scholarly journals High HIV-1 prevalence, risk behaviours, and willingness to participate in HIV vaccine trials in fishing communities on Lake Victoria, Uganda

2013 ◽  
Vol 16 (1) ◽  
pp. 18621 ◽  
Author(s):  
Noah Kiwanuka ◽  
Ali Ssetaala ◽  
Juliet Mpendo ◽  
Matthias Wambuzi ◽  
Annet Nanvubya ◽  
...  
2006 ◽  
Vol 17 (3) ◽  
pp. 176-179 ◽  
Author(s):  
J Smit ◽  
K Middelkoop ◽  
L Myer ◽  
S Seedat ◽  
L-G Bekker ◽  
...  

Research on willingness to participate in HIV vaccine trials is important in preparations for HIV vaccine research, but there are few data from sub-Saharan Africa. We interviewed 198 individuals in a peri-urban South African community immediately after enrolment into an HIV vaccine preparedness study on their willingness to participate in hypothetical vaccine trials. Overall 23% of participants ( n = 46) said that they would be willing to participate in an HIV vaccine trial. Willingness was associated with increasing age, male gender, and increasing knowledge about vaccines generally and HIV vaccines specifically. In multivariate analysis, a 1-unit increase in HIV vaccine knowledge score was associated with a 10-fold increase in willingness to participate (adjusted odds ratio, 10.72, 95% confidence intervals: 4.40–26.12). These results suggest that while willingness to participate in HIV vaccine trials is relatively low in this setting, educational campaigns may have a substantial impact on individuals' willingness to participate in research.


Vaccine ◽  
2013 ◽  
Vol 31 (44) ◽  
pp. 5055-5061 ◽  
Author(s):  
Gershim Asiki ◽  
Andrew Abaasa ◽  
Eugene Ruzagira ◽  
Freddie Kibengo ◽  
Ubaldo Bahemuka ◽  
...  

2005 ◽  
Vol 16 (4) ◽  
pp. 314-317 ◽  
Author(s):  
Paul Van de Ven ◽  
Limin Mao ◽  
June Crawford ◽  
Garrett Prestage ◽  
Andrew Grulich ◽  
...  

This study aimed to determine and describe HIV-negative gay men's willingness to participate in HIV vaccine trials. Data were from participants who completed face-to-face interviews during the first 18 months (to the end of 2002) of recruitment into the Health in Men cohort of HIV-negative gay men in Sydney. A key outcome measure was a scale of Willingness to Participate in HIV Vaccine Trials, with scores ranging from 1 (unwilling) to 4 (willing). The 903 participants ranged in age from 18 to 75years (median=36). Mean of Willingness to Participate in HIV Vaccine Trials was 2.53 (standard deviation=0.54), with approximately 51% of the men having a score greater than the midpoint of 2.50. A reduced linear regression model yielded four significant independent associations with Willingness to Participate in HIV Vaccine Trials: lack of tertiary education ( P <0.001),having engaged 'in the previous six months' in any unprotected anal intercourse with casual or non-concordant regular partners ( P <0.001), higher self-rated likelihood of HIV infection ( P <0.01), and higher mean scores on a scale of Comfort with Participation in HIV VaccineTrials ( P <0.001). The willingness of HIV-negative gay men at potentially higher risk for HIV to participate in HIV vaccine trials augurs well for enrolment in HIV vaccine efficacy trials. Recruitment into trials is likely to be enhanced by addressing salient concerns such as confidentiality and vaccine-induced antibody positivity. Also, it will be important to ensure that gay men are educated and fully informed about HIV vaccines and trial processes.


2012 ◽  
Vol 17 (2) ◽  
pp. 760-772 ◽  
Author(s):  
Barbara Metch ◽  
Ian Frank ◽  
Richard Novak ◽  
Edith Swann ◽  
David Metzger ◽  
...  

2000 ◽  
Vol 25 (5) ◽  
pp. 459-463 ◽  
Author(s):  
André R.S. Périssé ◽  
Mauro Schechter ◽  
Ronaldo I. Moreira ◽  
Regina F. do Lago ◽  
Guilherme Santoro-Lopes ◽  
...  

Vaccine ◽  
2014 ◽  
Vol 32 (44) ◽  
pp. 5854-5861 ◽  
Author(s):  
Peter A. Newman ◽  
Venkatesan Chakrapani ◽  
James Weaver ◽  
Murali Shunmugam ◽  
Clara Rubincam

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