data on cardiovascular risk factor (CRF) burden in IBD among those who have not yet developed clinical ASCVD. We sought to study the association between IBD and CRFs among a nationally representative population with IBD and without established ASCVD. Methods: The study population was derived from the 2015-2016 National Health Interview Survey database. ASCVD was defined as myocardial infarction, angina or stroke; those with ASCVD were excluded. IBD was defined as either CD or UC. We computed weighted prevalence estimates of various traditional CRFs for the US population by IBD status. Univariate and multivariate logistic regression models were used to evaluate associations between CRFs and IBD. Average and poor cardiovascular risk profiles were defined as 2-3 and ≥4 CRFs, respectively. Results: Overall 786 (1.2%) representing 2.6 million ASCVD-free adults reported IBD. Individuals with IBD had higher prevalence of multiple CRFs (Figure, top). In adjusted models those with IBD had significantly higher odds of having prevalent hypertension, diabetes mellitus and hypercholesterolemia (Figure, bottom). These associations were similar among elderly and young participants. Those with IBD were almost 2-fold more likely to have a poor cardiovascular risk profile. Conclusion: Our findings from a nationally representative US population suggest an increased burden and clustering of CRFs among IBD patients without clinical ASCVD. Future efforts are needed to understand the underlying mechanisms, and enhance the detection and treatment of these CRFs to reduce ASCVD risk in IBD patients.

Overview of Link Between Inflammatory Bowel Disease and Cardiovascular Disease

2018 ◽  
Vol 26 (6) ◽  
pp. 287-293 ◽  
Author(s):  
Matthew G. Nevulis ◽  
Colby Baker ◽  
Edward Lebovics ◽  
William H. Frishman
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Risk of cardiovascular disease in inflammatory bowel disease

2016 ◽  
Vol 13 (2) ◽  
pp. 395-400 ◽  
Author(s):  
Ping Wu ◽  
Fangyuan Jia ◽  
Bao Zhang ◽  
Peiying Zhang
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Bowel

scholarly journals Cardiovascular risks in patients with inflammatory bowel disease: what should be taken into account?

2021 ◽  
Vol 1 (6) ◽  
pp. 112-120
Author(s):  
G. B. Bikbavova ◽  
M. A. Livzan
Keyword(s):  
Cardiovascular Disease ◽  
Inflammatory Bowel Disease ◽  
Bowel Disease ◽  
Inflammatory Diseases ◽  
Treat To Target ◽  
Steady Increase ◽  
Cardiovascular Risks ◽  
Specialized Care ◽  
Pathogenetic Therapy ◽  
Inflammatory Bowel

In recent years, there has been a steady increase in the incidence of inflammatory bowel disease (IBD) worldwide. Treatment of ulcerative colitis and Crohn’s disease has become more effective thanks to the emergence of biological therapies, increased access to specialized care and a “treat to target” approach. However, with an increase in the life expectancy of patients with IBD, there is an increase in the number of persons with comorbidity, primarily with a combination of IBD with cardiovascular pathology. Environmental factors lead to a change in the diversity and density of colonization of the intestinal microbiota, a violation of its barrier function, immune dysregulation, which in turn leads to the development of chronic inflammatory diseases and atherosclerosis. Levels of proinflammatory cytokines, C-reactive protein, and homocysteine increase in IBD, leading to endothelial dysfunction and atherosclerosis. In addition, inflammatory processes in IBD promote hypercoagulation, which occurs both in the thromboembolic complications and in the pathogenesis of the disease itself. It has been suggested that medical pathogenetic therapy for IBD is also associated with the risk of cardiovascular disease. In this review, we systematize the available data on the risks of cardiovascular diseases in patients with IBD. A literature search containing information on relevant studies was carried out in PubMed and Google Scholar systems with the keywords: inflammatory bowel disease, cardiovascular disease, inflammation, atherosclerosis.

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